Protein Alignment kis and Chd1l

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_063137972.1
• Gene: Chd1l / 310707
• RGDID: 1311935
• Length: 1070
• Species: Rattus norvegicus
• Alignment Length: 1061
• Identity: 191/1061 - (18%)
• Similarity: 333/1061 - (31%)
• Gaps: 398/1061 - (37%)

  Fly  1839 SLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCE-WRTEEEL 1902
            ||.|.|....:|....:....|:           :|.|..::|..::.::..||..: |:|..:
  Rat    14 SLNINGLNSLIKRHRLTNWIRNE-----------DPAFCCLQETHLRDKDRHYLRVKGWKTTFQ- 66

  Fly  1903 LKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPF-------NQDFTEVDRVLDMSVHTDETSGET- 1959
            ..|.::.|........|.:.||.:.:..::..|       :||...:     ::::...|...|
  Rat    67 ANGQKKQAGVAILISNKINFQLKVIKKDKEGHFIFIKGKIHQDELSI-----LNIYAPNTRAPTY 126

  Fly  1960 TKHYLVKWKS---------------LPYEDCTW--ELEEDVDN--------DKIEQYLRFNKIPQ 1999
            .|..|:|.|:               |...|.:|  :|..|||.        |.::.|..|  .|:
  Rat   127 VKETLLKLKTHIAPHTIIVGDFNTPLSSMDRSWKQKLNRDVDRLREVMSQMDLMDIYRTF--YPK 189

  Fly  2000 RSEWKSKKRPHPELWKKL-----EKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLG 2059
            ...:.....|| ..:.|:     :||               |||  ::.......|:|:|..||.
  Rat   190 AKGYTFFSAPH-GTFSKIDHIIGQKT---------------GLN--RYRKIEIIPCLLSDHQGLK 236

  Fly  2060 KTIQSLTFVHSVYEYGIRGPF----LVIAPL-STIPNWQ--REFEG------WTDMNVVVYHG-- 2109
            ....:.....|.|.:.:....    ||...: ..|.|:.  .|.||      |..|..|: .|
  Rat   237 LVFNNNQGRMSTYTWKLNNALLNDNLVKEEIKKEIKNFLEFNENEGTTYPNLWDTMKAVL-RGKL 300

  Fly  2110 ---SVTSKQMIQDY----EYYYKTESGKVLKEP--------IKFNVLITTFEMIVTDYMDLKAFN 2159
               |...|:.::.|    ..:.|....|....|        ||....|...|...|
  Rat   301 IALSACRKKQVRAYVSSLTAHLKALEQKEANTPRRSRRQEIIKLRAEINQVETKRT--------- 356

  Fly  2160 WRLCVIDEAHRLKN----RNCKLLEGLRQLNLEHRVLLSGTPLQN-------NISELFSLLNFLE 2213
                 |:..:|.|:    :..|:.:.|.:|...||..:....::|       :..|:..::....
  Rat   357 -----IERINRTKSWFFEKINKIDKPLARLTRGHRECIQINKIRNEKGDITTDSEEIQKIIRSYY 416

  Fly  2214 PSQFSSQEEFMSEFGSL--------RTEEEVNKL---------QALLKPM--------------- 2246
            .:.:|::.|.:.|..:.        ..:|::|:|         :|::|.:
  Rat   417 KNLYSTKLENLQEMDNFLDRYQVPKLNQEQINQLNNPITPKGIEAVIKGLPTKKSPGPDGFSAEF 481

  Fly  2247 ----------MLRRL--KDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANI 2299
                      :|.:|  |.:.:.||   ..|..|..:|.|.|.:.....::||..:......|.|
  Rat   482 YQTFIEDLIPILSKLFHKIETDGSL---PNTFYEATITLIPKPHKDTTKKENFRPISLMNIDAKI 543

  Fly  2300 PN--LMNTMMELRKCCIH----------------------------------------------- 2315
            .|  |.|.:.|..|..||
  Rat   544 LNEILANRIQEHIKTIIHHDQVGFIPGMQGWFNIRKTINVIHYIKKLKEQNHMIISLDAEKAFDK 608

  Fly  2316 -----------------PYL---------------LNGAE-EQIQYDFKSQHGEDPESYYKNLIL 2347
                             |||               |||.: |.|.....::.|.....|..|::|
  Rat   609 IQHPFMIKVLERIGIQGPYLNIVKAIYSKPVANIKLNGEKLEAIPLKSGTREGCPLSPYLFNIVL 673

  Fly  2348 SAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQ--EAID 2410
            .    ||...:..:.:..|::  |..:.|:.....:|.:||...|        :.:.|:  :.|:
  Rat   674 E----VLARAIRQQKEVKGNQ--IGKEEVKISLFADDMIVYLSDP--------KSSTRELLKLIN 724

  Fly  2411 RYSKP-----GSDRFVFLLCTKAGG--------------------LGINLTAADTVIIYDSDWNP 2450
            .:||.     .|::.|..|.||...                    ||:.|| .....:|:.::..
  Rat   725 NFSKVAGYKINSNKSVAFLYTKEKQAEKEIRETTPFIIDPNNIKYLGVTLT-KQVKDLYNKNFKT 788

  Fly  2451 -QNDLQAQAR------CHRIGQRKMVK-------IY------------------RLLCRNTYERE 2483
             :.:::...|      |..||:..:||       ||                  |.:|:..:..:
  Rat   789 LKKEIEEDLRRWKDLPCSWIGRINIVKMAILPKAIYSFNAIPIKIPIQFFKELDRTICKFIWNNK 853

  Fly  2484 MFDKASMKLGLDKAVLQSMNTQGS----------------------KDGNNKQLSKKEIED-LLK 2525
                   |..:.||:|....|.|.                      :|....|.::  ||| .:.
  Rat   854 -------KPSIAKAILNDKRTSGGITIPELKQYYRAIVIKTAWYWYRDRQIDQWNR--IEDPEMN 909

  Fly  2526 KGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSK---ASFAASGNRSDITIDDP 2587
            ...||.::.|..|.                   ||:.:|.|.|||   .::.::..|..|   ||
  Rat   910 PHTYGHLIFDKGAK-------------------TMKWKKDSIFSKWCWFNWRSTCRRMQI---DP 952

  Fly  2588 ------DFWTKWAKKVDIDPD 2602
                  ...:||.|.:.|.||
  Rat   953 CLSPCTKLKSKWIKDLHIKPD 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	16/84 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	10/67 (15%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	17/83 (20%)
		PLN03142	2029..>2606	CDD:215601	148/832 (18%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd1l	XP_063137972.1	None