Protein Alignment kis and Smarca1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001258119.1
• Gene: Smarca1 / 317575
• RGDID: 1561046
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 1095
• Identity: 337/1095 - (30%)
• Similarity: 514/1095 - (46%)
• Gaps: 230/1095 - (21%)

  Fly  1791 EPETVLEKMEV---DEKA-----NDDQSAVS--KAEGSDEKSTDDSNPEEATTEKNKESLEIEGE 1845
            ||:|..|...|   |.:|     .|:|...|  |.||:...:|      ||||...|      ||
  Rat     2 EPDTATEAATVAASDARATIVVLEDEQPGPSTFKEEGAAAAAT------EATTATEK------GE 54

  Fly  1846 -KERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRV 1909
             ||::....:........|:|.:|:.:.|...:::.                      ||.||
  Rat    55 KKEKITSPFQLKLAAKTSKSEKEMDPEYEEKMVNIP----------------------LKADR-- 95

  Fly  1910 AAKIRRFQQKQSQQLNIF-----ENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKS 1969
             ||...|..||::....|     :.....|.|.      ::....|..|:      |..|:....
  Rat    96 -AKRFEFLLKQTELFAHFIQPSAQKSPTSPLNM------KLARPRVKKDD------KQSLISVGD 147

  Fly  1970 LPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQL 2034
              |.....|.|||                  .|..|:.|....:..:.|.:|.|..|..||.||:
  Rat   148 --YRHRRTEQEED------------------EELLSESRKTSNVCVRFEVSPSYVKGGPLRDYQI 192

  Fly  2035 EGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEG 2098
            .|||||...:.|..|.|||||||||||:|::..:..:..| ...||.:|:.|.||:.||..||:.
  Rat   193 RGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNFPGPHMVLVPKSTLHNWMNEFKR 257

  Fly  2099 WT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKE---PIKFNVLITTFEMIVTDYMDLKAFN 2159
            |. .:.|:.:.|.              |......:::   |.:::|.:|::||::.:....|.|:
  Rat   258 WVPSLRVICFVGD--------------KDVRAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFH 308

  Fly  2160 WRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFM 2224
            ||..|||||||:||...||.|.:|:....:|:||:|||||||:.||::|||||.|..|:|.::|.
  Rat   309 WRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFD 373

  Fly  2225 SEFGS---LRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQN 2286
            |.|.:   |..::.|.:|.|:|||.:|||:|.||||||.||:|..|.:.|:.:|:::|..||.::
  Rat   374 SWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKD 438

  Fly  2287 FSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGK 2351
            ...|........: .|:|.:|:|||||.||||.:|||.           ..|.:..::::.::||
  Rat   439 IDVLNSSGKMDKM-RLLNILMQLRKCCNHPYLFDGAEP-----------GPPYTTDEHIVSNSGK 491

  Fly  2352 MVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPG 2416
            ||.:||||.::|..|.||||||||.|.|||||||.::|.|.:.|:||:.....|:|||:.::.|.
  Rat   492 MVALDKLLARIKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFNAPN 556

  Fly  2417 SDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYE 2481
            |.:|:|:|.|:||||||||.:||.||:||||||||.||||..|.|||||:|.|:::||:..||.|
  Rat   557 SSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVE 621

  Fly  2482 REMFDKASMKLGLDKAVLQSMNTQGSK-DGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEE 2545
            ..:.::|.:||.||..|:|    ||.. |..:.:|:|:|:..:::.||.......::   :..:|
  Rat   622 ERIVERAEIKLRLDSIVIQ----QGRLIDQQSNKLAKEEMLQMIRHGATHVFACKES---ELTDE 679

  Fly  2546 DIDSILKR---RTQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTK-------WAKKVDID 2600
            ||.:||:|   :|..:....:|....|..:|.....:|....:..|:..|       |     |:
  Rat   680 DIVTILERGEKKTAEMNERMQKMGESSLRNFRMDLEQSLYKFEGEDYREKQKLGTVEW-----IE 739

  Fly  2601 PDACERDET--------EDLVLSEPR----------RRTQIKRYGHEDVMELNSEESSNENSDEE 2647
            |...||...        |.|.:|||:          ...|..::....:.||..:|.......
  Rat   740 PPKRERKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKT-- 802

  Fly  2648 GGIGLRSRRRKE-------KRDRAREKKGNDEYIPR---ERDALAALGLEEIQYGNWAKSECFKV 2702
              ||.:..|..|       :|:..::..|.:...|:   |:|.|...|     :.||.|.:..:.
  Rat   803 --IGYKVPRNPELPNPAIAQREEQKKIDGAEPLTPQESEEKDKLLTQG-----FTNWTKRDFNQF 860

  Fly  2703 EKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTF---IWD----- 2759
            .|....:|                 || |:::.||.:      ..|..|::..:   .|:
  Rat   861 IKANEKYG-----------------RD-DIDNVAREV------EGKSPEEVMEYSAVFWERCNEL 901

  Fly  2760 -----LITPTEDGEVQ-------------KISRDHSGLHNL-VPRGRNGGKSNKE 2795
                 ::...|.||.:             ||:|..:..|.| :..|.:.||:..|
  Rat   902 QDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTE 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	36/142 (25%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	11/66 (17%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	9/57 (16%)
		PLN03142	2029..>2606	CDD:215601	235/595 (39%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	314/1021 (31%)