Protein Alignment kis and Rad54l2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001127992.2
• Gene: Rad54l2 / 363135
• RGDID: 1561889
• Length: 1466
• Species: Rattus norvegicus
• Alignment Length: 1594
• Identity: 340/1594 - (21%)
• Similarity: 565/1594 - (35%)
• Gaps: 443/1594 - (27%)

  Fly  1734 SDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEK 1798
            |||.....|. ::|.:|...|.|.  ||:.|.|..||:.:..||.     |..|.:.|.....|.
  Rat     2 SDESASGSDP-DLDPDVELEDAEE--EEEEEEVAVEEHDRDDEEG-----LLDDPSLEGMCGTEH 58

  Fly  1799 MEVDEKANDDQ-------SAVSKAEGSDE-----KSTDDSNPEEATTEK------NKESLEIEGE 1845
            .::.|   |.|       :..|::|.|::     |.....:|::...:|      |...|..|.:
  Rat    59 AQLGE---DGQRPPRCTSTTSSQSEPSEQLRHQGKILASEDPKKKRAQKPSHMRRNIRKLLREDQ 120

  Fly  1846 KERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGD---- 1906
            .|.|.:..:..:.|..::.|...:....|:              ..:..|:..||.:|:..
  Rat   121 LEPVTKAAQQEELERRKRLEQQRKEYAAPI--------------PTVPLEFLPEEIVLRASDGPQ 171

  Fly  1907 --RRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSG-ETTKHYLVKWK 1968
              .||.|       ::...|:.....|||..::     |.|:::|      || |.|.|.:...:
  Rat   172 LPPRVLA-------QEVICLDSSSGSEDEKSSR-----DEVIELS------SGEEDTLHIVDSSE 218

  Fly  1969 SLPYEDCTWELEEDVD---NDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKG---GN 2027
            |:..||   |.||...   ||.:.|:....::.....       ||.     |:..|:..   ..
  Rat   219 SVSEED---EEEEKGGTHVNDALNQHDALGRVLVNLN-------HPP-----EEENVFLAPQLAR 268

  Fly  2028 SLRPYQLEGLNWL---------KFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVI 2083
            :::|:|:.|:.:|         :|...:...||||..||||||:|.::|:..::.:......|.|
  Rat   269 AVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAI 333

  Fly  2084 APLSTIPNWQREFEGW---------------------------TDMNVVVYHGSVTSK------Q 2115
            .|::|:.||..||..|                           .:...|.....||:.      .
  Rat   334 VPVNTLQNWLAEFNMWLPAPEALPADSKPEEIQPRFFKVHILNDEHKTVASRAKVTTDWVSEGGV 398

  Fly  2116 MIQDYEYY------YKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLC-------VIDE 2167
            ::..||.|      ....:|:..|...:.:.:|...:.........:.|...||       :.||
  Rat   399 LLMGYEMYRLLTLKKSLATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDE 463

  Fly  2168 AHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF----- 2227
            .||:||......:.|:.:....||:|:|.|||||:.|.:.:::|:.|....:::||.:.|
  Rat   464 GHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPIL 528

  Fly  2228 -GSL--RTEEEV-------NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGI 2282
             |..  .|.::|       :.|.:||:..:.||....::..|..|||.:|.|.|:.||:..|...
  Rat   529 NGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQF 593

  Fly  2283 LEQNFSFLKKGTTSANIPNLMNTMMELRKCC---IHPYLL-------NGAEEQIQYDFKSQH--- 2334
            :::.......|...      :|.:.....||   .||.:|       |.|.||   |...:.
  Rat   594 MDRFRDCGSSGWLG------LNPLKAFCVCCKIWNHPDVLYEALQKENLANEQ---DLDVEELGS 649

  Fly  2335 ---------------GED---PES-------------------------------------YYKN 2344
                           |||   |.|                                     |...
  Rat   650 AGTSTRCPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTG 714

  Fly  2345 LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYP----------------- 2392
            ::.::.||||:..|:.:....|.::|:|||.:..|.::|::|..|..|
  Rat   715 VLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCPPGAEGQGAQKWVRNV 779

