Protein Alignment kis and XNP

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Alignment Length: 1659
• Identity: 354/1659 - (21%)
• Similarity: 595/1659 - (35%)
• Gaps: 596/1659 - (35%)

  Fly  1380 PKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDS------- 1437
            |.|...|.....|:            ||...|.:.|  .|...|:::..|:..|.|.|
  Fly     6 PNARHTDAATPLTT------------DDSNSSSVSR--RESATESKSASESESSPPRSNTKQSRT 56

  Fly  1438 -----AGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNR-----GSLSAKALKKRRNRGRIVP 1492
                 |...|:..|..|..::.|.|  :||.||.....|.|     ..|::...|:|.:||
  Fly    57 HKNVKASGKATVSSSSDSDQAVANS--SANDEEKEPVCKIRIVPLEKLLASPKTKERPSRG---- 115

  Fly  1493 ESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFS----DDENSLLVASPVK 1553
             |..::.|::.:....|...|::....|:|     |.|....:.|..|    ::|.|||||.|:.
  Fly   116 -SQQKNVTINDSSDEEPLKGSKLVLPARKS-----RNKNASIIELSDSEEVDEEEESLLVAIPLP 174

  Fly  1554 KD---KKPSANASNSNAGSDVEKTEPQSGAEGDAAQEV----GEEKSNLPLDESSQLEASSSTSA 1611
            |:   .||..|:|.::..|..::.:.|..|...:|:.:    |..:.:|..:.||:..:|.:.|.
  Fly   175 KEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESP 239

  Fly  1612 VAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEK-APEPKQD 1675
            ...|.                            .||:|       ||   :..||.| |.:||:.
  Fly   240 PRPKR----------------------------CVVRL-------KR---VSLPKTKPAQKPKKM 266

  Fly  1676 EEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKD 1740
            ...|| :.|||.|.....:.|:|.|:..|             .|..:.||.|.::.|.|.::
  Fly   267 SSDSE-EAATTSKKSRQRRSKSESEADSD-------------YEAPAAEEEEEEERKSSGDE--- 314

  Fly  1741 KDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKA 1805
                  ::....||.|..|:.:....|:|
  Fly   315 ------EEAANSSDSEVMPQRKRRRKKSE------------------------------------ 337

  Fly  1806 NDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEAD--- 1867
                         .:|.:.|..||    ||.|            |:|.:.:||.:..:::.|
  Fly   338 -------------SDKGSSDFEPE----EKQK------------KKGRKRIKKTSSGESDGDGDD 373

  Fly  1868 --MENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENI 1930
              .:||.:.:     ...:|.::......|...||:    |||     :|.:.:|.....||...
  Fly   374 DKQKNKRKHI-----RKIIKTKDLDLTTKEAAKEED----DRR-----KRIEDRQKLYNRIFVKS 424

  Fly  1931 EDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFN 1995
            |....|                                         ||..|.|.:..:..|:.:
  Fly   425 ESVEIN-----------------------------------------ELVLDFDEESKKALLQVD 448

  Fly  1996 KIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSW---YNT---------H 2048
            |               .|.||            |:|:|:.|   :||.|   :.|         .
  Fly   449 K---------------GLLKK------------LKPHQVAG---VKFMWDACFETLKESQEKPGS 483

  Fly  2049 NCILADEMGLGKTIQSLTFVHSVY----EYGIRGPFLVIAPLSTIPNWQREFEGWTDMNVVVYHG 2109
            .||||..||||||:|.:|..|::.    ..|: ...|:|:||||:.||.|||..|.
  Fly   484 GCILAHCMGLGKTLQVVTLSHTLLVNTRRTGV-DRVLIISPLSTVNNWAREFTSWM--------- 538

  Fly  2110 SVTSKQMIQDYEY-YYKTESGKVLKEPIKFN---VLITTFEMIVTDYMDL---KAFNWR------ 2161
            ...::..|:.|:. .||.:..::.|....||   |.|..::|    |..|   ||...|
  Fly   539 KFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDM----YRILANEKAKGLRKKQREQ 599

