Protein Alignment kis and Smarca2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001004446.2
• Gene: Smarca2 / 361745
• RGDID: 1302988
• Length: 1597
• Species: Rattus norvegicus
• Alignment Length: 2358
• Identity: 489/2358 - (20%)
• Similarity: 731/2358 - (31%)
• Gaps: 1066/2358 - (45%)

  Fly   409 SPRPPTMSPHPQMSPRP-------VGVSPAKPPPPQQQQQQTQAQQPQQVVSNQPSQHSIQGMVG 466
            :|..|...|||..||.|       :|.||...|.|                   .|.||:.|
  Rat     3 TPTDPAAMPHPGPSPGPGPSPGPILGPSPGPGPSP-------------------GSVHSMMG--- 45

  Fly   467 LPSPRPQPPTSGAGGAGAKGPAPVAAPVNTLQALEQMVMPSQALGLPPMDYPSAYRSAVGPRMPA 531
             |||               ||..|:.|::|:.:.:   .|.:.|
  Rat    46 -PSP---------------GPPSVSHPMSTMGSAD---FPQEGL--------------------- 70

  Fly   532 SPQQQQQQHQQWGAAHGAQHLAALQQQQAQQQQQQVQQQQQAPPQQQQQAAMLQAQQQHHQQQLS 596
                 .|.|:.....|....:..:.....:....:.......|||        ....||.|..:|
  Rat    71 -----HQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPPHPGMGPPQ--------SPMDQHSQGYMS 122

  Fly   597 MYGQPMGQQPQTAQQQVVPPVTS---QPPVVAASQQQQQQQHQQQSLNDQLQHSINDIVGGGNSS 658
            .:..|:|     |.:.|..|::.   .||.:..||.........|::|..            |..
  Rat   123 PHPSPLG-----APEHVSSPISGGGPTPPQMPPSQPGTLIPGDLQAMNQP------------NRG 170

  Fly   659 GATGGAQNQHQQQPQLAAMSSPLHQQNLPNMHHLIQPTMETTQPTQQQQQTSQQQQQPQQPQATL 723
            .:.......||.:.|:.|.......|.||          ||.|...|.::|
  Rat   171 PSPFSPVQLHQLRAQILAYKMLARGQPLP----------ETLQLAVQGKRT-------------- 211

  Fly   724 TSPHHQQMQHQSPIHQQQQSPHHQQHLPSYNQSQQQFDPFANILGDNQPAASQQTMSPAHVSSPV 788
                                      ||...|.|||
  Rat   212 --------------------------LPGMQQQQQQ----------------------------- 221

  Fly   789 PAQMQQQQHQTQQQPSQQVPQSQQQQVSQPQQQTQQQQPSTPSHHLSSILNETANSNDSSTLAVA 853
              |.||||.|.|||| ||..|.|||..:|||||.||||
  Rat   222 --QQQQQQQQQQQQP-QQPQQPQQQTQAQPQQQQQQQQ--------------------------- 256

  Fly   854 ANDSNNSSSNSSTNSIVNNQPTSVHDSNSQSSINSSSNNQQQLLMDNTNSHGGNSESAQNAGVDV 918
                               ||.::      .|.|..|...|:|||           :|||
  Rat   257 -------------------QPPAL------VSYNRPSGPGQELLM-----------TAQN----- 280

  Fly   919 GLFDNNSMSSNSAAVAAVASNAASAAAALLDSNSQSSNAEFEKNQSEGEGLGVVEGVIANETDLP 983
                                                                             
  Rat   281 ----------------------------------------------------------------- 280

  Fly   984 QDENSVSKTQDITLSTELPTIQDDLQEKPTAEMEQTQLGQSLGDLSKSLLEEPKTVEESGEDKSQ 1048
                    ||. .||...|                                       ||.
  Rat   281 --------TQQ-KLSAPAP---------------------------------------SGR---- 293

  Fly  1049 SAPGVAPPADPIIPVTQP-------PQQQMPPIGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGAP 1106
              |..||||     .|||       |..|.|..|.|    :|..:.| |.|..:.|:..|.|
  Rat   294 --PSPAPPA-----ATQPTATAVPGPSVQQPAPGQP----SPVLQLQ-QKQSRISPIQKPQG--- 343

  Fly  1107 GMYPPYPMLHQQEI---AALQQQIQELYCMPPGHELQHQDKLMRMQERLNLLTQHEVNDQCAGGP 1168
              ..|..:|.::|.   |.:..:||||..:|
  Rat   344 --LDPVEILQEREYRLQARIAHRIQELESLP---------------------------------- 372

  Fly  1169 QCLLFQNVPPMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLM 1233
                 .::||
  Rat   373 -----GSLPP------------------------------------------------------- 377

  Fly  1234 DISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTST 1298
                                      |..|:...:...:.:|.:..   .|.|:|.:....||:.
  Rat   378 --------------------------DLRTKATVELKALRLLNFQR---QLRQEVVACMRRDTTL 413

  Fly  1299 DGSGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGA 1363
            :.:...|                                             |.||.|:.....|
  Rat   414 ETALNSK---------------------------------------------AYKRSKRQTLREA 433

  Fly  1364 EQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGD 1428
            ..|   .::|..:.:                                       .::.|..:...
  Rat   434 RMT---EKLEKQQKI---------------------------------------EQERKRRQKHQ 456

  Fly  1429 ETVDSVPDSAGDPAS---TPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRI 1490
            |.::|:...|.|...   :.:.:.:|.|.|.:..:||:|........|       ::|.|.|..:
  Rat   457 EYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETER-------IEKERMRRLM 514

