Protein Alignment kis and Ino80

DIOPT Version :9

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0086613
• Length: 1638
• Species: Drosophila melanogaster
• Alignment Length: 1795
• Identity: 405/1795 - (22%)
• Similarity: 652/1795 - (36%)
• Gaps: 684/1795 - (38%)

  Fly  1475 SLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRF 1539
            :::.::|:|        |.|..|:            .|.|....:....:::.....:..|.::.
  Fly    36 NMAKRSLRK--------PLSSDEE------------TDDEHVVKREHDVQDSDDSSTVGVVRMKQ 80

  Fly  1540 SDDENSLLVASPVKKDKKPSANASNSNAG--------------SDVEKTEPQSGAEGDAAQEVGE 1590
            |....|.|:||   |:::.|..|...|..              ||.|..:| :..|.:..|::..
  Fly    81 SSKRKSRLLAS---KEERQSVKAQLYNFNDLTSDREWLYDLLLSDTESDDP-TITEDEYVQQLLR 141

  Fly  1591 EKSNLPLDESSQLEASSSTSAVAEKERQIST---DAANAAMSSKPNYVYINTG---DEDSMVV-Q 1648
            |.                    ..::||...   .||||      .|.|..:|   :.|.... |
  Fly   142 EH--------------------VREQRQRKNYYKKAANA------QYAYYGSGLLSNHDIFAERQ 180

  Fly  1649 LVLA-----MRMGKRELILDKPKE--KAPEPKQDEEKSELDEATTDKPEGDE-------KFKTEG 1699
            |..|     .|..|:|:::.:..|  ..|:|.:...:..........||..|       |: |.|
  Fly   181 LATAGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKY-TFG 244

  Fly  1700 ESKKDLTDSEET------KLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESK 1758
            ::..:..|.:|.      |.|.:::.:|..||.|.::              |||.|.|...:.:|
  Fly   245 DTLPNNEDDDEDGGEVDYKRELASLALDYPEEEEIEE--------------EVDVEGGTEGQVTK 295

  Fly  1759 PEEQSET-------------VKTEENSKAIEEDKSST---VLTADHAKEPETVLEKMEVDEKAND 1807
            ...:.:.             :.:::.|..::..||:.   :|.  :.|....:..|: |.::|.:
  Fly   296 VRRKRKNPAALAARRRRIWQIMSKKESGRLQRIKSNNHKEMLA--NCKRVAGMCAKV-VRQRAIN 357

  Fly  1808 DQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKP 1872
            .|..:.:.....::.|             :|.|......||| |.::..|:|.    ||:.:.|.
  Fly   358 SQRIMKETVWRAKRLT-------------REMLAYWKRYERV-ERDQRRKQER----EAEEQRKQ 404

  Fly  1873 EPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQ 1937
            :...|:|:.   :.|..::|    .|:.||..  ..::.|:.  |..:..||.|...:::|...:
  Fly   405 DVELIEVKR---QQRKLNFL----ITQTELYA--HFMSKKLG--QGSEEDQLRILSQLDEETNAR 458

  Fly  1938 DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSE 2002
                      ::...|..:||        .|.|..|:....::.|:  ||...:..|.|..::.|
  Fly   459 ----------LAAQDDYDAGE--------MKLLAQENAEAAMQRDL--DKTRAFDVFAKKKEKEE 503

  Fly  2003 WKS--------KKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLG 2059
            .:.        |..|.||: |.|.:..::||  :|:.||::|:.||...:....:.|||||||||
  Fly   504 EEQAQESVEDIKPEPRPEM-KDLPQPKMFKG--TLKGYQIKGMTWLANIYDQGISGILADEMGLG 565

  Fly  2060 KTIQSLTFV-HSVYEYGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQ---D 2119
            ||:||:.|: |....||:.||||||:|.||:.|||:|...:. |..||.|.||...:::::   |
  Fly   566 KTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWD 630

  Fly  2120 YEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLK---NRNCKLLEG 2181
            .::.:..::        .|:|:||:::::|:||.......|:..|:|||..:|   ::..|||.|
  Fly   631 QKHLHTRDA--------SFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLG 687

  Fly  2182 LRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF-------GSLRT---EEEV 2236
               .:..:|:||||||:||:::||::||:|:.|:.|.|.:||...|       ...:|   |:::
  Fly   688 ---FSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQI 749

