Protein Alignment kis and Chd3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_038943541.1
• Gene: Chd3 / 303241
• RGDID: 1311923
• Length: 2120
• Species: Rattus norvegicus
• Alignment Length: 2474
• Identity: 622/2474 - (25%)
• Similarity: 904/2474 - (36%)
• Gaps: 808/2474 - (32%)

  Fly  1276 EYSEGMGD-LSQDVHSANELDTSTD---------GSGKKKKPRKPRT-----PKDPNKPPRDRTP 1325
            |..|..|| ..::|.:|:|.|...|         |..:.:....|.:     |..|..||....|
  Rat    22 EEEEEEGDEEEEEVEAADEDDEEEDEEGVLGRGPGHDRGRDRHSPPSCHLFPPPPPPPPPLPPPP 86

  Fly  1326 KAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAE 1390
                |.|.:|.....:...||||....|::|                 :|||
  Rat    87 ----PPDKDDIRLLPSALGVKKRKRGPKKQK-----------------ENKP------------- 117

  Fly  1391 TTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTA 1455
                     |:            ||...:.:.|.|.|.|                  ||..|..:
  Rat   118 ---------GK------------PRKRKKLDSEEEFGSE------------------RDEYREKS 143

  Fly  1456 RSRRNANSEEG-GSARKNRGSLSAKALK--KRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDS 1517
            .|   ..||.| |..||.|.....|..|  |||.||    |.||....::
  Rat   144 ES---GGSEYGTGPGRKRRRKHREKREKKTKRRKRG----EGDGGHKQVE--------------- 186

  Fly  1518 NKRRSSRNTQRKKYIDDVMLRFSDDENSLLV--------ASPVKKDKKPSANASNSNAGSDVEKT 1574
              ::||........::||...||:::...|.        ..|:...|.|..
  Rat   187 --QKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI-------------- 235

  Fly  1575 EPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINT 1639
             |.|........:..|..:|.|...|:...|:::.:|.|....|:|. |.::|....|:
  Rat   236 -PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSA-AVSSATPIAPS------ 292

  Fly  1640 GDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEG------------- 1691
                                   ..|....|.|..:.:...:..|.|.:.:|
  Rat   293 -----------------------GPPPALPPPPAPEIQPPPIRRAKTKEGKGPGHKRRGKSARAP 334

  Fly  1692 DEKFKTEGES------KKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEV 1750
            |.:.|..|:.      |..|......|..|...:.|...|.|.::|        |.|...|....
  Rat   335 DGRKKLRGKKMAPLKIKLGLLGGRRRKAGSCVFQGDEGPEPEAEES--------DLDSGSVHSAS 391

  Fly  1751 GKSD---------------KESKPEEQS-----ETVKTEENSKAIEED---------KSSTVLTA 1786
            |:.|               |:.|.||.:     .||..||.....|.|         :...::..
  Rat   392 GRPDGPVRAKKLKRGRPGRKKKKGEEVTMFLGCPTVTGEEEVDGYETDHQDYCEVCQQGGEIILC 456

  Fly  1787 DHA--------------KEPE-----TVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEAT 1832
            |..              :.||     ...||..|..:|.:::....:.....||..:|.:.|...
  Rat   457 DTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEDYEEEGEEGEKEEEDDHMEYCR 521

  Fly  1833 TEKNKESL--------------------EI-EGE-----------KERVKE------GEESVKKE 1859
            ..|:...|                    :| .||           |.||::      ||..|...
  Rat   522 VCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVP 586

  Fly  1860 NDEKTEADMENKPEPVF--IDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQ 1922
            ..::.:.|.:..|..|.  ....|:|||:...||.||.|..|.:|   :.......|.:|:|
  Rat   587 APQQADGDPDAPPPRVLQGRSEREFFVKWVGLSYWHCSWAKELQL---EIFHLVMYRNYQRK--- 645

  Fly  1923 QLNIFENIEDEPFNQDF--------TEVDRVLD-------------------MSVH---TDETSG 1957
                  |..|||...|:        ::..:|.|                   |:||   ......
  Rat   646 ------NDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSMDK 704

