DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kis and Etl1

DIOPT Version :9

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	896	Identity:	264/896 - (29%)
Similarity:	415/896 - (46%)	Gaps:	209/896 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1686 TDKPEGDEKFKTEGESKKDLTDSE---ETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVD 1747
            |::..|.::.:...:|..|..||:   :||||   :.|..|||.....:|.|..    .|.|.:.
  Fly    44 TERVPGKKRIQVMADSDSDGNDSQTPKKTKLE---LTVKEKEERYMAAAKISPH----FDTMAIQ 101

  Fly  1748 DEVGKS--DKESKPEEQSETVKTEENSKAIEEDK---SSTVLTADHAKEPETVLEKMEVDEKAND 1807
            :.:.::  |..:......|..|.:.::..:.:.|   .|..::..:..:          ::.::|
  Fly   102 ESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSD----------NDHSDD 156

  Fly  1808 DQSAVSKAEGSDEKSTDDSNPEEAT--TEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMEN 1870
            |....||.:..|   :|||:.|.:|  |.:.|:..:...|...::  .:|||..:::|..|.::.
  Fly   157 DDVKQSKDQVYD---SDDSDSEMSTKMTGQRKKVFQFMNEASLIE--LQSVKTLSEKKALAIIDV 216

  Fly  1871 KPEPVFIDVEEYFVKYR------NFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFEN 1929
            :|...:.|:.:.....|      |::         :||:.....|||.:.:.....|:
  Fly   217 RPFSDWSDLRQKLESIRMSGDLLNYA---------QELINKQNTVAAILSKCNNMVSR------- 265

  Fly  1930 IEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDK--IEQYL 1992
                                                             ||:.:.|..  :||
  Fly   266 -------------------------------------------------LEKAISNGAGIVEQ-- 279

  Fly  1993 RFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMG 2057
                              |:|         ...|..|..||:.|||||........|.|||||||
  Fly   280 ------------------PKL---------LSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMG 317

  Fly  2058 LGKTIQSLTFVHSVYEYGI-RGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQDY 2120
            ||||||.:.|:..:.|.|: :...|::.|.||:.||:.|...| .::.|..||||...::.::
  Fly   318 LGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMR-- 380

  Fly  2121 EYYYKTESGKVLKEPIK-FNVLITTFEMIVTDYMDLKAFNWRLC-----VIDEAHRLKNRNCKLL 2179
                    |:..|:... |:||:||:.::.:...:.|.|  |:|     :.||||.|||...:..
  Fly   381 --------GRFAKDGFTGFDVLLTTYHIVGSTPEERKMF--RVCKLDYVIFDEAHMLKNMTTQRY 435

  Fly  2180 EGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFS-SQEEFMSEFG------------SLR 2231
            ..|..:|...|:||:|||||||:.||.|||.|:.|..|: |.|:..|.|.            |..
  Fly   436 ANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQF 500

  Fly  2232 TEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIE-VELTNIQKKYYRGILEQNFSFLKKGTT 2295
            .|.::.:.:.::||.:|||||.||.|:| ||:.:::| |.:::.||.||..:::. :|..|....
  Fly   501 QETQIQRAKRIMKPFVLRRLKKDVLKNL-PKKLSLVEKVPMSSQQKIYYHELVDY-YSNNKGEVC 563

  Fly  2296 SANIPNLMNTMMELRKCCIHPYL---------LNGAEEQI-----------QY---------DFK 2331
            |::....:..|||:|:...||.|         |.|..:::           ||         ||:
  Fly   564 SSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQ 628

  Fly  2332 SQHGEDPESYY-----KNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKY 2391
            .....:...:|     .|||..:||.:.:|.|||||||.|||||:|||....|||:|:||..||:
  Fly   629 VYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKF 693

  Fly  2392 PFERIDGRIRGNLRQEAIDRYSKPGSDR-FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQ 2455
            .|.|:||....|:||:.|..::  |.|. |||||.|||||:|||||||||.:|:|.|:||.||.|
  Fly   694 GFCRLDGATAVNVRQDLITDFN--GDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQ 756

  Fly  2456 AQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQG 2506
            |:.||||:||::.|.||||:..:|.|..:...|..||.|:|.:  :.|.:|
  Fly   757 AEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDI--TSNEKG 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	23/107 (21%)
		HepA	1676..2527	CDD:223627	264/896 (29%)
		SDA1	<1693..>1854	CDD:283052	34/170 (20%)
		CHROMO	<1879..1919	CDD:237991	7/45 (16%)
		Chromo	1941..1996	CDD:278797	5/56 (9%)
		DEXDc	2048..2197	CDD:238005	54/156 (35%)
		Helicase_C	2350..2464	CDD:278689	68/114 (60%)
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	109/308 (35%)
		DEXDc	308..453	CDD:238005	54/156 (35%)
		Helicase_C	651..765	CDD:278689	68/115 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467111
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840