  Fly  2162 -----------LCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPS 2215
                       |.|.||.|.|||....:.:.:.::..:.|::|:|||||||:.|.:.::.|::|:
  Fly   600 LMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPN 664

  Fly  2216 QFSSQEEFMSEF------GSL--RTEEEV-------NKLQALLKPMMLRRLKDDVEKSLAPKEET 2265
            ...:.:|:|:.|      |..  .||.::       :.|..||:..:.||....:...|.||.|.
  Fly   665 LLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEY 729

  Fly  2266 IIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPY------------- 2317
            ::...|:.:|:|.| |...........|........|.....:||:...||.
  Fly   730 VVYTTLSELQQKLY-GYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKR 793

  Fly  2318 LLNGAEEQIQ--------------------YDFKS-------------------QHG-------- 2335
            ||:..:..::                    ..|||                   ::|
  Fly   794 LLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSD 858

  Fly  2336 -----------------EDPESYYK--------NLILSAGKMVLIDKLLPKLKANGHRVLIFSQM 2375
                             :||..::|        |.:..:.|::::.:||.:.:|.|.::|:|||.
  Fly   859 SDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQS 923

  Fly  2376 VRCLDILEDYLVY-----RKYPFE-----------------RIDGRIRGNLRQEAIDRYSKPGSD 2418
            ::.||::|.:|..     :.|.||                 |:||......|:....:::...:.
  Fly   924 LQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNL 988

  Fly  2419 RF-VFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYER 2482
            |. :||:.|:||||||||.||:.|:|:|..|||.:|.|:..|.:|.||.|...||||:...|.|:
  Fly   989 RARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQ 1053

  Fly  2483 EMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIE-DLLKKGAYGAVMDDDNAGDKFCEED 2546
            :::::...|....|.|:           :.:|:|:...: ||::..:|.
  Fly  1054 KVYERQVAKQATAKRVI-----------DEQQISRHYNQTDLMELYSYE---------------- 1091

  Fly  2547 IDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETED 2611
                ||..|:                                      :::.|.|    :|....
  Fly  1092 ----LKPSTE--------------------------------------REMPILP----KDRLFA 1110

  Fly  2612 LVLSEPRRRTQIKRYGHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPR 2676
            .:|:| ..:...|.:.|:.::|  .||..|...:|.     :|...:.:.::.|..:.: :|:..
  Fly  1111 EILTE-HEKLIFKYHEHDSLLE--QEEHENLTEEER-----KSAWAEYEAEKTRTVQAS-QYMSY 1166

  Fly  2677 ERDALA--ALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFK--RGWRDVDVEDCAR 2737
            :|:|..  .:|    |:||.:.|    |....: ||: |...||:|...|  :..::::.....:
  Fly  1167 DRNAFGNQVMG----QFGNASGS----VTSNKI-FGF-RSDILLQLLNMKISKDHQELNQNQVIQ 1221

  Fly  2738 IILLYCLQVY----KGDEKIKTFIWDLITPTEDGEVQKISRDHSGLH-NLV-PRGR--------- 2787
            ::..|..|:|    .||            ||       :.:|...|| |:| |.|.
  Fly  1222 LVPTYLQQLYNEMNNGD------------PT-------MYKDLLNLHSNIVHPSGMYMNPLLYAN 1267

  Fly  2788 ---NGGKSNKESTGV-------------STPAPG 2805
               |....|:.:.||             :.||||
  Fly  1268 QNPNAAGYNQGTGGVPPMAGGSVAHGPPAAPAPG 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	32/136 (24%)
		PTZ00121	<1419..1923	CDD:173412	112/537 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/71 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	5/57 (9%)
		PLN03142	2029..>2606	CDD:215601	171/740 (23%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	87/494 (18%)
		HepA	<382..1071	CDD:440319	183/799 (23%)
		DEXHc_ATRX	455..699	CDD:350826	75/260 (29%)