Protein Alignment kis and hrp3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001342861.1
• Gene: hrp3 / 2543064
• PomBaseID: SPAC3G6.01
• Length: 1388
• Species: Schizosaccharomyces pombe
• Alignment Length: 1654
• Identity: 465/1654 - (28%)
• Similarity: 705/1654 - (42%)
• Gaps: 399/1654 - (24%)

  Fly  1649 LVLAMRMGKRELILDKPKEKAPEPKQD--EEKSELDEATTDKPEGDEKFKTE--GESKKDLTDSE 1709
            :.||:...|....||..:.:.|..||:  |..|....|:..|.:..|....|  |..:...|.|.
pombe     6 IALALSSSKAIEQLDHVQTETPNLKQEMSESPSNSGVASKRKLQSTEWLDPELYGLRRSGRTRSN 70

  Fly  1710 ETKLESSAMEVDSKEESEPDDSKKSDED----NKDKDKMEVDDEVGKSDKESKPEEQSETVKTEE 1770
            ..:.    ::.|.:|:..|...:|...:    ::.:...::|||             :|:|.:||
pombe    71 PGRY----VDTDDQEDVFPSKHRKGTRNGSSFSRHRTIRDLDDE-------------AESVTSEE 118

  Fly  1771 NSKAIEEDKSS---TVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEAT 1832
            :    |.|.||   |.......|:..|.::    ||.....::  ||....:|.:..:|..||..
pombe   119 S----ESDDSSYGGTPKKRSRQKKSNTYVQ----DEIRFSSRN--SKGVNYNEDAYFESFEEEEE 173

  Fly  1833 TEKNKESLEIEGEKE-----------RVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKY 1886
            .|..:.:.|:..|.|           |:.||.:......|                  .|:.:|:
pombe   174 EEMYEYATEVSEEPEDTRAIDVVLDHRLIEGHDGSTPSED------------------YEFLIKW 220

  Fly  1887 RNFSYLHCEWR--TEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFN------------- 1936
            .|||:|||.|.  ....:::|.::|...|:       |.:.:...|.::|..
pombe   221 VNFSHLHCTWEPYNNISMIRGSKKVDNHIK-------QVILLDREIREDPTTTREDIEAMDIEKE 278

  Fly  1937 ------QDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFN 1995
                  :::.:|||::...:::|     .:..||||||.|.|:.||||....::.....:...|.
pombe   279 RKRENYEEYKQVDRIVAKHLNSD-----GSVEYLVKWKQLLYDFCTWEASSIIEPIAATEIQAFQ 338

  Fly  1996 K------IPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILAD 2054
            :      .|.|.......||.   ::|||:.|.|..|..||.:||.|:||:.:.|:...|.||||
pombe   339 EREESALSPSRGTNYGNSRPK---YRKLEQQPSYITGGELRDFQLTGVNWMAYLWHKNENGILAD 400

  Fly  2055 EMGLGKTIQSLTFV----HSVYEYGIRGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSK 2114
            |||||||:|::.|:    ||:.::   |||||:.||||:|.||.....| :|||.:.|.|:.||:
pombe   401 EMGLGKTVQTVAFLSYLAHSLRQH---GPFLVVVPLSTVPAWQETLALWASDMNCISYLGNTTSR 462

  Fly  2115 QMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLL 2179
            |:|:|||:|...      .:.||||:|:||:|.::.|...|....|:...|||||||||....|.
pombe   463 QVIRDYEFYVDG------TQKIKFNLLLTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESSLY 521

  Fly  2180 EGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLK 2244
            |.|.|....:|:|::||||||||.||.:|::||.|.:|..:||...|......|..:..||..|:
pombe   522 EALSQFKNSNRLLITGTPLQNNIRELAALVDFLMPGKFEIREEINLEAPDEEQEAYIRSLQEHLQ 586

  Fly  2245 PMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMEL 2309
            |.:|||||.||||||..|.|.|:.|||:::|..:|:.||.:|:..|.:..:|.:..:|:|.::||
pombe   587 PYILRRLKKDVEKSLPSKSERILRVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVEL 651

  Fly  2310 RKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQ 2374
            :|...||||.:|.||.......||...|  ...|.||:::|||||:||||.:|:.:|||||||||
pombe   652 KKASNHPYLFDGVEESWMQKINSQGRRD--EVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQ 714

  Fly  2375 MVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAAD 2439
            |||.||||.|||..|.||.:|:||.:...:|:.:||.::.|.|..|||||.|:||||||||..||
pombe   715 MVRMLDILGDYLSLRGYPHQRLDGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTAD 779

