Protein Alignment kis and Ttf2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001099924.2
• Gene: Ttf2 / 295324
• RGDID: 1309145
• Length: 1142
• Species: Rattus norvegicus
• Alignment Length: 1089
• Identity: 222/1089 - (20%)
• Similarity: 388/1089 - (35%)
• Gaps: 334/1089 - (30%)

  Fly  1658 RELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDS 1722
            ||.:||:.||:.|:.|...||....:....:..|.     :||.::     |:||....
  Rat   159 REQLLDQKKEQKPKSKCRMEKDPSSDLVVTRQSGG-----DGEEQE-----EKTKFRPK------ 207

  Fly  1723 KEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTAD 1787
                    :|:::|....:...||.....|..:.|:.|.|....|.|    |:.|.::..:|.:.
  Rat   208 --------TKETEEMTSKQGHGEVLQGTSKVPQISESESQEIPNKPE----ALSEKETHLLLQSI 260

  Fly  1788 HAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGE------K 1846
            ..:.||:.::|        :......:.:..|:...|..:.:.:.|..::.||:...:      |
  Rat   261 PGQNPESKVQK--------EGHLIREQLKNGDKTGADAHSAQASQTGLSQGSLQGPSKTWRPTPK 317

  Fly  1847 ERVKEG--EESVKKENDEKTEADMENKP-EPVFIDVEEYFVKYRNFSYLHCEWRTEEELL----- 1903
            .||..|  ..||........:::.:.:| .|:..|:.  ....:..|..|.:...:.:..
  Rat   318 ARVAPGVCSGSVHHATSSSDDSEDDGRPGSPLLFDLT--IDSQKKGSLQHSDQSVQRQTAAASGV 380

  Fly  1904 --KGDRR--------------------VAAKIRRFQQKQSQQLNIFENIED-------------- 1932
              ||:..                    .|..|:....|..:.|...:.:||
  Rat   381 SKKGESSDLAAQRANLTTQLKQKKGTLAAVNIQALPDKGEKLLKQIQALEDALNALALSPEQGTR 445

  Fly  1933 ------EPFNQDFTEVDRV---------------------LDMSVHTDET--------SGETTKH 1962
                  ||.....||....                     |.:.....||        .|.|.:|
  Rat   446 ENCSSQEPEQSKVTETAAAGPLHLVPPQPLPRPHIQPAASLGLKASRQETPEGASQCSGGHTNEH 510

  Fly  1963 YLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLE----KTPVY 2023
            .|.                                   :.||.......||.:.||    ||.|.
  Rat   511 RLY-----------------------------------NVWKITSEAIDELHRSLESCPGKTAVA 540

  Fly  2024 KGGNSLRP----YQLEGLNWLKFSWYNT---HNCILADEMGLGKTIQSLTFV------------- 2068
            :....|:.    :|.:.|.||  .|..:   ...||||:||||||:..:..:
  Rat   541 EDPAGLKVPLLLHQKQALAWL--LWRESQKPQGGILADDMGLGKTLTMIALILTKKNQQKSKEKD 603

  Fly  2069 ------------HSVY-EYGIRGPFLVIAPLSTIPNWQREFEGWTDMN---VVVYHGSVTSKQMI 2117
                        .||: ..|.    |::.|.|.|.:|:.|.|...:.|   :.:|||.
  Rat   604 RSLPVMWLSKNDSSVFTSTGT----LIVCPASLIHHWKNEIEKRVNSNKLRIYLYHGP------- 657

  Fly  2118 QDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLK--------------------AFNWRL 2162
                  .:.:..|||.   .::::|||:.::..:....|                    ...|..
  Rat   658 ------NRIQHAKVLS---TYDIVITTYSLLAKEIPTAKHEGEVPGAKLSVEGISAPLLQVVWAR 713

  Fly  2163 CVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF 2227
            .::||||.:||...:....:.:|..:.|..::|||:|||:.:::||:.||..|.|.....:.|:.
  Rat   714 IILDEAHNVKNPRVQTSIAVCKLQAQARWAVTGTPIQNNLLDMYSLMKFLRCSPFDEFSLWKSQV 778

  Fly  2228 --GSLRTEEEVNKLQALLKPMMLRRLKDDVE---KSLAP---KEETIIEVELTNIQKKYY----- 2279
              ||::..|   :|..|.|.::|||.||.::   |.|.|   :...:..::|:..::..|
  Rat   779 DNGSMKGGE---RLSILTKSLLLRRTKDQLDSTGKPLVPLPARSCQLHRLKLSEDERAVYDVFLA 840

  Fly  2280 --RGILEQNFSFLKK--------GTTSAN------------IP--------------NLMNTMME 2308
              |..|:   |:||:        |.:..|            :|              ::::.::.
  Rat   841 RSRSALQ---SYLKRQEGRGSHPGRSPENPFSRVAQEFGSGVPQCSTAADSRRPSTVHVLSQLLR 902

  Fly  2309 LRKCCIHPYLLNGA---------------EEQIQYDFKSQHGEDPESYYKNLILSAGKMVLID-- 2356
            ||:||.|..||...               |||:.....|:......|...:|..:..|:.|.|
  Rat   903 LRQCCCHLSLLKSVLDPKELESEGLVLSLEEQLSALTLSKVDVSEPSPTVSLNGTCFKVELFDDI 967

  Fly  2357 -------KLLPKLKA-----NGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAI 2409
                   .||.:|:|     ...:.:|.||....|.::..:|...:..:..|||.:....|.:.:
  Rat   968 RRSTKVSSLLAELEAIQKGPGSQKSVIVSQWTSMLQVVALHLRKNRLTYATIDGSVNPKQRMDLV 1032

  Fly  2410 DRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRL 2474
            :.::.....: |.|:...|||:|:|||..:.:.:.|..|||..:.||..|.:|:||.|.|.::|.
  Rat  1033 EAFNHSQGPQ-VMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQEKDVVMHRF 1096

  Fly  2475 LCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            :|..|.|.::......|..|.|.||         .|:...::|..:.||
  Rat  1097 VCEGTVEEKILQLQEKKKDLAKQVL---------SGSGGPVTKLTLADL 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	53/300 (18%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/96 (13%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	9/86 (10%)
		PLN03142	2029..>2606	CDD:215601	146/629 (23%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Ttf2	NP_001099924.2	zf-GRF	6..44	CDD:480736
		HepA	<536..1122	CDD:440319	145/623 (23%)
		DEXHc_TTF2	550..800	CDD:350830	65/274 (24%)