Protein Alignment kis and Mi-2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 2310
• Identity: 572/2310 - (24%)
• Similarity: 886/2310 - (38%)
• Gaps: 688/2310 - (29%)

  Fly  1401 ESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEE 1465
            |....|:.|.:::...|:...|..: .||..|..|:.        |||.:|   .:.|:....||
  Fly    15 EEAQEDNAPAAELSNDSDAPLKPNQ-NDEDDDYDPED--------SRRKKK---GKKRKTRKGEE 67

  Fly  1466 GGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKK 1530
            .|..:|          |:::|      ||:.:.|.:........|..|:. ..||:..:...::|
  Fly    68 KGRKKK----------KRKKN------ESEEDSDFVQHDEEVEYPSTSKR-GRKRKEEKQAAKEK 115

  Fly  1531 --------YIDDVM---------LRFSDDENSLLV--------ASPVKKDKKPSANASN-----S 1565
                    .::||.         :.:|::|...|.        ..|:.:.:.|...|..     :
  Fly   116 ESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVA 180

  Fly  1566 NAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSS 1630
            ....:..::.|....||.||...|           |..:|.|.|....|:.|     ::.::.:.
  Fly   181 AKWREFCESNPHIQQEGGAAGSGG-----------SAGQARSVTGDEPEEPR-----SSRSSRNE 229

  Fly  1631 KPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDE-- 1693
            ||:.:|                      |..:::.:|:..|.|:...|.........:|.|..
  Fly   230 KPDDIY----------------------EEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPT 272

  Fly  1694 -KFKTEGESKKDLTDSE---------------ETKLESSAMEVDSKE---ESEPDDSKKSDEDN- 1738
             |.|..|:.|:|.:|.|               |..|:.|....|.||   .|:.|:|..:.:|:
  Fly   273 LKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDG 337

  Fly  1739 ------KDKDKMEVDDEVGKSDKESK----PEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPE 1793
                  :.|.|.::.::..|.:|..|    ||.:....:.::..:..::. ...:|.....:...
  Fly   338 SGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQG-GEIILCDTCPRAYH 401

  Fly  1794 TVLEKMEVDEKANDDQSAV-SKAE-GSDEKSTDDSNPEEATTEKNKESL---------------- 1840
            .|..:.|:||......|.. .:|: |:.|:..||.:.|.....|:...|
  Fly   402 LVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLN 466

  Fly  1841 -------------------EIEGEKERVKEGEESVKKENDE--KTEADMENKPEPVFIDVEEYFV 1884
                               .:.|:.|::.....: ::.||:  .|....:|...    .|.|||:
  Fly   467 PPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWA-QRSNDDGPSTSKGSKNSNS----RVREYFI 526

  Fly  1885 KYRNFSYLHCEW---------------------------RTEEELLKGDRRVAAKIRRFQQKQSQ 1922
            |:.|.||.||||                           :.||.|.:.|.|. .:|:|.:.|...
  Fly   527 KWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRY-KRIQRHKDKVGM 590

  Fly  1923 QLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDK 1987
            :.|....:.:|.|.::..:.:.::...|....|:.:.:..|||||:.|||:..||| ||..|...
  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWE-EEGDDIQG 654

  Fly  1988 IEQYLRF---------NKIPQRSEWKSKK------------------------RPHPELWKKLEK 2019
            :.|.:.:         ::..|....||||                        :|..:|.||.|.
  Fly   655 LRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYED 719

  Fly  2020 TPVYKGGN--SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFL 2081
            .|.:..|.  .|.|||:||:|||::||....:.|||||||||||||::||::|:|:.| .|||||
  Fly   720 QPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFL 784

  Fly  2082 VIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPI--------K 2137
            |..||||:.||:||||.|. |...:.|.|...|:.:|::.|..:  |.|.:....:        |
  Fly   785 VAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSF--EEGAIRGSKVSRLRTTQYK 847

  Fly  2138 FNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNI 2202
            ||||:|::|:|..|...|.:.:|.:.|:|||||||:...|....|....:.:::||:|||||||:
  Fly   848 FNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNL 912

  Fly  2203 SELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETII 2267
            .|||.|||||...:|:..:.|..||..:..||:|.:|..:|.|.||||||.||.|::..|.|.|:
  Fly   913 EELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIV 977

  Fly  2268 EVELTNIQKKYYRGILEQNFSFL--KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQ--- 2327
            .|||:.:|||:|:.||.:|:..|  |.|..|.   :|:|.||:|:|||.||||...|.|:..
  Fly   978 RVELSAMQKKFYKFILTKNYEALNSKSGGGSC---SLINIMMDLKKCCNHPYLFPSAAEEATTAA 1039

  Fly  2328 ---YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYR 2389
               |:..|            |..:|||:||:.|:|.:|||..|||||||||.:.||||||:|...
  Fly  1040 GGLYEINS------------LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGE 1092