  Fly  1491 VPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDD----------ENS 1545
            ..:.:|....:|:                    :..:|..|    :|:.:|:          |:.
  Rat   515 AEDEEGYRKLIDQ--------------------KKDRRLAY----LLQQTDEYVANLTNLVWEHK 555

  Fly  1546 LLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTS 1610
            ...|:..||.::.....:..||    |..||..|.:|:            |:|||||
  Rat   556 QAQAAKEKKKRRRRRKKAEENA----EGGEPALGPDGE------------PIDESSQ-------- 596

  Fly  1611 AVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQD 1675
                             ||..|..|
  Rat   597 -----------------MSDLPVKV---------------------------------------- 604

  Fly  1676 EEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEP--DDSKKSDEDN 1738
                                 |..|:.|.|...|..|    |.::|:..|..|  :.:.:||.:.
  Rat   605 ---------------------THTETGKVLFGPEAPK----ASQLDAWLEMNPGYEVAPRSDSEE 644

  Fly  1739 KDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLE--KMEV 1801
            .:.|..|.|:|     :||..:|..|.:..:.||:.:.|            |:.:.::|  |.:|
  Rat   645 SESDYEEEDEE-----EESSRQETEEKILLDPNSEEVSE------------KDAKQIIETAKQDV 692

  Fly  1802 DEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEA 1866
            |    |:.|....|.||
  Rat   693 D----DEYSMQYSARGS------------------------------------------------ 705

  Fly  1867 DMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIE 1931
                         :.|:.                        ||..|....:|||..|
  Rat   706 -------------QSYYT------------------------VAHAISERVEKQSALL------- 726

  Fly  1932 DEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNK 1996
                                   .:| |.||
  Rat   727 -----------------------ING-TLKH---------------------------------- 733

  Fly  1997 IPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKT 2061
                                               |||:||.|:...:.|..|.|||||||||||
  Rat   734 -----------------------------------YQLQGLEWMVSLYNNNLNGILADEMGLGKT 763

  Fly  2062 IQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGWTDMNV-VVYHGSVTSKQMIQDYEYYY 2124
            ||::..:..:.|: .:.||:|:|.||||:.||..||:.|....| :.|.|:...::.:..
  Rat   764 IQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVP----- 823

  Fly  2125 KTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH 2189
            :..||       |||||:||:|.|:.|...|....|:..::||.||:||.:|||.:   .||..:
  Rat   824 QLRSG-------KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ---VLNTHY 878

  Fly  2190 ----RVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE---VN 2237
                |:||:||||||.:.||::|||||.|:.|.|...|...|.:          |..||.   :.
  Rat   879 VAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIR 943

  Fly  2238 KLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYR-----GIL-----EQNFSFLKK 2292
            :|..:|:|.:|||||.:||..|..|.|.:|:.:::.:||..||     |||     |::    ||
  Rat   944 RLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKD----KK 1004

  Fly  2293 GTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKN-------LILSAG 2350
            |...|.  .||||:|:|||.|.|||:....||    .|....|      |.|       |..::|
  Rat  1005 GKGGAK--TLMNTIMQLRKICNHPYMFQHIEE----SFAEHLG------YSNGVINGAELYRASG 1057

  Fly  2351 KMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKP 2415
            |..|:|::||||:|..||||:|.||...:.|:|||..:|.:.:.|:||..:...|...:.::::|
  Rat  1058 KFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEP 1122

  Fly  2416 GSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTY 2480
            ||..|:|||.|:|||||:||.|||||:|:||||||..|||||.|.|||||:..|::.||...|:.
  Rat  1123 GSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSV 1187

  Fly  2481 EREMFDKASMKLGLDKAVLQS-MNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFC- 2543
            |.::...|..||.:|:.|:|: |..|.|.....:...:..:|...:......|.||:.......
  Rat  1188 EEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIAR 1252

  Fly  2544 -EEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERD 2607
             ||:.|..::       |:.::     :...|.:..|....::: |....|..|.|.:.:....:
  Rat  1253 REEEFDLFMR-------MDMDR-----RREDARNPKRKPRLMEE-DELPSWIIKDDAEVERLTCE 1304

  Fly  2608 ETEDLVLSEPRRRTQIKRYGHEDVME----LNSEESSN-ENSDEEGGIGLRSRRR-------KEK 2660
            |.|:.:.....|  |.:...:.|.:.    |.:.|..| |..:||..:..|.|||       ||.
  Rat  1305 EEEEKIFGRGSR--QRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKED 1367

  Fly  2661 RDRAREKKGNDEYIPRER 2678
            .::|::::|..   |.|:
  Rat  1368 VEKAKKRRGRP---PAEK 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830	27/130 (21%)
		Med15	<1056..>1265	CDD:312941	30/218 (14%)
		PRK12678	1319..>1500	CDD:237171	23/183 (13%)
		PTZ00121	<1419..1923	CDD:173412	82/520 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	4/66 (6%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	4/57 (7%)
		PLN03142	2029..>2606	CDD:215601	223/615 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Smarca2	NP_001004446.2	PHA03378	<74..389	CDD:223065	116/743 (16%)
		QLQ	173..207	CDD:462622	10/43 (23%)
		HSA	443..515	CDD:214727	15/117 (13%)
		BRK	596..639	CDD:462196	15/132 (11%)
		DEXHc_SMARCA2	708..958	CDD:350821	105/388 (27%)
		PLN03142	727..>1209	CDD:215601	210/582 (36%)
		SnAC	1266..1333	CDD:464219	11/74 (15%)
		Bromodomain	1340..>1426	CDD:445827	14/46 (30%)
		Bromo_SNF2L2	1389..1513	CDD:99947