Protein Alignment kis and Smarca5

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001424549.1
• Gene: Smarca5 / 307766
• RGDID: 1308832
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 983
• Identity: 321/983 - (32%)
• Similarity: 468/983 - (47%)
• Gaps: 216/983 - (21%)

  Fly  1940 TEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYL-----RFNKIPQ 1999
            ||::.|.|     |.:.|        |.|.:...|.|:|.:...|.....:||     .|....|
  Rat    55 TEMEEVFD-----DGSPG--------KQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQ 106

  Fly  2000 RSEWKSKKRP------HPELWK-------------------------------------KLEKTP 2021
            .:..|:...|      .|.:.|                                     :.|.:|
  Rat   107 PAAQKTPTSPLKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSP 171

  Fly  2022 VYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY-GIRGPFLVIAP 2085
            .|.....||.||:.|||||...:.|..|.|||||||||||:|:::.:..:..| .|.||.:|:.|
  Rat   172 SYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVP 236

  Fly  2086 LSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKE---PIKFNVLITTFEM 2147
            .||:.||..||:.|..        ::.|..:|.|     |.:....:::   |.:::|.:|::||
  Rat   237 KSTLHNWMSEFKRWVP--------TLRSVCLIGD-----KEQRAAFVRDVLLPGEWDVCVTSYEM 288

  Fly  2148 IVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFL 2212
            ::.:....|.||||..|||||||:||...||.|.:|:....:|:||:|||||||:.||:||||||
  Rat   289 LIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFL 353

  Fly  2213 EPSQFSSQEEFMSEFGS---LRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNI 2274
            .|..|:|.::|.|.|.:   |..::.|.:|..:|:|.:|||:|.||||||.||:|..|.|.|:.:
  Rat   354 LPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKM 418

  Fly  2275 QKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPE 2339
            |:::|..||.::...|........: .|:|.:|:|||||.||||.:|||.           ..|.
  Rat   419 QREWYTRILMKDIDILNSAGKMDKM-RLLNILMQLRKCCNHPYLFDGAEP-----------GPPY 471

  Fly  2340 SYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNL 2404
            :...:|:.::||||::||||||||..|.||||||||.|.|||||||.::|.|.:.|:||:...:.
  Rat   472 TTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDE 536

  Fly  2405 RQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMV 2469
            ||::|:.|::|.|.:|||:|.|:||||||||..||.||:||||||||.||||..|.|||||.|.|
  Rat   537 RQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTV 601

  Fly  2470 KIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGS-KDGNNKQLSKKEIEDLLKKGAYGAVM 2533
            :::|.:..||.|..:.::|.|||.||..|:|    ||. .|.|..::.|.|:..:::.||.....
  Rat   602 RVFRFITDNTVEERIVERAEMKLRLDSIVIQ----QGRLVDQNLNKIGKDEMLQMIRHGATHVFA 662

  Fly  2534 DDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKAS---FAASGNRSDITIDDPDF------ 2589
            ..::   :..:||||.||:|..:.....:||.|...::|   |......|....:..|:
  Rat   663 SKES---EITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKI 724

  Fly  2590 -WTKWAKKVDIDPDACERDET--------EDLVLSEPRR----------RTQIKRYGHEDVMEL- 2634
             :|:|     |:|...||...        |.|.:|||:.          ..|..::....:.||
  Rat   725 AFTEW-----IEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELL 784

  Fly  2635 ----------------------NSEESSNENS---DEEGGIGLRSRRRKE-----------KRD- 2662
                                  |:.::..|..   ||.|.:.......||           |||
  Rat   785 EKEILYYRKTIGYKVPRSPDLPNAAQAQKEEQLKIDEAGPLNDEELEEKEKLLTQGFTNWNKRDF 849

  Fly  2663 ----RAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQF 2723
                :|.||.|.|:.....|:.......|.|:|     |..|          |.|.:||
  Rat   850 NQFIKANEKWGRDDIENIAREVEGKTPEEVIEY-----SAVF----------WERCNEL------ 893

  Fly  2724 KRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNL-VPRGR 2787
                     :|..:|:    .|:.:|:.:|:..|  .|....|   .||.|..:..|.| :..|.
  Rat   894 ---------QDIEKIM----AQIERGEARIQRRI--SIKKALD---TKIGRYKAPFHQLRISYGT 940

  Fly  2788 NGGKSNKE 2795
            |.||:..|
  Rat   941 NKGKNYTE 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	14/59 (24%)
		PLN03142	2029..>2606	CDD:215601	245/594 (41%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Smarca5	NP_001424549.1	None