Protein Alignment kis and smarca2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_073805988.1
• Gene: smarca2 / 334032
• ZFINID: ZDB-GENE-030131-5964
• Length: 1578
• Species: Danio rerio
• Alignment Length: 1903
• Identity: 450/1903 - (23%)
• Similarity: 726/1903 - (38%)
• Gaps: 502/1903 - (26%)

  Fly  1072 PPIGM------PMHPIAPG-YEAQAQGQGHMP----PMMPPYGGAPGMYPPYPMLHQ------QE 1119
            ||:||      |...::|| ....:.|.|..|    .||.|..|.|.:  |:.|..|      ||
Zfish     7 PPVGMSHAGPSPGAGLSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSV--PHTMQGQGAGEYSQE 69

  Fly  1120 IAALQQQIQELYCMPPGHELQHQDKLMRMQER-LNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPP 1183
            :..:.:.::.:      ||....|.:...|.: :.:.:.|    ...|.||..:.|:......|.
Zfish    70 MHPMHKPMEGM------HEKAMADDIHYGQMKGVGMRSLH----SGMGPPQSPMDQHSQGYMSPH 124

  Fly  1184 GNPLLN-QQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLMDISGNVAMGAANAV 1247
            .:|:.. .:.|.||.           |...|..|:..:|:...:......|   |..|.| .:|.
Zfish   125 PSPMGQVPEHVPSPM-----------SGGGPTPPQMSQGQSPMMPMDPQGM---GQQARG-QSAF 174

  Fly  1248 SSIPTTQLPVSEDCVTQGAGDTSVVGMLEYS-EGMGD-LSQDVHSANELDTSTDGSGKKKKPRKP 1310
            |.:...||...               :|.|. .|.|. |.:::..|.:        ||:..|...
Zfish   175 SPVQLQQLRAQ---------------ILAYKILGRGQPLPENLQLAVQ--------GKRSLPTMQ 216

  Fly  1311 RTPKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDN 1375
            :.|  .|..|.:|.|....|.  ..|.|.:..:...:....|...||:.|      |:|:|.
Zfish   217 QQP--VNTGPFNRPPGMPMPH--GGPASGQCLSPAMQTHTQSSGPKQWTE------GQGAET--- 268

  Fly  1376 KPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGD 1440
                    |:..:....|..:|....:|.........:|..|...:.:.:.        |...|.
Zfish   269 --------SSTPQKLLISAPSGRPSPAPPLAPTGTQPVPSTSLTSQPQPQP--------PAGPGQ 317

  Fly  1441 PASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKR--RNRGRIVPESDGEDDTLDR 1503
            |:.....:.::....            ..:|.:|....:.|::|  |.:.||..... |.:.|
Zfish   318 PSLIIQLQQKQNRVT------------PIQKPQGLDPVELLQEREYRLQARIAHRIQ-ELENL-- 367

  Fly  1504 TPPPSPPPDSEMDSN---KRRSSRNTQRKKYIDDV-MLRFSDDENSLLVASPVKKDKKPSANASN 1564
              |.|.|||....:.   |.....|.||:..:|.| .:|......:.|.:...|:.|:.:...:.
Zfish   368 --PGSLPPDLRTKATVELKALRLLNFQRQLRLDVVACMRRDTTLETALNSKAYKRSKRQTLREAR 430

  Fly  1565 SNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMS 1629
            .     .||.|.|        |::.:|:                      |.||...:..|:.:.
Zfish   431 M-----TEKLEKQ--------QKIEQER----------------------KRRQKHQEYLNSILQ 460

  Fly  1630 SKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEK 1694
            ...::...:......:       .::.|.........|:  |.|::.|:.|.:.......|.:|.
Zfish   461 HAKDFKEYHRSISGKI-------QKLSKAIATWHTNTER--EQKKETERIEKERMRRLMAEDEEG 516

  Fly  1695 FKTEGESKKD------LTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKS 1753
            ::...:.|||      |..::|.....:.:..:.|......:.||    .:.|.|.|..|..|..
Zfish   517 YRKLIDQKKDKRLAYLLQQTDEYVANLTELVYEHKAAQAAKEKKK----KRKKKKKEAGDAEGMG 577

  Fly  1754 ---------DKESKPEE------QSETVKTEENSKAIEEDKSSTVLTADHAKE--PETVLEKMEV 1801
                     |:.|:..|      |:||.|..:.:.|.:..:....|..:...|  |.:..|:...
Zfish   578 AIGPDGEPIDENSQMSELPVKVIQTETGKVLQGTDAPKSSQLEAWLEMNPGYEVAPRSDSEESGS 642

  Fly  1802 DEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEA 1866
            |.:..||:..||:|| |:||...|.|.:|.:....|..:|
Zfish   643 DFEEEDDEEVVSRAE-SEEKKVIDPNSDEVSETAAKHIIE------------------------- 681

  Fly  1867 DMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIE 1931
                                                       :||               ::::
Zfish   682 -------------------------------------------SAK---------------QDVD 688

