Protein Alignment kis and ERCC6L2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_064592.3
• Gene: ERCC6L2 / 375748
• HGNCID: 26922
• Length: 1550
• Species: Homo sapiens
• Alignment Length: 2079
• Identity: 427/2079 - (20%)
• Similarity: 699/2079 - (33%)
• Gaps: 752/2079 - (36%)

  Fly  1954 ETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQ-------------------YLRF--NKI 1997
            ||||:...|        |.|.|   |....||.|:.:                   |..|  .||
Human    11 ETSGKDIWH--------PGERC---LAPSPDNGKLCEASIKSITVDENGKSFAVVLYADFQERKI 64

  Fly  1998 P------------------------QRSEWKSKKRPHPELWKKL----EKTPVYKGGNSLRPYQL 2034
            |                        ::..:.::|.|...:..||    :..| |.....||.||.
Human    65 PLKQLQEVKFVKDCPRNLIFDDEDLEKPYFPNRKFPSSSVAFKLSDNGDSIP-YTINRYLRDYQR 128

  Fly  2035 EGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVY--------------EYGIRG------- 2078
            ||..:|...:.:...|||.|:||||||:|.::|:.:|.              |:.:|.
Human   129 EGTRFLYGHYIHGGGCILGDDMGLGKTVQVISFLAAVLHKKGTREDIENNMPEFLLRSMKKEPLS 193

  Fly  2079 -----PFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKF 2138
                 .||::||||.:.||:.|.:.|....|.|.||:....::|:             :|:. |.
Human   194 STAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGNRKDNELIR-------------VKQR-KC 244

  Fly  2139 NVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNIS 2203
            .:.:||:|.:.....:|.:..|...::|||||:||...::.|.::.|....|:.|:||.||||:.
Human   245 EIALTTYETLRLCLDELNSLEWSAVIVDEAHRIKNPKARVTEVMKALKCNVRIGLTGTILQNNMK 309

  Fly  2204 ELFSLLNFLEPSQFSSQEEFMSEFGS--------LRTEEEV----NKLQALLKPM---MLRRLKD 2253
            ||:.::::..|....|...|..:|..        ..|:.|:    ..:|.|.|.|   .|||.|.
Human   310 ELWCVMDWAVPGLLGSGTYFKKQFSDPVEHGQRHTATKRELATGRKAMQRLAKKMSGWFLRRTKT 374

  Fly  2254 DVEKSLAPKEETIIEVELTNIQKKYYRGILE-QNFSFLKKGTTSANIPNLMNTMMELRKCCI--- 2314
            .::..|..||:.::...||:.||..|:.:|| ::.:.:.:.:.    |....:..:.|.||.
Human   375 LIKDQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVTLILQSSE----PCTCRSGQKRRNCCYKTN 435

  Fly  2315 ----------------------HPYLLNGAEEQIQY----------------DF--KSQHG---- 2335
                                  |..||..|....|.                ||  ||:..
Human   436 SHGETVKTLYLSYLTVLQKVANHVALLQAASTSKQQETLIKRICDQVFSRFPDFVQKSKDAAFET 500

  Fly  2336 -EDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGR 2399
             .||:        .:|||.::.:||...:.|..:||:||...:.||:|:.|.:.....:.|:||.
Human   501 LSDPK--------YSGKMKVLQQLLNHCRKNRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGS 557

  Fly  2400 IRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIG 2464
            .:...|.:.:..::.. .|..:.|:.|.|||||:|...|:.|:::|..|||.|||||..|.:|||
Human   558 TKSEERLKIVKEFNST-QDVNICLVSTMAGGLGLNFVGANVVVLFDPTWNPANDLQAIDRAYRIG 621

  Fly  2465 QRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMN-------TQGSKDGNNKQLSKKEIED 2522
            |.:.||:.||:...|.|..|:.:...|..|...|:.|.|       .||||:...:...   |.:
Human   622 QCRDVKVLRLISLGTVEEIMYLRQIYKQQLHCVVVGSENAKRYFEAVQGSKEHQGELFG---IHN 683

  Fly  2523 LLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDP 2587
            |.|..:.|:.:..|             ||:|..||     |.|...:
Human   684 LFKFRSQGSCLTKD-------------ILEREGQV-----EAGIMTA------------------ 712

  Fly  2588 DFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEES---SNENSDEE-- 2647
               |.|.|:   .|.|.:        |..||:....:..|.|...|..::|:   .::.||||
Human   713 ---TTWLKE---GPPAHK--------LEMPRQPDCQECRGTEQAAEPLAKEACDLCSDFSDEEPV 763

  Fly  2648 GGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWG 2712
            |..|:::.:.|               .|....|.::.|                 :..||..|
Human   764 GATGIKTAKNK---------------APDSSKASSSPG-----------------QLTLLQCG-- 794

  Fly  2713 RWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHS 2777
             :|:|||                               .|.|.        .||.:....|.|.|
Human   795 -FSKLLE-------------------------------TKCKA--------VEDSDGNTASDDES 819

  Fly  2778 GLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAA 2842
                          |:::.|.:||.|..:....|                 :||.|.
Human   820 --------------SDEQPTCLSTEAKDAGCEKN-----------------QDSLGT-------- 845

  Fly  2843 VTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPI 2907
                      ||.:|.|   .:....:||:...:.|:|                 .|.|...:
Human   846 ----------SKHQKLD---NILNPKEKHIFYKSEKIL-----------------EQNISSKS-- 878

  Fly  2908 SELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLA 2972
                                    |:..:..|.||              |.:.:|......|.:.
Human   879 ------------------------DEKKIKNTDKH--------------CILQNVTESEDSDVIC 905