  Fly  1958 ETTKHYLVKWKSLPYEDCTWELEE----DVDNDKIEQYLRFNKI------PQRSEWKSKKR---- 2008
            :...|||||||.|||:..|||.:|    :.|:.| :.|.|..::      .|..::|.||:
  Rat   705 KGNYHYLVKWKDLPYDQSTWEEDEMNIPEYDDHK-QSYWRHRELIMGEDPAQPRKYKKKKKEIQG 768

  Fly  2009 ------PHPELWKKLEKTP--VYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSL 2065
                  |..:...|.|..|  :...|.:|..|||||||||:|||....:.|||||||||||||::
  Rat   769 DGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTI 833

  Fly  2066 TFVHSVYEYG-IRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTES 2128
            .|::|:|:.| .:|||||.||||||.||:|||:.|. ...||.|.|...|:.:|::.|:.::..:
  Rat   834 VFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNA 898

  Fly  2129 GKVLKE--------PIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQL 2185
            .|..|:        .:||:||:|::|:|..|...|.:..|...|:||||||||...|....|...
  Rat   899 IKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGY 963

  Fly  2186 NLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRR 2250
            .::|::||:|||||||:.|||.|||||.|.:|::.|.|:.||..:..|:::.||..||.|.||||
  Rat   964 KIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRR 1028

  Fly  2251 LKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFL-KKGTTSANIPNLMNTMMELRKCCI 2314
            ||.||.|::..|.|.|:.|||:.:|||||:.||.:||..| .:|  ..|..:|:|.||:|:|||.
  Rat  1029 LKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRG--GGNQVSLLNIMMDLKKCCN 1091

  Fly  2315 HPYLLNGAEEQIQYDFKSQHGEDPESYYKN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVR 2377
            ||||...|        ..:..:.|...|:.  ||.|:||::|:.|:|.|||..||||||||||.:
  Rat  1092 HPYLFPVA--------AMESPKLPSGAYEGGALIKSSGKLLLLQKMLRKLKEQGHRVLIFSQMTK 1148

  Fly  2378 CLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVI 2442
            .||:|||:|.|..|.:|||||.|.|.||||||||::.||:.:|.|||.|:||||||||..|||||
  Rat  1149 MLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVI 1213

  Fly  2443 IYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGS 2507
            |:||||||.||:||.:|.|||||...|.|||.:.|.:.|..:...|..|:.|...|::.  ..||
  Rat  1214 IFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRP--GLGS 1276

  Fly  2508 KDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDK---------FCEEDIDSILKRR------TQV 2557
            |.|:   :||:|::|:||.|. ..:..|:|.|:.         :..|.|..:|.|.      |.|
  Rat  1277 KAGS---MSKQELDDILKFGT-EELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATDDTDV 1337

  Fly  2558 ITMESEKGSTFSKASFAASGNRSDITID-------------DPDFWTKWAKKVDIDPDACERDET 2609
            ..| :|..|:|..|.:..   |.:..|:             |||:|.|..:.       ....:.
  Rat  1338 QNM-NEYLSSFKVAQYVV---REEDKIEEIEREIIKQEENVDPDYWEKLLRH-------HYEQQQ 1391

  Fly  2610 EDLVLSEPRRRTQIKRYGHEDVMELNSE---------ESSNENSDE--EGGIGLRSRRRKEKRDR 2663
            |||..:..:.:...|:..:.|..:.:.:         |..:|:.||  ||       ||:.||..
  Rat  1392 EDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEG-------RRQSKRQL 1449

  Fly  2664 AREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWR 2728
            ..||   |:.:|   ..||.:|      ||                        :|:..|....|
  Rat  1450 RNEK---DKPLP---PLLARVG------GN------------------------IEVLGFNTRQR 1478

  Fly  2729 DVDVEDCARIILLYCLQVYKGDEKIKTFI-----WDLITPTEDG-EVQKISRDHSGLHNLVPRGR 2787
                                     |.|:     |.:  |.:|. ..|.:.||..
  Rat  1479 -------------------------KAFLNAVMRWGM--PPQDAFTTQWLVRDLR---------- 1506

  Fly  2788 NGGKSNKESTGVST------PAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSI 2846
              ||:.||.....:      ..||:                  |||
  Rat  1507 --GKTEKEFKAYVSLFMRHLCEPGA------------------DGS------------------- 1532

