Protein Alignment kis and Chd5

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_006538992.1
• Gene: Chd5 / 269610
• MGIID: 3036258
• Length: 1955
• Species: Mus musculus
• Alignment Length: 2309
• Identity: 600/2309 - (25%)
• Similarity: 894/2309 - (38%)
• Gaps: 703/2309 - (30%)

  Fly  1412 KIPR-GSNEDEKEAEAGDET-------VDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGS 1468
            ::|| .:.|.|.|.|..:|.       .|..|   .:|.|.|.::.:|...::|.:....::.||
Mouse    10 ELPRLFAEEMENEEEMSEEEDGGLEGFEDFFP---AEPVSLPKKKPKKLKESKSSKGKRKKKEGS 71

  Fly  1469 ---ARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKK 1530
               ...|...|..|:            ||:|.|.:      |:.....::...|.:..:..:|||
Mouse    72 NDEMSDNEEDLEEKS------------ESEGSDYS------PTKKKKKKLKEKKEKKEKKEKRKK 118

  Fly  1531 Y--------------------------IDDVMLRFSDDENSLLV--------ASPVKKDKKPSAN 1561
            .                          :|||...||:|:...|.        ..|:...|.|...
Mouse   119 RGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIP 183

  Fly  1562 ASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANA 1626
            .|         |.....||:.      .|..:|.|...||...|:::.:|..|    ..|.|...
Mouse   184 MS---------KMMTVLGAKW------REFSANNPFKGSSAAAAAAAVAAAVE----TVTIAPPL 229

  Fly  1627 AMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEG 1691
            |:|.:.              |...|.:|           |.|..|.|....:.:...|...|.:|
Mouse   230 AISPQQ--------------VPQTLPIR-----------KAKTKEGKGPGVRKKNKGAKDSKKKG 269

  Fly  1692 ------DEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDD------SKKSD-------ED 1737
                  ..||:..|.||:.         :.|:.|.|.:|:|:.|:      |.:|:       ::
Mouse   270 RGKRVAGLKFRFGGISKRK---------KGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKN 325

  Fly  1738 NKDKDKMEVDDEVG-KSDKESKPE---EQSETVKTEENSKAIEEDKSSTVLTADHAKEPE----- 1793
            .:.:.|..:||..| ::|.:...|   :..|.:..:...:|..    ...|..:..|.||
Mouse   326 KRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYH----LVCLDPELEKAPEGKWSC 386

  Fly  1794 TVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDS----------------------------NPEE 1830
            ...||..:..:..||..  .:.||..|:..||.                            || .
Mouse   387 PHCEKEGIQWEPKDDDE--EEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNP-P 448

  Fly  1831 ATTEKNKESL-------EIEGEKERVKE------------GEESVKKENDEKTEADMENKPEPVF 1876
            .....|.|.|       .::|:.:|:..            |....:.|........:|..||
Mouse   449 LPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPE--- 510

  Fly  1877 IDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPF------ 1935
               .|:|||:...||.||.|..|.:|   :.......|.:|:|....       |..||
Mouse   511 ---REFFVKWAGLSYWHCSWVKELQL---ELYHTVMYRNYQRKNDMD-------EPPPFDYGSGD 562

  Fly  1936 ---------NQD------------------FTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYE 1973
                     |:|                  :..|.|:|:   |:.:..|:.  |||:|||.|||:
Mouse   563 EDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILN---HSFDKKGDI--HYLIKWKDLPYD 622

  Fly  1974 DCTWELEE-DV---DNDKIEQYLRFN--------KIPQRSEWKSKK-----------RPHPELWK 2015
            .||||::| |:   ||.| :.|....        ::|:|...|.||           .|..:...
Mouse   623 QCTWEIDEIDIPYYDNLK-QAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTV 686

  Fly  2016 KLEKTPVY--KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IR 2077
            |.:|.|.|  ..|.:|.||||||||||:|||....:.|||||||||||:|::.|::|:|:.| .:
Mouse   687 KFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSK 751

  Fly  2078 GPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTES---GK----VLKE 2134
            ||:||.||||||.||:||||.|. |..||.|.|...|:.:|::.|:.::..:   ||    :.||
Mouse   752 GPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKE 816

  Fly  2135 -PIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPL 2198
             .|||:||:|::|:|..|...|.:..|...|:||||||||...|....|....:::::||:||||
Mouse   817 VQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPL 881

  Fly  2199 QNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKE 2263
            |||:.|||.|||||.|.:|::.|.|:.||..:..|:::.||..||.|.||||||.||.|::..|.
Mouse   882 QNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKT 946

  Fly  2264 ETIIEVELTNIQKKYYRGILEQNFSFL-KKGTTSANIPNLMNTMMELRKCCIHPYLL-------- 2319
            |.|:.|||:.:|||||:.||.:||..| .||  ..|..:|:|.||:|:|||.||||.
Mouse   947 ELIVRVELSQMQKKYYKFILTRNFEALNSKG--GGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAP 1009

  Fly  2320 ---NGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDI 2381
               ||:     ||..|            |:.|:||::|:.|:|.||:..||||||||||.:.||:
Mouse  1010 VLPNGS-----YDGSS------------LVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDL 1057

  Fly  2382 LEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDS 2446
            |||:|.|..|.:|||||.|.|.||||||||::.||:.:|.|||.|:||||||||..|||||||||
Mouse  1058 LEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDS 1122