  Fly  1932 DEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNK 1996
            ||..:|                  :|:|:        |..|......:.|.||
Zfish   689 DEYSSQ------------------AGQTS--------SQSYYGVAHAVIERVD------------ 715

  Fly  1997 IPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKT 2061
                                  |...:....:|:.||::||.|:...:.|..|.|||||||||||
Zfish   716 ----------------------KQSTFLINGTLKQYQIQGLEWMVSLYNNNLNGILADEMGLGKT 758

  Fly  2062 IQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGWTDMNV-VVYHGSVTSKQMIQDYEYYY 2124
            ||::..:..:.|: .:.||:|:|.||||:.||..|.:.|....| :.|.|:.:.::.:..
Zfish   759 IQTIGLITYLMEHKRLNGPYLIIVPLSTLSNWVYELDKWAPSIVKIAYKGTPSMRRSLVP----- 818

  Fly  2125 KTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH 2189
            :..||       ||||||||:|.|:.|...|....|:..::||.||:||.:|||.:   .||..:
Zfish   819 QLRSG-------KFNVLITTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ---VLNTHY 873

  Fly  2190 ----RVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE---VN 2237
                |:||:||||||.:.||::|||||.|:.|.|...|...|.:          |..||.   :.
Zfish   874 VAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIR 938

  Fly  2238 KLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYR-----GIL-----EQNFSFLKK 2292
            :|..:|:|.:|||||.:||..|..|.|.:|:.:::.|||..||     |||     |::    ||
Zfish   939 RLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSAIQKVLYRHMQGKGILLTDGSEKD----KK 999

  Fly  2293 GTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYK--NLILSAGKMVLI 2355
            |...|.  .||||:|:|:|.|.|||:....||..     ::|...|.....  :|..::||..|:
Zfish  1000 GKGGAK--TLMNTIMQLKKICNHPYMFQHIEESF-----AEHLGFPNGIISGPDLYRASGKFELL 1057

  Fly  2356 DKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRF 2420
            |::||||||..||||:|.||...:.|||||..||.:.:.|:||..:...|...:.::::.||..|
Zfish  1058 DRILPKLKATNHRVLLFCQMTSLMTILEDYFGYRNFLYLRLDGTTKSEDRAMLLKKFNEEGSQYF 1122

  Fly  2421 VFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMF 2485
            :|||.|:|||||:||.|||||:|:||||||..|||||.|.|||||:..|::.||...|:.|.::.
Zfish  1123 IFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKIL 1187

  Fly  2486 DKASMKLGLDKAVLQS-MNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAG---------- 2539
            ..|..||.:|:.|:|: |..|.|.....:...:..:|...:......|.||:...
Zfish  1188 AAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQNMEEDEVPDDETLNQMIARNEDEF 1252

  Fly  2540 DKFCEEDIDS-----------------------ILKRRTQV--ITMESEKGSTFSKASFAASGNR 2579
            :.|...|:|.                       |||...:|  :|.|.|:...|.:    .|.:|
Zfish  1253 ELFMRMDLDRRREDARNPKRKPRLMEEDELPSWILKDDAEVERLTCEEEEEKIFGR----GSRHR 1313

  Fly  2580 SDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNENS 2644
            .|:...|.....:|.:.::   |....:..|::.|...:||    |:..:||
Zfish  1314 RDVDYSDALTEKQWLRAIE---DGNLEEIEEEIRLKRRKRR----RHVDKDV------------- 1358

  Fly  2645 DEEGGIGLRSRRRKEKRDRAREKKG---------NDEYIPRERDALAALGLEEIQYGNWAKSECF 2700
                        |:|..|:|::::|         |...:.::.:|:....:..........||.|
Zfish  1359 ------------RREDGDKAKKRRGRPPAEKLSPNPPKLTKQMNAIVDTVINYRDISGRQLSEVF 1411

  Fly  2701 ---KVEKGLLSFGWGRWSELL-------ELGQFKRGWRDVDVEDCARIILLYC--LQVY--KGDE 2751
               ...|.|     ..:.||:       ::.:..|..:...|.|..:.::|.|  .|.|  :|.:
Zfish  1412 VQLPSRKEL-----PEYYELIRKPVDFKKIKERVRSHKYRSVSDLEKDVMLLCHNAQTYNLEGSQ 1471

  Fly  2752 KIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTP---APGSASGSNSG 2813
            ..:..|  ::........|||:|:.|...:  .......:|.:||..|...   :.....|.:.|
Zfish  1472 IYEDSI--VLQSVFKSARQKIAREESDDES--DDDDEEDESEEESKSVKVKIKLSKRDERGQDKG 1532

  Fly  2814 NTTPAHKSSALDGSDKDS 2831
            ...|:...:....||.||
Zfish  1533 KKRPSRGKAKPVVSDDDS 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	46/211 (22%)
		PRK12678	1319..>1500	CDD:237171	30/182 (16%)
		PTZ00121	<1419..1923	CDD:173412	87/532 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	2/66 (3%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	8/57 (14%)
		PLN03142	2029..>2606	CDD:215601	230/643 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarca2	XP_073805988.1	None