Protein Alignment kis and smarca4a

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_853634.1
• Gene: smarca4a / 353295
• ZFINID: ZDB-GENE-030605-1
• Length: 1627
• Species: Danio rerio
• Alignment Length: 2153
• Identity: 478/2153 - (22%)
• Similarity: 770/2153 - (35%)
• Gaps: 719/2153 - (33%)

  Fly  1072 PPIGMPMHPIAPGYEAQAQGQGHMPPMM------PPYGGAPGMYPPYPMLHQQEIAALQQQIQEL 1130
            ||:|....|      ..:.|.|..|..|      |..|.|.||..|.|
Zfish     6 PPMGGTPRP------GPSPGPGPSPGAMLGPSPGPSPGSAHGMMGPSP----------------- 47

  Fly  1131 YCMPP--GHELQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLLNQQMV 1193
              .||  ||.|                                     ||. ||.|.|..|...:
Zfish    48 --GPPSSGHPL-------------------------------------PPQ-GPSGYPQDNMHQM 72

  Fly  1194 ESPQVSSTTGRGRGKSANKPRKPRAKKG--EKAQVGQQQDL-MDISGNVAMGAANAVSSIPTTQL 1255
                             :||.:...:||  |..:.||.:.: |...|:..||..
Zfish    73 -----------------HKPMEGMHEKGIPEDQRYGQMKGMGMRQGGHSGMGPP----------- 109

  Fly  1256 PVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDGSGKKKKPRKPRTPKDPNKPP 1320
            |...|..:||           |...:|                   |....|    :|...|.|
Zfish   110 PSPMDQHSQG-----------YPSPLG-------------------GSDHAP----SPVPANGP- 139

  Fly  1321 RDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSA 1385
                        |:.|.....|.|:....|..:...|....|    |.|.          .||..
Zfish   140 ------------PSGPMMPSGPGAMPMEGGDPQAMAQQNRSG----GAGG----------VAGPG 178

  Fly  1386 DGEAETTSGGTGVDGESPDYDD----------IPVSKIPRG---------SNEDEKEAEAGDETV 1431
            .......:||.|..|....::.          :....:.||         :.:.::......:.:
Zfish   179 PSGGPPNAGGPGGAGGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQGM 243

  Fly  1432 DSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDG 1496
            .::|.::|..|..|                     |......|..:     ..|..|.:.|
Zfish   244 PNMPPASGQGAGPP---------------------GPGVPGPGGPN-----YNRPHGMVGP---- 278

  Fly  1497 EDDTLDRTPPPSP---PPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKP 1558
                  ..|||.|   ||      ..:....|...|.:.:..|:..:...::.....|.:...:|
Zfish   279 ------NMPPPGPSGVPP------GLQGQPTNGPPKPWPEGPMVNAAAPASAPQKLIPPQPTGRP 331

  Fly  1559 S-ANASNSNAGSDVEKTEPQSGAEGDAAQE--VGEEKSN--LPLDESSQLEASSSTSAVAEKERQ 1618
            | |..|...|.|.|  ..||:.:.|..||.  |..:|.|  .|:.:...|:   ....:.|:|.:
Zfish   332 SPAPPSVPPAASPV--MPPQTQSPGQPAQPPMVLHQKQNRITPIQKPRGLD---PVEILQEREYR 391

  Fly  1619 ISTDAAN--AAMSSKPNYVYINTGD------EDSMVVQLVLAMRMGKRELILDKPKEKAPEP--- 1672
            :....|:  ..:.:.|..:   .||      .:...::|:...|..::|:::...::.|.|.
Zfish   392 LQARIAHRIQELENLPGSL---AGDLRTKANIELKALRLLNFQRQLRQEVVVCMRRDTALETALN 453

  Fly  1673 ----KQDEEKSELDEATTDKPEGDEKFKTEGESK--------------KDLTD------SEETKL 1713
                |:.:.:|..:...|:|.|..:|.:.|.:.:              ||..:      ::..||
Zfish   454 AKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSITAKMQKL 518

  Fly  1714 ESSAMEVDSKEESEPDDSKKSDEDNKDKDKME---VDDEVG-------KSDKE-----SKPEEQ- 1762
            ..:.....:..|.|    :|.:.:..:|::|.   .:||.|       |.||.     .:.:|.
Zfish   519 TKAVATYHANTERE----QKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYV 579

  Fly  1763 ---SETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTD 1824
               :|.|:..:.::|:::.|..     ...|:||                    .|||.......
Zfish   580 ANLTELVRAHKAAQALKDKKKK-----KKKKKPE--------------------NAEGGAPALGP 619

  Fly  1825 DSNPEEATTEKNK---ESLEIEGEK-----ERVKEGE---------------ESVKKENDEKTEA 1866
            |..|.:.|::.:.   :.:.::..|     :..|.|:               .|..:::....|.
Zfish   620 DGEPLDETSQMSDLPVKVIHVDSGKILTGMDAPKAGQLDTWLEMNPGYEVAPRSDSEDSGSDEEE 684

  Fly  1867 DMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIE 1931
            |.|.:|:|.....||                                              :.:.
Zfish   685 DDEEEPQPSQAPTEE----------------------------------------------KKVI 703

  Fly  1932 DEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNK 1996
            .:|.::|.:|||                .:|.:        |....:::::..|....:.|
Zfish   704 PDPDSEDVSEVD----------------ARHII--------EHAKQDVDDEYGNSAFIRGL---- 740

  Fly  1997 IPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKT 2061
                   :|.......:.:|:||.........|:.||::||.||...:.|..|.|||||||||||
Zfish   741 -------QSYYAVAHAVTEKVEKQSSLLVNGQLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKT 798