  Fly  2447 DWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGN 2511
            ||||.||:||.:|.|||||.|.|.|||.:.|.:.|..:...|..|:.|...|::.  ..|||.|:
Mouse  1123 DWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRP--GLGSKSGS 1185

  Fly  2512 NKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKR----RTQVITMESEKGSTFS--- 2569
               ::|:|::|:||.|.           ::..::|::.::.:    .|.:..::|.||.:.:
Mouse  1186 ---MTKQELDDILKFGT-----------EELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGA 1236

  Fly  2570 --KASFAASGNRSD------ITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRY 2626
              |......|:..|      |..||...    :|.:|.:.||  .|:||
Mouse  1237 KKKHGSTPPGDNKDVEDSSVIHYDDAAI----SKLLDRNQDA--TDDTE---------------- 1279

  Fly  2627 GHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQY 2691
                :..:|...||.:.:                           :|:.||.|     |:||::
Mouse  1280 ----LQNMNEYLSSFKVA---------------------------QYVVREED-----GVEEVE- 1307

  Fly  2692 GNWAKSECFKVEKGLLSFGWGRWSELL-------------ELGQFKRGWRDVDVEDCARIILLYC 2743
                 .|..|.|:.:   ....|.:||             .||:.||..:.|:..|.::
Mouse  1308 -----REVIKQEENV---DPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQ------ 1358

  Fly  2744 LQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSAS 2808
                   |......|.........|....|.|........|.|::|.:.::...
Mouse  1359 -------EDQGACEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQL----------- 1405

  Fly  2809 GSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSI-------HDP--NHW------SKKEKY 2858
              .|....|.....|..|.:.:..|.||....|.:.:|       .|.  :||      .|.||.
Mouse  1406 --KSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKE 1468

  Fly  2859 ------------------DADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKD-N 2904
                              .|:.:.:|..::.|.|  ..||.|:.::..::.:     ||:.:. |
Mouse  1469 FRAYVSLFMRHLCEPGADGAETFADGVPREGLSR--QHVLTRIGVMSLVRKK-----VQEFEHVN 1526

  Fly  2905 TPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGD 2969
            ...|        |||.||..                ..|.:....:.:|||    |.|.|..|
Mouse  1527 GKYS--------TPDLVPEG----------------AEGKKPGEVISSDPN----TPVPASPA-- 1561

  Fly  2970 DLAVTSLPINEDDANSKHDDGDEVDDD-GTTTTKDSDSTKLTGGDNKDSL--------LDPERPS 3025
            .|....|.:.           |:::.. |.|..|:|...|     .|.||        ||.....
Mouse  1562 QLPPAPLGLT-----------DKMEAQLGYTDEKESGMQK-----PKKSLEIQTLPTALDRVEGE 1610

  Fly  3026 SSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDP 3090
            ...:||........::||....|....|...|.||||.|                        :|
Mouse  1611 DKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDK------------------------EP 1651

  Fly  3091 KMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKD--------------- 3140
            ..:|.:..:..|....|.|   |:...|..|...|.||..| |.|.:|:|
Mouse  1652 IPDKPELSLGHSGDFRPDD---PKTEEKEPGETQQNGDREE-DEEGKKEDKNGKFKFMFNIADGG 1712

  Fly  3141 ---------NEKETKESTGDAPAV----------------------EAKKDSAAIARAEGDKTES 3174
                     ||:....|:|....:                      :.:.|...:...|..|:|.
Mouse  1713 FTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEI 1777

  Fly  3175 CTNN-----------------ATTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNSHL 3222
            ...|                 ....|..........|.|...|:| :.|.|:........:.||.
Mouse  1778 HKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHP-AMALNARLAEVECLAESHQ 1841

  Fly  3223 GLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKEELKLQQKA---KLQA 3284
            .| .:||:||:.|                  .|..|.:|:.      :.|||....||   :|.:
Mouse  1842 HL-SKESLAGNKP------------------ANAVLHKVLN------QLEELLSDMKADVTRLPS 1881

  Fly  3285 LVSSTPPLSVPTTPTLQSMQMQLQSGSGS---GGSGIGSSAQHDASGRSLQALMQSQGASTSAAA 3346
            ::|..||::.....:.:|:..:|.:.:|.   .....|||..::
Mouse  1882 MLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSSQMYN--------------------- 1925

  Fly  3347 AAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADI 3380
                :|.|.:..|.|..|:.....||..|...||
Mouse  1926 ----NSFGPNFRGPGPGGIVNYNQMPLGPYVTDI 1955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	23/98 (23%)
		PTZ00121	<1419..1923	CDD:173412	122/622 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	17/78 (22%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	25/79 (32%)
		PLN03142	2029..>2606	CDD:215601	271/613 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd5	XP_006538992.1	CHDNT	148..203	CDD:462357	15/69 (22%)
		PHD1_CHD_II	347..389	CDD:277006	7/45 (16%)
		PHD2_CHD_II	420..462	CDD:277007	5/42 (12%)
		CD1_tandem_CHD3-4_like	467..546	CDD:349314	19/87 (22%)
		CD2_tandem_CHD3-4_like	591..644	CDD:349309	23/58 (40%)
		PLN03142	700..>1218	CDD:215601	257/552 (47%)
		DUF1087	1300..1353	CDD:461922	15/66 (23%)
		CHDII_SANT-like	1394..1534	CDD:461920	30/167 (18%)
		LGT	<1535..1687	CDD:469786	45/216 (21%)
		CHDCT2	1734..1879	CDD:462358	28/170 (16%)