  Fly  2440 TVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNT 2504
            ||||:|||||||.||||.||.|||||:..|.:||||.::|.|.::.::|..|:.|:.|::....|
pombe   780 TVIIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLLSKDTIEEDVLERARRKMILEYAIISLGVT 844

  Fly  2505 QGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITME-----SEK 2564
            ...|:..|.:.|.:|:..:||.||......::|. .|..:.::|.||:......|..     |..
pombe   845 DKQKNSKNDKFSAEELSAILKFGASNMFKAENNQ-KKLEDMNLDEILEHAEDHDTSNDVGGASMG 908

  Fly  2565 GSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHE 2629
            |..|.| .|..:..::|::.|            ||.| ..||::.|:    |.|.|.:.:....|
pombe   909 GEEFLK-QFEVTDYKADVSWD------------DIIP-LTEREKFEE----EDRLREEEEALKQE 955

  Fly  2630 DVMELNSEE------SSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEE 2688
              :||:|..      ||...|....|...|..:::..:|....:|           .:..|....
pombe   956 --IELSSRRGNRPYPSSAVESPSYSGTSERKSKKQMLKDEVLLEK-----------EIRLLYRAM 1007

  Fly  2689 IQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKI 2753
            |:||:...                |::::::       :.|:..:|.               ..|
pombe  1008 IRYGSLEH----------------RYNDIVK-------YADLTTQDA---------------HVI 1034

  Fly  2754 KTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPA 2818
            |....||:|.:... |....:|.|          |...:||.|
pombe  1035 KKIAADLVTASRKA-VSAAEKDLS----------NDQSNNKSS---------------------- 1066

  Fly  2819 HKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDA--DAYLEGAYKKHLGRHANKVLL 2881
              ..||..:.|....|||..:...:..:            |.  ||.....|...      ::.:
pombe  1067 --RKALLITFKGVKNINAETLVQRLNDL------------DILYDAMPTSGYSNF------QIPM 1111

  Fly  2882 RVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSW---WNPICCDKSLLVGTYKHG 2943
            .||.::                                    .|   |.| ..|..||.|..|||
pombe  1112 HVRSVH------------------------------------GWSCQWGP-REDSMLLSGICKHG 1139

  Fly  2944 CEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTK 3008
            ...:.::|.||.|                             |..|...::|     ||.:|::.
pombe  1140 FGAWLEIRDDPEL-----------------------------KMKDKIFLED-----TKQTDNSV 1170

  Fly  3009 LTGGDNKDS--------------LLDP--ERPSSSGKSSSENASGGNDKTESENDATTVSESSYK 3057
            ....:||:.              ||..  |...:.|..||. |...|.||:.:.......:|
pombe  1171 PKDKENKEKKVPSAVHLVRRGEYLLSALREHHQNFGIKSSP-AISTNGKTQPKKQTANRRQS--- 1231

  Fly  3058 SEVLPGKGSDLDVSVAQQ-DALSATPELA--------NTSDPKMNKNDAQVSASVSCDPADSSSP 3113
                 ||.   :|..||: ::.:.||..|        ::.|.|:.....:.|.|.:..|..|..
pombe  1232 -----GKP---NVKSAQKIESATRTPSPAISESRKKPSSKDTKIETPSREQSRSQTASPVKSEK- 1287

  Fly  3114 EAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPA----VEAKKDSAAIARAEGDK--T 3172
                          |.|.:.:.:|:|...||..     .|.    ...:|||:.:.|||..|  |
pombe  1288 --------------DDGNVSLNAEQKARCKELM-----YPVRKHMKRLRKDSSGLGRAELVKLLT 1333

  Fly  3173 ESCTNNATTNISTTTTTTTITNTTTTTNN 3201
            | |......:|..|...|......|...|
pombe  1334 E-CLTTIGKHIEKTVNDTPSEEKATVRKN 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	63/297 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	15/68 (22%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	16/57 (28%)
		PLN03142	2029..>2606	CDD:215601	255/586 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
hrp3	NP_001342861.1	CD1_tandem_CHD1_yeast_like	189..250	CDD:349312	15/78 (19%)
		CD2_tandem	286..339	CDD:349306	17/57 (30%)
		PLN03142	339..>895	CDD:215601	254/570 (45%)
		Cdh1_DBD_1	997..1081	CDD:408024	23/167 (14%)
		DUF4208	1300..1384	CDD:464035	18/68 (26%)