  Fly  2393 -FERIDGRIRGNLRQEAIDRYSKPGS-DRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQ 2455
             :.|:||......|:..|::::.|.: ..::|||.|:||.||:||..|:.|:::|:.|||.:|.|
  Rat   780 SYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQ 844

  Fly  2456 AQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEI 2520
            |..|.:|.||:|...||||:...|.|::::|:...|.|:...|:..:|..       ...::||:
  Rat   845 AVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPM-------LNFTRKEV 902

  Fly  2521 EDLL----KKGAYGAVMDDDNAGDKFCEEDIDSILK----RRTQVITMESEKGSTFSKASFAASG 2577
            |:||    |:.|....:  |..|.|      :|:|:    :...:||.|     .|...|...
  Rat   903 ENLLHFVEKEPAPQTSL--DIKGIK------ESVLQLACLKYPHLITKE-----PFEHESLLL-- 952

  Fly  2578 NRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNE 2642
            ||.|..:      ||..||      |.::...||...|.|..|....:|.......|.|..:.::
  Rat   953 NRKDHKL------TKAEKK------AAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQ 1005

  Fly  2643 NSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAA----------LGLEEIQYGNWAKS 2697
                              |:.....||:|:.:...|...:.          ||.......|...|
  Rat  1006 ------------------RNWQPTLKGDDKPVASVRPVQSTPIPMMPRHVPLGGSVSSASNTNPS 1052

  Fly  2698 ECFKV----EKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIW 2758
            ..|.:    ..|:|.......::::..|...    ..||:  |||.....:.:.:|.:  .|:|
  Rat  1053 MNFPINYLQRAGVLVQKVVTTTDIVIPGLNS----STDVQ--ARISAGESIHIIRGTK--GTYI- 1108

  Fly  2759 DLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSA 2823
                .|.||.:..:              |..||......| ...|.||...|.:..:...|.:|:
  Rat  1109 ----RTSDGRIFAV--------------RATGKPKAPEDG-RMAASGSQGPSLASTSNGRHSASS 1154

  Fly  2824 LDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYY 2888
            ....|.:.        .|...|...|...|:.::|   |.:..|.:.|
  Rat  1155 PKAPDPEG--------LARPVSPDSPEIISELQQY---ADVAAARESH----------------- 1191

  Fly  2889 IQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRAD 2953
                          .|:|.....:..||..           ..|.|.:.||         .:..:
  Rat  1192 --------------QNSPSISAALPGPPAQ-----------LMDNSTIPGT---------ALGTE 1222

  Fly  2954 PNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSL 3018
            |.|      |.......|.||..|     ::.:|...|.........|.......:.....|..|
  Rat  1223 PCL------GGHCLNSSLLVTGQP-----SSGRHPVLDLRGHKRKLATPSVSQESVRRRSRKGHL 1276

  Fly  3019 LDPERPSSSGKSSSENASGG--NDKTESENDATT--VSESSYKSEVLPGKGSDLDVSVAQQDALS 3079
            ..|.:|...|..    .|||  .......::.||  .|::...|..:....|...:|....||..
  Rat  1277 PAPVQPYEHGYP----VSGGFSMPPVSLNHNLTTPFTSQAGENSLFMGSNPSYYQLSNLLADARL 1337

  Fly  3080 ATPELANTSDPKMNKNDAQVSASVSCDPADSSSP 3113
            ..|.   |:||.:..  ..||:|.:.....:|:|
  Rat  1338 VFPV---TTDPLVPA--GPVSSSSTATSVTASNP 1366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	44/212 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	10/72 (14%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	17/61 (28%)
		PLN03142	2029..>2606	CDD:215601	177/741 (24%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Rad54l2	NP_001127992.2	HepA	109..889	CDD:440319	191/835 (23%)
		DEXHc_ARIP4	270..546	CDD:350827	63/275 (23%)
		PHA03247	<1111..1429	CDD:223021	64/353 (18%)