  Fly  2847 HDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELP 2911
                          :.:.:|..::.|.|  .:||.|:.::..::.:| .:| :.|.....:.||
  Rat  1533 --------------ETFADGVPREGLSR--QQVLTRIGVMSLVKKKV-QEF-EHINGRWSMPEL- 1578

  Fly  2912 IRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSL 2976
             .|.|:.|...||                          ||.      :.........:.:.|:.
  Rat  1579 -MPDPSADSKRSS--------------------------RAS------SPTKTSPTTPEASTTNS 1610

  Fly  2977 PINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDK 3041
            |.....|.....:    ..||..|..:.|.|     :|.:     |:|..|.|.        .:|
  Rat  1611 PCTSKPATPAPSE----KGDGVRTLLEKDDT-----ENPE-----EKPEKSSKV--------GEK 1653

  Fly  3042 TESENDATTVSESSYKSEVLPGKGSDLD--VSVAQQDALSATPELANTSDPKMN-KNDAQVSASV 3103
            .|:|.|:.:.:         |..|..|:  ..:.:.||    |.:....:|:.. :.|.:.|||
  Rat  1654 METEIDSPSPA---------PSLGERLEHRKILLEDDA----PGVPGEIEPEPGYRGDREKSAS- 1704

  Fly  3104 SCDPADSSSPEAAGK---------AQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKK 3159
              :|    :|...|:         .:.|..:|||.|: ..|..|.|.|....... |.|....::
  Rat  1705 --EP----TPGERGEEKPLDGQEHRERTEGETGDLGK-RAEDVKADRELRLGPPR-DEPRPNGRR 1761

  Fly  3160 DSAA------IARAEGDKTESCT---NNATTNISTTTTT-----------------------TTI 3192
            :...      ...|:|..||..|   |.....||:....                       ..|
  Rat  1762 EEKVEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDI 1826

  Fly  3193 TNTT--TTTNNPSSKAANSNNTTDHANS---------------------NSHLGLDEE------- 3227
            .|..  ...|.|....||..|..:..|.                     .::|.|.:|
  Rat  1827 QNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMA 1891

  Fly  3228 --------------------ESVAGSYPPTV------------------AAVEDATTMWPSMQDL 3254
                                ||:||:.|...                  ||.|.|..:
  Rat  1892 LHARFAEAECLAESHQHLSKESLAGNKPANAVLHKGKGRGGPARGRAHNAASEPAGGV------- 1949

  Fly  3255 NTRLRRVITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSG----- 3314
                          .::.|.:....|  ...|.:||..|.|:....|..|...|.|.|:.
  Rat  1950 --------------AERHEGRCDPPA--SHAVPNTPHRSPPSDVRAQHPQPTGQQGHGASPHTGL 1998

  Fly  3315 -------GSGIGSSAQ---HDASGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGGAG 3369
                   .||:..|.|   ....||..:.|..........:.....||||....|:|    ||.|
  Rat  1999 SPGSLRHTSGVRGSLQRRTRRGPGRRRRQLQPDASRVLHHSHHQRPSSAGEEREGNG----GGVG 2059

  Fly  3370 VMPA 3373
            |..|
  Rat  2060 VRRA 2063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	43/183 (23%)
		PTZ00121	<1419..1923	CDD:173412	120/621 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	18/74 (24%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	24/91 (26%)
		PLN03142	2029..>2606	CDD:215601	272/617 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd3	XP_038943541.1	CHDNT	203..256	CDD:462357	10/67 (15%)
		TNG2	<384..488	CDD:227367	17/103 (17%)
		PHD1_CHD_II	443..485	CDD:277006	3/41 (7%)
		PHD2_CHD_II	519..561	CDD:277007	5/41 (12%)
		CD1_tandem_CHD3-4_like	566..644	CDD:349314	21/80 (26%)
		CD2_tandem_CHD3-4_like	689..743	CDD:349309	20/54 (37%)
		PLN03142	780..>1334	CDD:215601	262/569 (46%)
		DEXHc_CHD3	797..1028	CDD:350813	109/230 (47%)
		DUF1087	<1375..1418	CDD:461922	10/49 (20%)
		CHDII_SANT-like	1439..1578	CDD:461920	44/275 (16%)
		PHA03169	<1570..>1761	CDD:223003	51/268 (19%)
		CHDCT2	1800..1926	CDD:462358	16/125 (13%)