Protein Alignment kis and CG10445

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 1020
• Identity: 198/1020 - (19%)
• Similarity: 326/1020 - (31%)
• Gaps: 399/1020 - (39%)

  Fly  1824 DDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPV------------- 1875
            :.|:|.: |||.:|:|..|:         ::|.....|...|.:...:||||
  Fly     2 ESSSPSD-TTEIHKQSCSIQ---------DQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNE 56

  Fly  1876 ---FIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQ 1937
               |:...||..|......|                 ..||...:|:|.|            ..:
  Fly    57 SAIFVSASEYNEKKAQIDQL-----------------VQKILTMEQQQRQ------------LEE 92

  Fly  1938 DFTEVDRVLDMSVHTDETSG--ETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQ---------- 1990
            :.:|...:.|:.:|.::.:.  |....:|          .|..|.||....|||.
  Fly    93 NASETKELCDLKLHLEKLNARLEALGEFL----------DTLRLREDQQEIKIEDNSELVDHTEQ 147

  Fly  1991 ------YLRFNKIPQRSEWKSKK-------------------RPHPELWKKLEKTPVYKGGNSLR 2030
                  |...|:..|::...:.:                   :|.|.: ..|||.|.......|:
  Fly   148 PKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAI-DDLEKQPALLLVRLLK 211

  Fly  2031 PYQLEGLNWLKF-SWYNTHNCILADEMGLGKTIQSLTFV-------------------------- 2068
             :|...|.|::| ........||||:||||||:..:..:
  Fly   212 -HQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEF 275

  Fly  2069 HSVY------------------------------------------------------------- 2072
            :.||
  Fly   276 NRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQ 340

  Fly  2073 -------------------EYGIRGPF-----LVIAPLSTIPNWQREFEGWTDMN---VVVYHGS 2110
                               |:...|.:     ||:.|:|.:..|..|.......|   |:.:||.
  Fly   341 KDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGP 405

  Fly  2111 VTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDY------MDLKAFNWRLCVIDEAH 2169
            ...:..|:.:..|               :::||::.::|.:.      ..|.|..|...::||||
  Fly   406 NRHEIGIEAFRSY---------------DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAH 455

  Fly  2170 RLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEE 2234
            .::|........:.||.......|:|||:||...::|:||.|:....|...:::...........
  Fly   456 IIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESMLGH 520

  Fly  2235 EVNKLQALLKPMMLRRLKDDVEKS-----------------LAPKEETIIEVELTNIQKKYYRGI 2282
              .:|..::||:||||.|..::.|                 |:..|..:.:: |:.|.||.:...
  Fly   521 --RRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQI-LSAISKKIFTQF 582

  Fly  2283 LEQNFSFLKKGTTSANIPNLMNT----------------------------------------MM 2307
            |.|.    :||.:..|..:|..|                                        ::
  Fly   583 LLQR----EKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLL 643

  Fly  2308 ELRKCCIHPYLLNG--------------------AEEQIQYD----------------------- 2329
            .||:.|.||.|:.|                    .|.|::.|
  Fly   644 RLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDS 708

  Fly  2330 ------FKSQ--------------HGED---------------------PESYYKNLILSAGKM- 2352
                  ||.:              .|:|                     |::.....|..:.|:
  Fly   709 TRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLK 773

  Fly  2353 VLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNL---RQEAIDRYSK 2414
            ::||||...|.....::::.||.|..|.|:...|  :...:|.:|  ..|.|   .:|.:.|...
  Fly   774 MVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRL--QDLSWETLD--FNGQLTAKEREIVLRDFN 834

  Fly  2415 PGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNT 2479
            ..:::.|.||...|||:|:||..|:.::|.|..||||.:.|||.|.:|.||.|...|||.:|::|
  Fly   835 ANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDT 899

  Fly  2480 YEREMFDKASMKLGLDKAVLQSMNTQGSK---DGNNKQLSKKEIE 2521
            .|:.:......||.:.|.||.....:.:|   .|.|....||..|
  Fly   900 VEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLFE 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	24/114 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/82 (17%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	13/75 (17%)
		PLN03142	2029..>2606	CDD:215601	152/762 (20%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	162/843 (19%)
		DEAD-like_helicase_N	209..534	CDD:475120	60/342 (18%)