  Fly  2973 VTS-----LPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSS 3032
            .|.     .|.|........:..::.:.:.|..|:::|:::.| .|.::.::       |.|.|.
Human   906 PTQYTTERFPDNSIRFKPPLEGSEDSETEHTVKTRNNDNSRNT-DDKRNGII-------SKKLSP 962

  Fly  3033 ENASGGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDA 3097
            ||              ||:      ..:|..||               |.::::.||
Human   963 EN--------------TTL------KSILKRKG---------------TSDISDESD-------- 984

  Fly  3098 QVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSA 3162
                                               |||...|...::...|.......|.||:
Human   985 -----------------------------------DIEISSKSRVRKRASSLRFKRIKETKKE-- 1012

  Fly  3163 AIARAEGDKTESCTNNATTNISTTTTTTTITNTTTTTN-NPSSKAANSNNTTDHANSNSHLGLDE 3226
                                :..:..|...||.....| :.:|:..:..:::|.:.|.||....:
Human  1013 --------------------LHNSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSK 1057

  Fly  3227 EESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKEELKLQQKAKLQALVSSTPP 3291
            :     |:.|  ..:.|.|:....:...|.:....|.........|::..|::
Human  1058 Q-----SHRP--RTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQ------------ 1103

  Fly  3292 LSVPTTPTLQSMQ-----MQLQSGSGSGGSGIGSS-AQHDASGRSLQALMQSQGASTSAAAAAAA 3350
                   :.:||.     :|..:...|..:.|||| |::..|..:...:.:.:..|...|..|.
Human  1104 -------SYESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAV- 1160

  Fly  3351 SSAGGSCSGSGQVGMGGAGVMP-----AMPTAADISLMLSILNTTDVNQLANLDINKLAMYLVSM 3410
                  ||.........|..:|     ..|:...|||.|.|.|  .|||      .|..:|
Human  1161 ------CSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLYISN--PVNQ------KKKKVY---- 1207

  Fly  3411 NNKMERQGKMELAAKERESQRLQLIPK--KWNRREEYEFLRVLTGYGVDLHVSTPMASSNGSSLS 3473
                            ..:|...:|.:  |..||:::|                .|||...||..
Human  1208 ----------------HTNQTTFIIGETPKGIRRKQFE----------------EMASYFNSSSV 1240

  Fly  3474 PDWTKFKQMAHLERKSDETLTDYY-------KVFVAMCKRQAGLKLSESERGLEGIIEEIEKEHA 3531
            .::.|....|..|.: .:.|.|:|       |.|......|  ...|..|:|         ::..
Human  1241 NEFAKHITNATSEER-QKMLRDFYASQYPEVKEFFVDSVSQ--FNNSSFEKG---------EQRT 1293

  Fly  3532 KLILDRLEVLAKLREVARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLK----------- 3585
            :...|:.|.|.|       |.|.:...|..|::.          :|......||
Human  1294 RKKSDKRESLIK-------PRLSDSETLSFKDST----------NKISQVCSLKTYKRKSVKFQN 1341

  Fly  3586 HGLYRSETFIFNDPNFSFGESEKRFIRELEAQIQRTIKLEAFNAEKAEKLAAAEKDAATEKAAAT 3650
            |..||.|.| |||     .|::|       :.:..|.:::      :.|.:.|.:|..|.::..:
Human  1342 HISYREEVF-FND-----AETKK-------SPVSSTQEID------SGKNSQASEDTVTSRSLNS 1387

  Fly  3651 EKAAAEKAASVKNEVIDLDDELMTNESVIKKESPVTPIKEEIKSEESPEKHDTA----------- 3704
            |....|:  .::|.:.|..|  :|...:.:|| |:  :|.|.|..|:|...:|:
Human  1388 ESETRER--RLENTMKDQQD--LTRTGISRKE-PL--LKLENKKIENPVLENTSVISLLGDTSIL 1445

  Fly  3705 DNL--EDKNSDAEESTKI------KGKE---DFNPETTEKEALDESTNLNKDKSSTETLVPEIED 3758
            |:|  ...||..:...|:      |.|:   ||.....|:.  |||.:...|.:..|||
Human  1446 DDLFKSHGNSPTQLPKKVLSGPMEKAKQRPKDFWDILNEQN--DESLSKLTDLAVIETL------ 1502

  Fly  3759 SKPSEDKMEVEELPVAENGEKEGSPEKCSDAEDKKFSEEKPSSPAVPDGKVSEMEADEAAPNTE 3822
                     .|:.|:|...::...|.......::||..:          |.|..:.||.|.||:
Human  1503 ---------CEKAPLAAPFKRREEPATSLWKSNEKFLWK----------KFSPSDTDENATNTQ 1547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	14/61 (23%)
		PLN03142	2029..>2606	CDD:215601	178/673 (26%)
		PTZ00341	<3662..3887	CDD:173534	43/183 (23%)
		BRK	4568..4611	CDD:462196
ERCC6L2	NP_064592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/19 (32%)
		Tudor_ERCC6L2	18..73	CDD:410471	13/65 (20%)
		HepA	<107..651	CDD:440319	157/571 (27%)
		DEXHc_ERCC6L2	123..371	CDD:350763	74/261 (28%)
		DEAH box	272..275		2/2 (100%)
		Atypical PIP-box. /evidence=ECO:0000269|PubMed:37014751	785..796		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..848		14/88 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..1002		25/173 (14%)
		VIGSSK	<1118..1142	CDD:464308	7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1354..1410		13/72 (18%)