Protein Alignment kis and smarca5

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001075098.2
• Gene: smarca5 / 282615
• ZFINID: ZDB-GENE-021125-1
• Length: 1035
• Species: Danio rerio
• Alignment Length: 1192
• Identity: 350/1192 - (29%)
• Similarity: 526/1192 - (44%)
• Gaps: 328/1192 - (27%)

  Fly  1667 EKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDS 1731
            |.:.|.:::||.|:||.|              |.::.|.:::...:...:||:.:::..|.|
Zfish     5 ESSMEQQREEEPSQLDPA--------------GPAEDDTSENGHDEASDTAMDSEAQSSSPP--- 52

  Fly  1732 KKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVL 1796
                 ..|.||.:            ...||:.:|                     |.....|.:|
Zfish    53 -----SAKGKDLL------------GGYEEKVQT---------------------DRTNRFEYLL 79

  Fly  1797 EKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKEND 1861
            ::.||  .|:..|.|..|...|..|                           :|.|...:||  |
Zfish    80 KQTEV--FAHFIQPAAQKTPTSPLK---------------------------MKPGRPRIKK--D 113

  Fly  1862 EKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNI 1926
            ||                                   :..|..||.|    .||.:|::.::|
Zfish   114 EK-----------------------------------QNLLSAGDNR----HRRTEQEEDEEL-- 137

  Fly  1927 FENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQY 1991
                                 :|.::..||                 .||
Zfish   138 ---------------------LSENSKATS-----------------VCT--------------- 149

  Fly  1992 LRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEM 2056
                                    :.:.:|.|.....||.||:.|||||...:.|..|.||||||
Zfish   150 ------------------------RFDDSPSYVKTGKLRDYQVRGLNWLISLYENGINGILADEM 190

  Fly  2057 GLGKTIQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDY 2120
            |||||:|:::.:..:..| .|.||.:|:.|.||:.||..||:.|..        |:.:..:|.|.
Zfish   191 GLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLYNWMNEFKRWVP--------SLKAVCLIGDR 247

  Fly  2121 EYYYKTESGKVLKE---PIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGL 2182
            |     |....:::   |.:::|.:|::||::.:....|.||||..|||||||:||...||.|.:
Zfish   248 E-----ERTAFIRDTLLPGEWDVCVTSYEMLIIERAVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 307

  Fly  2183 RQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS---LRTEEEVNKLQALLK 2244
            |:....:|:||:|||||||:.||::|||||.|..|:|.|:|.:.|.:   |...:.|.:|..:|:
Zfish   308 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSEDFDAWFDTNNCLGDTKLVERLHTVLR 372

  Fly  2245 PMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMEL 2309
            |.:|||:|.||||||.||:|..|.|.|:.:|:::|..||.::...|........: .|:|.:|:|
Zfish   373 PFLLRRIKADVEKSLLPKKEIKIYVGLSKMQREWYTKILMKDIDILNSAGKMDKM-RLLNVLMQL 436

  Fly  2310 RKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQ 2374
            ||||.||||.:|||.           ..|.:...:|::::||||::||||||||..|.|||||||
Zfish   437 RKCCNHPYLFDGAEP-----------GPPYTTDLHLVVNSGKMVVLDKLLPKLKEQGSRVLIFSQ 490

  Fly  2375 MVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAAD 2439
            |.|.|||||||.::|.|.:.|:||:.....||.:|:.:::|.|.:|:|:|.|:||||||||..||
Zfish   491 MTRVLDILEDYCMWRNYGYCRLDGQTPHEERQISINAFNEPNSSKFLFMLSTRAGGLGINLATAD 555

  Fly  2440 TVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNT 2504
            .|||||||||||.||||..|.|||||:|.|:::|.:..||.|..:.::|.|||.||..|:|
Zfish   556 VVIIYDSDWNPQVDLQAMDRAHRIGQKKQVRVFRFITDNTVEERIVERAEMKLRLDSIVIQ---- 616

  Fly  2505 QGS-KDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITME-SEKGST 2567
            ||. .|.:..:|.|.|:..:::.||.......::   :..:||||.||:|..:. ||| .||.:.
Zfish   617 QGRLVDPSMNKLGKDEMLSIIRHGATHVFASKES---EITDEDIDGILERGERK-TMEMKEKMAN 677

  Fly  2568 FSKAS---FAASGNRSDITIDDPDFWTKWAKKVD---IDPDACERDET--------EDLVLSEPR 2618
            ..:.|   |......|....:..|:..|  |||.   |:|...||...        |.|.:|||:
Zfish   678 LGEGSLRNFTMDTENSVYNFEGEDYREK--KKVVTNWIEPPKRERKANYAVDAYFREALRVSEPK 740

  Fly  2619 R----------RTQIKRYGHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEY 2673
            .          ..|..::....:.||..:|.......    ||.:..|..:..:.|..:|.....
Zfish   741 APKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKT----IGYKVPRNPDLPNSAEMQKEEQAK 801

  Fly  2674 IPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRG---WRDVDVEDC 2735
            |    |....|..||::           .::.|||.|:..|:: .:..||.:.   |...|:|:.
Zfish   802 I----DEAEPLNEEELE-----------EKENLLSQGFTIWTK-RDFNQFIKANEKWGRDDIENI 850

  Fly  2736 ARIILLYCLQVYKGDEKIKTF---IWD----------LITPTEDGEVQ-------------KISR 2774
            ||.:      ..|..|::..:   .|:          ::...|.||.:             ||.|
Zfish   851 AREV------EGKTPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDSKIGR 909

  Fly  2775 DHSGLHNL-VPRGRNGGKSNKE 2795
            ..:..|.| :..|.|.||:..|
Zfish   910 YKAPFHQLRISYGTNKGKNYTE 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	45/255 (18%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/66 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	5/57 (9%)
		PLN03142	2029..>2606	CDD:215601	248/591 (42%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarca5	NP_001075098.2	PLN03142	4..1030	CDD:215601	350/1192 (29%)