Protein Alignment kis and HELLS

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Alignment Length: 941
• Identity: 280/941 - (29%)
• Similarity: 430/941 - (45%)
• Gaps: 254/941 - (26%)

  Fly  1760 EEQSETVKTEENSKAIEE-----DKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSD 1819
            |||.|....|...|.:|:     |:.||.:   ..:..:.:|||..:..|     ..::|.|
Human    34 EEQLEAAGLERERKMLEKARMSWDRESTEI---RYRRLQHLLEKSNIYSK-----FLLTKME--- 87

  Fly  1820 EKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFV 1884
                    .::...:|.||.||.:.|..:||:|:.|:....::........:.:.
Human    88 --------QQQLEEQKKKEKLERKKESLKVKKGKNSIDASEEKPVMRKKRGREDE---------- 134

  Fly  1885 KYRNFSYLHCEWRTEEELLKGDRRVAAKIRR-FQQKQSQQLNIFENIEDEPFNQDFTEV--DRVL 1946
                 ||...|..::||:|.    ||.|.:: .:.:.|...|:.  :||...|:|...:  ||:
Human   135 -----SYNISEVMSKEEILS----VAKKNKKENEDENSSSTNLC--VEDLQKNKDSNSIIKDRL- 187

  Fly  1947 DMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHP 2011
                  .||..:.||.:.                     |.:.              |...:|.|
Human   188 ------SETVRQNTKFFF---------------------DPVR--------------KCNGQPVP 211

  Fly  2012 ELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGI 2076
                  .:.|.:..|..:|.||:||:.||:..|.|..|.|||||||||||:|.:..:..:.:.|:
Human   212 ------FQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGV 270

  Fly  2077 RGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNV 2140
            .|||||..||||:|||..||:.:| |:..::|||:...:|.:....|..|   |.:...|    |
Human   271 PGPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRK---GTLQIHP----V 328

  Fly  2141 LITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISEL 2205
            :||:||:.:.|...|:...|:..::||.||:||..|:|:..|::.|.::::||:|||||||:|||
Human   329 VITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSEL 393

  Fly  2206 FSLLNFLEPSQFSSQEEFMSEF----------GSLRTEEEVNKLQAL------------------ 2242
            :||||||.|..|...:.|.|.|          ..:..|.|.|.|..|
Human   394 WSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQERIPRMYVSEFTDEGF 458

  Fly  2243 -------------------------------LKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQK 2276
                                           |.|.:|||||.||...:.||.|.::...|:..|:
Human   459 FEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQE 523

  Fly  2277 KYYRGILEQ------------------------------NFSFL--------------------K 2291
            .:|..|:.:                              |:|.:                    :
Human   524 IFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVDRE 588

  Fly  2292 KGTTSANIP-------NLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSA 2349
            :.....|||       .|.|.||.|||||.||||:....:.:..:||..         :.|:.::
Human   589 RAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKID---------EELVTNS 644

  Fly  2350 GKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSK 2414
            ||.:::|::||:||..||:||:||||...||||.||...|.:.|.|:||.:..:.|::.:..::
Human   645 GKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFN- 708

  Fly  2415 PGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNT 2479
            ...:.|:||:.|:||||||||||||||||||||||||:|||||.|||||||.|.|.:|||:..||
Human   709 TDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANT 773

  Fly  2480 YEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSK-----KEIEDLLK--------KGAYGA 2531
            .::::.::|:.|..|:|.::...:.:|.:.|.|  |||     ||:.:|||        ||:...
Human   774 IDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLN--LSKNFLDPKELMELLKSRDYEREIKGSREK 836

  Fly  2532 VMDDDNAGDKFCEEDIDSILKRRTQVITMES 2562
            |:.|         :|::.:|.|...:..|.:
Human   837 VISD---------KDLELLLDRSDLIDQMNA 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	36/168 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	11/67 (16%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	8/59 (14%)
		PLN03142	2029..>2606	CDD:215601	227/664 (34%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
HELLS	NP_001275996.1	DEXHc_HELLS_SMARCA6	220..499	CDD:350767	99/285 (35%)
		PLN03142	221..>869	CDD:215601	227/666 (34%)