  Fly  2062 IQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGWTDMNV-VVYHGSVTSKQMIQDYEYYY 2124
            ||::..:..:.|: .:.||||:|.||||:.||..||:.|....| |.|.||..:::...
Zfish   799 IQTIALITYLMEFKRLNGPFLIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFL------ 857

  Fly  2125 KTESGKVLKEPI----KFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQL 2185
                      ||    |||||:||:|.|:.|...|....|:..::||.||:||.:|||.:.|...
Zfish   858 ----------PILRSGKFNVLVTTYEYIIKDKQVLAKLRWKYMIVDEGHRMKNHHCKLTQVLNTH 912

  Fly  2186 NL-EHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE---V 2236
            .| ..||||:||||||.:.||::|||||.|:.|.|...|...|.:          |..||.   :
Zfish   913 YLAPRRVLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILII 977

  Fly  2237 NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYR-----GIL-----EQNFSFLK 2291
            .:|..:|:|.:|||||.:||..|..|.|.:|:.:::.:|:..||     |:|     |::    |
Zfish   978 RRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKD----K 1038

  Fly  2292 KGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQH---------GEDPESYYKNLIL 2347
            ||  ......||||:|:|||.|.|||:....||..     |:|         |.|       |..
Zfish  1039 KG--KGGTKTLMNTIMQLRKICNHPYMFQHIEESF-----SEHLGFTGGIVQGSD-------LYR 1089

  Fly  2348 SAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRY 2412
            ::||..|:|::||||:|..|:||:|.||...:.|:|||..||.:.:.|:||..:...|...:..:
Zfish  1090 ASGKFELLDRILPKLRATNHKVLLFCQMTTLMTIMEDYFAYRNFKYLRLDGTTKAEDRGMLLKNF 1154

  Fly  2413 SKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCR 2477
            :.|....|:|||.|:|||||:||.:||||||:||||||..|||||.|.|||||:..|::.||...
Zfish  1155 NDPSHQYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTV 1219

  Fly  2478 NTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKF 2542
            |:.|.::...|..||.:|:.|:|                                     ||
Zfish  1220 NSVEEKILAAAKYKLNVDQKVIQ-------------------------------------AG--- 1244

  Fly  2543 CEEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERD 2607
                             |..:|.|:..:.:|..:....:                       |:|
Zfish  1245 -----------------MFDQKSSSHERRAFLQAILEHE-----------------------EQD 1269

  Fly  2608 ETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNE---NSDEEGGIGLR---SRRRKEKRDRARE 2666
            |.||                     |:..:|:.|:   .|:||....:|   .|||:|.|:
Zfish  1270 EEED---------------------EVPDDETVNQMIARSEEEFDHFMRMDLDRRREEARN---- 1309

  Fly  2667 KKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWR--- 2728
                    |:.|..|    :||.:...|...:..:||:        ...|..|...|.||.|
Zfish  1310 --------PKRRPRL----MEEDELPTWIMKDDAEVER--------LTCEEEEEKMFGRGSRQRK 1354

  Fly  2729 DVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSN 2793
            :||..|..             .||    .|  :...|:|.:.:|..:        .|.:...:..
Zfish  1355 EVDYSDSL-------------TEK----QW--LKAIEEGTLDEIEEE--------VRHKKTTRKR 1392

  Fly  2794 KESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPN--HWSKKE 2856
            |....:..|.|  |:.|:||.:           .|||..|...............||  ..:||.
Zfish  1393 KRDRDLDLPGP--ATPSSSGRS-----------RDKDDDGKKQKKRGRPPAEKLSPNPPSLTKKM 1444

  Fly  2857 KYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQV 2921
            |...||.::  ||...||..::|.:::.     ..:.:.::.:.|:  .|:....|:     :::
Zfish  1445 KKTVDAVIK--YKDGNGRQLSEVFIQLP-----SRKELPEYYELIR--KPVDFRKIK-----ERI 1495

  Fly  2922 PSSWW---NPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSL------P 2977
            .|..:   |.:..|..||       |:..:....:.:|.:         .|.:.:.|:      .
Zfish  1496 RSHKYRSLNDLEKDVMLL-------CQNAQTFNLEGSLIY---------EDSIVLQSVFTSVRQK 1544

  Fly  2978 INEDDANSKHDDGDEVDDD---GTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGN 3039
            |.:::..|:.||.:|.:||   |:.:...|...|:. ...||.....:....:|:||.......:
Zfish  1545 IEKEEEESEGDDSEEEEDDVDEGSESESRSVKVKIK-LSRKDKAERGKGRRRTGRSSRPKPVVSD 1608

  Fly  3040 DKTESEND 3047
            |.:|.:.:
Zfish  1609 DDSEEDQE 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	40/203 (20%)
		PRK12678	1319..>1500	CDD:237171	27/199 (14%)
		PTZ00121	<1419..1923	CDD:173412	94/588 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	9/81 (11%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	8/57 (14%)
		PLN03142	2029..>2606	CDD:215601	212/615 (34%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarca4a	NP_853634.1	Med15	<65..>360	CDD:312941	72/427 (17%)
		QLQ	198..231	CDD:462622	2/32 (6%)
		Smc	<382..>624	CDD:440809	45/273 (16%)
		HSA	478..550	CDD:214727	11/75 (15%)
		BRK	629..672	CDD:462196	3/42 (7%)
		DEXHc_SMARCA4	743..993	CDD:350820	101/265 (38%)
		PLN03142	762..>1244	CDD:215601	206/552 (37%)
		SnAC	1301..1368	CDD:464219	25/109 (23%)
		Bromo_SNF2L2	1440..1545	CDD:99947	22/134 (16%)