  Fly  2390 KYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDL 2454
            :|.:|||||.|.|.||||||||::.||:.:|||||.|:||||||||..|||||||||||||.||:
  Fly  1093 QYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI 1157

  Fly  2455 QAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKE 2519
            ||.:|.|||||...|.|||.:.||:.|..:...|..|:.|...|::.  ..|.|..|   .:|:|
  Fly  1158 QAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRP--GMGGKGAN---FTKQE 1217

  Fly  2520 IEDLLKKGAYGAVMDDD-----NAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGN- 2578
            ::|:|:.|......:||     :..||...|.:|...:...:..:..:|..|:|..||:|....
  Fly  1218 LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEE 1282

  Fly  2579 --------RSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED----- 2630
                    :.|....||.:|.|..:.       ......||:..|..:.:...|:..:.|
  Fly  1283 EEEETEIIKQDAENSDPAYWVKLLRH-------HYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVA 1340

  Fly  2631 -------------VMELNSEESS-------NENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIP 2675
                         ..|.|||.|:       :::.|::.|...:::||.|:||        |..:|
  Fly  1341 ADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRD--------DRPLP 1397

  Fly  2676 RERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIIL 2740
               ..||.:|      ||        :|  :|.|...:....|                  ..|:
  Fly  1398 ---PLLARVG------GN--------IE--VLGFNARQRKSFL------------------NAIM 1425

  Fly  2741 LYCLQVYKGDEKIKTFIWDLITPTEDG-EVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAP 2804
            .|.:                  |.:|. ..|.:.||..            |||.:
  Fly  1426 RYGM------------------PPQDAFNSQWLVRDLR------------GKSER---------- 1450

  Fly  2805 GSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYK 2869
                                          |..|..:...     .|..:....:|:.:.:|..:
  Fly  1451 ------------------------------NFKAYVSLFM-----RHLCEPGADNAETFADGVPR 1480

  Fly  2870 KHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKS 2934
            :.|.|  ..||.|:.::..|:.:| .:| :.|.....:.||.::|
  Fly  1481 EGLSR--QHVLTRIGVMSLIRKKV-QEF-EHINGYYSMPELILKP-------------------- 1521

  Fly  2935 LLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTT 2999
                     ||..|                .|...|:|....|          ..|..||...||
  Fly  1522 ---------CEPVR----------------SALKQDVAALEAP----------PTGGNVDKSATT 1551

  Fly  3000 TTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDK---TESENDATTVSESSYKSE-- 3059
            :...:.:|                  |:..|.:..:..|.||   :|.|.|.|:..:|..|.|
  Fly  1552 SNSVTPAT------------------SAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQE 1598

  Fly  3060 ----VLPG---------------KGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSC 3105
                ..||               |.||.:|..          |:|.| :||....|.:|......
  Fly  1599 AEEDKKPGDVKQENPVEEAAGDTKPSDAEVKT----------EVAKT-EPKEETKDPEVKEEPKT 1652

  Fly  3106 DPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEG- 3169
            :..:....:.......|.|...|..::.|..|..:.||.:..|..|..||.|...:|..|..:|
  Fly  1653 EEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGA 1717

  Fly  3170 -DKTESCTNNATTNIS----TTTTTTTITNTTTTT------------------------------ 3199
             |..|........||:    |...|..:.......
  Fly  1718 EDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQD 1782

  Fly  3200 ----------NNPSS----------------------------------KAANSNNTTD--H--- 3215
                      |.|..                                  :||..|...|  |
  Fly  1783 IQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAM 1847

  Fly  3216 ------------ANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRN 3268
                        |.|:.||   .:||:||:.|                  .|..|.:|:.
  Fly  1848 SLNARFAEVECLAESHQHL---SKESLAGNKP------------------ANAVLHKVLN----- 1886

  Fly  3269 YKKEELKLQQK---AKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDA--SG 3328
             :.|||....|   ::|.|.::..||::.....:.:|:..:|.:.:|:..:.....||..|  .|
  Fly  1887 -QLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQG 1950

  Fly  3329 RSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQV 3363
            .:|.|.  :.|.:.:.|......|..|..|.:..|
  Fly  1951 TTLPAF--TSGPAGNFANFRPQFSVPGQLSNNSGV 1983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	22/98 (22%)
		PTZ00121	<1419..1923	CDD:173412	118/631 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	23/95 (24%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	17/66 (26%)
		PLN03142	2029..>2606	CDD:215601	262/608 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	6/52 (12%)
		TNG2	<282..422	CDD:227367	27/140 (19%)
		PHD1_CHD_II	380..422	CDD:277006	6/42 (14%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/74 (24%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	17/54 (31%)
		PLN03142	720..>1234	CDD:215601	247/535 (46%)
		DUF1087	<1292..1334	CDD:461922	9/48 (19%)
		CHDII_SANT-like	1380..1517	CDD:461920	40/260 (15%)
		CHDCT2	1757..1902	CDD:462358	23/171 (13%)