DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kis and brm

DIOPT Version :9

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1995	Identity:	477/1995 - (23%)
Similarity:	733/1995 - (36%)	Gaps:	622/1995 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1034 EEPKTVEESGEDKSQSAP--GVAPPADPII---------PVTQPPQQQMPP------------IG 1075
            :.|.....|.....|..|  |..||..|..         |...||...|||            :|
  Fly    25 QSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGPPGQGPPGHHMPPHHQGMIFSKGPHMG 89

  Fly  1076 MPMHPIAPGYEA-QAQGQGHMPPMMPPY------GGAPGMYPPYPMLHQQEIAALQQQI------ 1127
            |.|.|..|.... |..|   |||..|..      ||.||..||.....|:.:.|||:.|
  Fly    90 MQMPPTGPNMSPYQTHG---MPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEK 151

  Fly  1128 --------QELYCMPPGHELQH----QDKLMRMQ-ERLNLLTQHE-VNDQCAGGPQCLLFQNVP- 1177
                    .:|..|....:.||    |..|:|.| ....||.::: ::.|.....|....|..|
  Fly   152 GLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPG 216

  Fly  1178 PMYGPPG--------------NPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQ 1228
            |..||||              .|:..||..:.|..:.|..:.....|:.|..|.. .|:|.||..
  Fly   217 PPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPV-PGQKMQVAP 280

  Fly  1229 QQDLMDISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANE 1293
            ....|.
  Fly   281 PPPHMQ----------------------------------------------------------- 286

  Fly  1294 LDTSTDGSGKKKKPRKPRT----PKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKR 1354
                   .|:...|:.|:.    |....:||:.:..:::.|  |.:|:..:.|...|..:
  Fly   287 -------QGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPP--PPEPHQHQLPNGGKPLS----- 337

  Fly  1355 RKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNE 1419
               .|..|      |..:..:.|:.|:                |.|..|...  |.|::|:....
  Fly   338 ---MGPSG------GQPLIPSSPMQPQ----------------VRGTLPGMP--PGSQVPQPGGG 375

  Fly  1420 DEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKR 1484
            .:::          || .||.|...|:|..                  :..|..|......|::|
  Fly   376 PQRQ----------VP-PAGMPMPKPNRIT------------------TVAKPVGLDPITLLQER 411

  Fly  1485 RNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKR-------RSSR--NTQRKKYIDDVMLRFS 1540
            .|  ||..........|.|.|       :.|..:.|       |:.|  |.||:..::.|.....
  Fly   412 EN--RIAARISLRMQELQRLP-------ATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRR 467

  Fly  1541 DDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEA 1605
            |  .:|..|..:|..|                :|:.|...|..|.::         |::..:|||
  Fly   468 D--TTLETALNIKLYK----------------RTKRQGLREARATEK---------LEKQQKLEA 505

  Fly  1606 SSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGK--RELILDKPKEK 1668
            .       .|.||...:.                         |...::.||  ||.
  Fly   506 E-------RKRRQKHLEF-------------------------LAAVLQHGKDLREF-------- 530

  Fly  1669 APEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKK 1733
                 ....|::|  |..:|...:.....|.|.||     |:.::|...|.....|:.|  ..:|
  Fly   531 -----HRNNKAQL--ARMNKAVMNHHANAEREQKK-----EQERIEKERMRRLMAEDEE--GYRK 581

  Fly  1734 SDEDNKDKD----KMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPE- 1793
            ..:..|||.    ..:.|:.:....:..|..:..:..|.||..|.:.:.|...:::.::....|
  Fly   582 LIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEG 646

  Fly  1794 TVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKK 1858
            :::..|.|        ..|.:..|  :|.|.|..|   ..:.....|.:....:.:.:.|:|...
  Fly   647 SIVADMRV--------HVVEQCTG--KKLTGDDAP---MLKHLHRWLNMHPGWDWIDDEEDSCGS 698

  Fly  1859 ENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQ 1923
            .:|.|.:  :|.:|...                   |..|::....|
  Fly   699 NDDHKPK--VEEQPTAT-------------------EDATDKAQATG------------------ 724

  Fly  1924 LNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKI 1988
                 |.||..        |.:....|..||...|...:|.:
  Fly   725 -----NDEDAK--------DLITKAKVEDDEYRTEEQTYYSI----------------------- 753

  Fly  1989 EQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILA 2053
                                .|....|.:|:..:...| :|:.||::||.||...:.|..|.|||
  Fly   754 --------------------AHTIHEKVVEQASIMVNG-TLKEYQIKGLEWLVSLYNNNLNGILA 797

