DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kis and Mi-2

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster


Alignment Length:2310 Identity:572/2310 - (24%)
Similarity:886/2310 - (38%) Gaps:688/2310 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1401 ESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEE 1465
            |....|:.|.:::...|:...|..: .||..|..|:.        |||.:|   .:.|:....||
  Fly    15 EEAQEDNAPAAELSNDSDAPLKPNQ-NDEDDDYDPED--------SRRKKK---GKKRKTRKGEE 67

  Fly  1466 GGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKK 1530
            .|..:|          |:::|      ||:.:.|.:........|..|:. ..||:..:...::|
  Fly    68 KGRKKK----------KRKKN------ESEEDSDFVQHDEEVEYPSTSKR-GRKRKEEKQAAKEK 115

  Fly  1531 --------YIDDVM---------LRFSDDENSLLV--------ASPVKKDKKPSANASN-----S 1565
                    .::||.         :.:|::|...|.        ..|:.:.:.|...|..     :
  Fly   116 ESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVA 180

  Fly  1566 NAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSS 1630
            ....:..::.|....||.||...|           |..:|.|.|....|:.|     ::.::.:.
  Fly   181 AKWREFCESNPHIQQEGGAAGSGG-----------SAGQARSVTGDEPEEPR-----SSRSSRNE 229

  Fly  1631 KPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDE-- 1693
            ||:.:|                      |..:::.:|:..|.|:...|.........:|.|..  
  Fly   230 KPDDIY----------------------EEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPT 272

  Fly  1694 -KFKTEGESKKDLTDSE---------------ETKLESSAMEVDSKE---ESEPDDSKKSDEDN- 1738
             |.|..|:.|:|.:|.|               |..|:.|....|.||   .|:.|:|..:.:|: 
  Fly   273 LKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDG 337

  Fly  1739 ------KDKDKMEVDDEVGKSDKESK----PEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPE 1793
                  :.|.|.::.::..|.:|..|    ||.:....:.::..:..::. ...:|.....:...
  Fly   338 SGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQG-GEIILCDTCPRAYH 401

  Fly  1794 TVLEKMEVDEKANDDQSAV-SKAE-GSDEKSTDDSNPEEATTEKNKESL---------------- 1840
            .|..:.|:||......|.. .:|: |:.|:..||.:.|.....|:...|                
  Fly   402 LVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLN 466

  Fly  1841 -------------------EIEGEKERVKEGEESVKKENDE--KTEADMENKPEPVFIDVEEYFV 1884
                               .:.|:.|::.....: ::.||:  .|....:|...    .|.|||:
  Fly   467 PPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWA-QRSNDDGPSTSKGSKNSNS----RVREYFI 526

  Fly  1885 KYRNFSYLHCEW---------------------------RTEEELLKGDRRVAAKIRRFQQKQSQ 1922
            |:.|.||.||||                           :.||.|.:.|.|. .:|:|.:.|...
  Fly   527 KWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRY-KRIQRHKDKVGM 590

  Fly  1923 QLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDK 1987
            :.|....:.:|.|.::..:.:.::...|....|:.:.:..|||||:.|||:..||| ||..|...
  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWE-EEGDDIQG 654

  Fly  1988 IEQYLRF---------NKIPQRSEWKSKK------------------------RPHPELWKKLEK 2019
            :.|.:.:         ::..|....||||                        :|..:|.||.|.
  Fly   655 LRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYED 719

  Fly  2020 TPVYKGGN--SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFL 2081
            .|.:..|.  .|.|||:||:|||::||....:.|||||||||||||::||::|:|:.| .|||||
  Fly   720 QPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFL 784

  Fly  2082 VIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPI--------K 2137
            |..||||:.||:||||.|. |...:.|.|...|:.:|::.|..:  |.|.:....:        |
  Fly   785 VAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSF--EEGAIRGSKVSRLRTTQYK 847

  Fly  2138 FNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNI 2202
            ||||:|::|:|..|...|.:.:|.:.|:|||||||:...|....|....:.:::||:|||||||:
  Fly   848 FNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNL 912

  Fly  2203 SELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETII 2267
            .|||.|||||...:|:..:.|..||..:..||:|.:|..:|.|.||||||.||.|::..|.|.|:
  Fly   913 EELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIV 977

  Fly  2268 EVELTNIQKKYYRGILEQNFSFL--KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQ--- 2327
            .|||:.:|||:|:.||.:|:..|  |.|..|.   :|:|.||:|:|||.||||...|.|:..   
  Fly   978 RVELSAMQKKFYKFILTKNYEALNSKSGGGSC---SLINIMMDLKKCCNHPYLFPSAAEEATTAA 1039

  Fly  2328 ---YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYR 2389
               |:..|            |..:|||:||:.|:|.:|||..|||||||||.:.||||||:|...
  Fly  1040 GGLYEINS------------LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGE 1092

  Fly  2390 KYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDL 2454
            :|.:|||||.|.|.||||||||::.||:.:|||||.|:||||||||..|||||||||||||.||:
  Fly  1093 QYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI 1157

  Fly  2455 QAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKE 2519
            ||.:|.|||||...|.|||.:.||:.|..:...|..|:.|...|::.  ..|.|..|   .:|:|
  Fly  1158 QAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRP--GMGGKGAN---FTKQE 1217