  Fly  2237 NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILE----QNFSFLKKGTT-- 2295
            ::|..:|||.||||:|.|||..|:.|.|.::...||..||..||.:.:    ::...|..|:|
  Fly   750 SRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTT 814

  Fly  2296 --SANIPNLMNTMMELRKCCIHPYL---------------------------------------- 2318
              |::..||||.:|:.||.|.||.|
  Fly   815 SSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLL 879

  Fly  2319 -------------------------------------------LNG------------------- 2321
                                                       |||
  Fly   880 YNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLA 944

  Fly  2322 ---------------------------------------------AEEQIQYDF----------- 2330
                                                         |.|...|.|
  Fly   945 YRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQET 1009

  Fly  2331 --------------------------------------KSQHGED------------------PE 2339
                                                  ||....|                  |.
  Fly  1010 IEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPR 1074

  Fly  2340 SYY-------------------------------------------------------------- 2342
            .|.
  Fly  1075 KYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGG 1139

  Fly  2343 ---------KNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDG 2398
                     :.||..|||:.::|.||.:||||||||||:|||.:.:|:||:|:.:||:.:.|:||
  Fly  1140 WSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDG 1204

  Fly  2399 RIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRI 2463
            ..:.:.|::.:..: :..:|.|||||.|:|||||||||||||||.|||||||..|.||..|.||:
  Fly  1205 SSKISARRDMVADF-QTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRL 1268

  Fly  2464 GQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNK--QLSKKEIEDLLKK 2526
            ||.|.|.:|||:|:.|.|..:..:|.     :|:.:|.|...|   ||.|  .|..||:..||
  Fly  1269 GQTKQVTVYRLICKGTIEERILQRAR-----EKSEIQRMVISG---GNFKPDTLKPKEVVSLL-- 1323

  Fly  2527 GAYGAVMDDDNAGDKFCEE---DIDSILKRRTQVITMESEK------------GSTFSKASFAAS 2576
                  :||:....|:.:|   ...|.:...||     ||:            |:|.  |:.:|:
  Fly  1324 ------LDDEEIEMKYRQEAKLQSSSPIPAATQ-----SERKRRHPQKDVNMGGTTI--AATSAT 1375

  Fly  2577 GNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSN 2641
            .|..    ||....:..||::.:        |||                  ||.::
  Fly  1376 QNPD----DDVPSCSSAAKRIKL--------ETE------------------EDFID-------- 1402

  Fly  2642 ENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGL 2706
                    :|:.|.......|........:.|:|         |...:|.
  Fly  1403 --------VGITSSASSVGTDSNHPTLSQETYVP---------GATCVQQ--------------- 1435

  Fly  2707 LSFGWGRWSELLELGQFKRGWRDVDVEDCARII------LLYCLQVYKGDEKIKTFIWDL--ITP 2763
                                 .::|.|:.|.::      :|       |..:...|:.||  |:|
  Fly  1436 ---------------------TEIDSENEALVVDGDSPTML-------GQNESMNFLDDLSGISP 1472

  Fly  2764 TEDGEVQKISRDH-SGLHNLVPRG---RNGGKSN----KESTGVSTPA-PGSAS-GSNSGNTTPA 2818
            ..       .|.| .|.....|||   |.||..:    ...|..:||| |.:|| .:.:|....|
  Fly  1473 MR-------RRHHPRGTRRGRPRGSTRRGGGHGSIPRVLTPTQAATPAVPATASQAAAAGTGAAA 1530

  Fly  2819 HKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKY 2858
            ..||.|...:...||.||..          |.|   :|:|
  Fly  1531 GTSSPLPQQEVSGGGDNAGV----------PLH---EEEY 1557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	54/288 (19%)
		HepA	1676..2527	CDD:223627	293/1200 (24%)
		SDA1	<1693..>1854	CDD:283052	34/189 (18%)
		CHROMO	<1879..1919	CDD:237991	8/39 (21%)
		Chromo	1941..1996	CDD:278797	10/54 (19%)
		DEXDc	2048..2197	CDD:238005	59/156 (38%)
		Helicase_C	2350..2464	CDD:278689	63/113 (56%)
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	29/156 (19%)
		SNF2_N	538..840	CDD:278600	116/312 (37%)
		DEXDc	555..700	CDD:238005	59/155 (38%)
		Helicase_C	1156..1269	CDD:278689	63/113 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467115
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930