  Fly  2054 DEMGLGKTIQSLTFV-HSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTD-MNVVVYHGSVTSKQM 2116
            ||||||||||:::.| :.:....:.||:|:|.||||:|||..|||.|.. :.||.|.||...:::
  Fly   798 DEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRL 862

  Fly  2117 IQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEG 2181
            :|:.            ....|||||:||:|.::.|...|....|:..:|||.||:||.:|||.:.
  Fly   863 LQNQ------------MRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQV 915

  Fly  2182 LRQLNL-EHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE 2235
            |....: .:|:||:||||||.:.||::|||||.||.|.|...|...|.:          |..||.
  Fly   916 LNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEET 980

  Fly  2236 ---VNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYY-----RGILEQNFSFLKK 2292
               :.:|..:|:|.:|||||.:||..|..|.|.||:.:::.:|:..|     :|:|..:.|  :|
  Fly   981 ILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGS--EK 1043

  Fly  2293 GT-TSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHG--EDPESYYKNLILSAGKMVL 2354
            |. .......||||:::|||.|.||::....||: ..|....||  ..|:.|     ..:||..|
  Fly  1044 GKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEK-YCDHTGGHGVVSGPDLY-----RVSGKFEL 1102

  Fly  2355 IDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDR 2419
            :|::||||||..||||:|.||.:|:.|:||||.:|::.:.|:||..:...|.|.:.:::..|||.
  Fly  1103 LDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDV 1167

  Fly  2420 FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREM 2484
            |||||.|:|||||:||..||||:|:||||||..|||||.|.||||||..|::.||:..|:.|..:
  Fly  1168 FVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERI 1232

  Fly  2485 FDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDS 2549
            ...|..||.:|:.|:|:........|:.:|   :.::.:|.:        |||..::..|...|.
  Fly  1233 LAAARYKLNMDEKVIQAGMFDQKSTGSERQ---QFLQTILHQ--------DDNEEEEENEVPDDE 1286

  Fly  2550 ILKRRTQVITMESEKGSTFSKASFAASGNRSDI------TIDD---PDFWTKWAKKVDIDPDACE 2605
            ::   ..:|....|:...|.:..........:|      .||:   ||:.||       |.|..|
  Fly  1287 MI---NMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTK-------DDDEVE 1341

  Fly  2606 R---DETEDLVLSEPRRRTQIKRY-----------GHEDVMELNSEESSNENSDEEGGIGLRSRR 2656
            |   ...||.:|....|:.:...|           ..:|..|.:.||..::           |:|
  Fly  1342 RFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDD-----------SKR 1395

  Fly  2657 RKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGW-GR------- 2713
            ::.||...:|:..:|..|.:.|        ........:|.:..|:...::.... ||
  Fly  1396 KRRKRKNRKEESDDDSLILKRR--------RRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFM 1452

  Fly  2714 ----------WSELLELGQFKRGWRDVD-------VEDC--------ARIILLYC--LQVYKGDE 2751
                      :.|:::        |.||       :|||        .:..:..|  .|:|..:.
  Fly  1453 KLPSRQRLPDYYEIIK--------RPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEA 1509

  Fly  2752 KI---------KTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSA 2807
            .:         |.|:         |..|:|:                         .:..|...|
  Fly  1510 SLIYLDSIALQKVFV---------GARQRIT-------------------------AAADAAAVA 1540

  Fly  2808 SGSNSGNTTPAHKSSALDGSDK--DSGGIN-------ASAVAAAV 2843
            :|.|:|.   ||.:...|.||.  |.||.:       |:..||||
  Fly  1541 AGDNTGE---AHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAV 1582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	41/237 (17%)
		HepA	1676..2527	CDD:223627	268/879 (30%)
		SDA1	<1693..>1854	CDD:283052	30/165 (18%)
		CHROMO	<1879..1919	CDD:237991	3/39 (8%)
		Chromo	1941..1996	CDD:278797	6/54 (11%)
		DEXDc	2048..2197	CDD:238005	62/151 (41%)
		Helicase_C	2350..2464	CDD:278689	64/113 (57%)
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
brm	NP_001261906.1	QLQ	172..202	CDD:214931	8/29 (28%)
		Drf_FH1	251..390	CDD:283903	36/250 (14%)
		HSA	501..573	CDD:214727	22/123 (18%)
		BRK	649..693	CDD:197800	9/56 (16%)
		PHA02934	687..>824	CDD:165245	45/232 (19%)
		SNF2_N	776..1071	CDD:278600	122/308 (40%)
		DEXDc	793..932	CDD:238005	62/150 (41%)
		Helicase_C	1097..1212	CDD:278689	64/114 (56%)
		SnAC	1304..1375	CDD:291293	16/77 (21%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/121 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467114
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840