  Fly  2520 IEDLLKKGAYGAVMDDD-----NAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGN- 2578
            ::|:|:.|......:||     :..||...|.:|...:...:..:..:|..|:|..||:|.... 
  Fly  1218 LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEE 1282

  Fly  2579 --------RSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED----- 2630
                    :.|....||.:|.|..:.       ......||:..|..:.:...|:..:.|     
  Fly  1283 EEEETEIIKQDAENSDPAYWVKLLRH-------HYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVA 1340

  Fly  2631 -------------VMELNSEESS-------NENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIP 2675
                         ..|.|||.|:       :::.|::.|...:::||.|:||        |..:|
  Fly  1341 ADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRD--------DRPLP 1397

  Fly  2676 RERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIIL 2740
               ..||.:|      ||        :|  :|.|...:....|                  ..|:
  Fly  1398 ---PLLARVG------GN--------IE--VLGFNARQRKSFL------------------NAIM 1425

  Fly  2741 LYCLQVYKGDEKIKTFIWDLITPTEDG-EVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAP 2804
            .|.:                  |.:|. ..|.:.||..            |||.:          
  Fly  1426 RYGM------------------PPQDAFNSQWLVRDLR------------GKSER---------- 1450

  Fly  2805 GSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYK 2869
                                          |..|..:...     .|..:....:|:.:.:|..:
  Fly  1451 ------------------------------NFKAYVSLFM-----RHLCEPGADNAETFADGVPR 1480

  Fly  2870 KHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKS 2934
            :.|.|  ..||.|:.::..|:.:| .:| :.|.....:.||.::|                    
  Fly  1481 EGLSR--QHVLTRIGVMSLIRKKV-QEF-EHINGYYSMPELILKP-------------------- 1521

  Fly  2935 LLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTT 2999
                     ||..|                .|...|:|....|          ..|..||...||
  Fly  1522 ---------CEPVR----------------SALKQDVAALEAP----------PTGGNVDKSATT 1551

  Fly  3000 TTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDK---TESENDATTVSESSYKSE-- 3059
            :...:.:|                  |:..|.:..:..|.||   :|.|.|.|:..:|..|.|  
  Fly  1552 SNSVTPAT------------------SAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQE 1598

  Fly  3060 ----VLPG---------------KGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSC 3105
                ..||               |.||.:|..          |:|.| :||....|.:|......
  Fly  1599 AEEDKKPGDVKQENPVEEAAGDTKPSDAEVKT----------EVAKT-EPKEETKDPEVKEEPKT 1652

  Fly  3106 DPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEG- 3169
            :..:....:.......|.|...|..::.|..|..:.||.:..|..|..||.|...:|..|..:| 
  Fly  1653 EEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGA 1717

  Fly  3170 -DKTESCTNNATTNIS----TTTTTTTITNTTTTT------------------------------ 3199
             |..|........||:    |...|..:.......                              
  Fly  1718 EDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQD 1782

  Fly  3200 ----------NNPSS----------------------------------KAANSNNTTD--H--- 3215
                      |.|..                                  :||..|...|  |   
  Fly  1783 IQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAM 1847

  Fly  3216 ------------ANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRN 3268
                        |.|:.||   .:||:||:.|                  .|..|.:|:.     
  Fly  1848 SLNARFAEVECLAESHQHL---SKESLAGNKP------------------ANAVLHKVLN----- 1886

  Fly  3269 YKKEELKLQQK---AKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDA--SG 3328
             :.|||....|   ::|.|.::..||::.....:.:|:..:|.:.:|:..:.....||..|  .|
  Fly  1887 -QLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQG 1950

  Fly  3329 RSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQV 3363
            .:|.|.  :.|.:.:.|......|..|..|.:..|
  Fly  1951 TTLPAF--TSGPAGNFANFRPQFSVPGQLSNNSGV 1983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 49/268 (18%)
HepA 1676..2527 CDD:223627 343/1001 (34%)
SDA1 <1693..>1854 CDD:283052 40/229 (17%)
CHROMO <1879..1919 CDD:237991 19/66 (29%)
Chromo 1941..1996 CDD:278797 17/63 (27%)
DEXDc 2048..2197 CDD:238005 67/158 (42%)
Helicase_C 2350..2464 CDD:278689 77/113 (68%)
RR_TM4-6 3728..>3877 CDD:283990
BRK 4569..4613 CDD:197800
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 6/51 (12%)
PHD1_CHD_II 380..422 CDD:277006 6/42 (14%)
PHD2_CHD_II 440..482 CDD:277007 2/41 (5%)
CHROMO 490..558 CDD:237991 17/72 (24%)
CHROMO 615..667 CDD:214605 17/52 (33%)
SNF2_N 734..1028 CDD:278600 137/298 (46%)
DEXDc 751..907 CDD:238005 67/157 (43%)
Helicase_C 1053..1167 CDD:278689 77/113 (68%)
DUF1087 <1292..1337 CDD:283996 10/51 (20%)
DUF1086 1380..1517 CDD:283992 40/260 (15%)
CHDCT2 1756..1927 CDD:285336 28/197 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467116
Domainoid 1 1.000 152 1.000 Domainoid score I1379
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D54215at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45623
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.950

Return to query results.
Submit another query.