Protein Alignment kis and rrp2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_596602.1
• Gene: rrp2 / 2540464
• PomBaseID: SPBC23E6.02
• Length: 1040
• Species: Schizosaccharomyces pombe
• Alignment Length: 1133
• Identity: 236/1133 - (20%)
• Similarity: 418/1133 - (36%)
• Gaps: 360/1133 - (31%)

  Fly  1622 DAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELD--EA 1684
            |..|...:......|.::...|.::...:....|.:|...|:: |:........:..|.|:  |:
pombe    22 DKHNIGFNKNNTPDYSSSASSDQLLKNDINRHEMERRIAFLNR-KQALFNAFMHDSSSSLNTMES 85

  Fly  1685 TTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPD----------DSKKSDEDNK 1739
            ..:|..|  .|..: .|...|..:|| ||.|| :.|::.:.:..|          |....:....
pombe    86 NIEKVNG--LFPND-NSVIALKPNEE-KLNSS-LSVENNDSTYTDATLIAPKIGLDRPNINAITI 145

  Fly  1740 DKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEK 1804
            |.|...:.:|:..|..:..|.:          |.|:.|.|..::...|:|        .:.|.:.
pombe   146 DVDGHSLQNEISSSTDKLSPSQ----------SDALFEQKQDSLFWNDNA--------VIVVSDS 192

  Fly  1805 ANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADME 1869
            .:||.:..:|:         ..|..:....|.|.:||:              ...|.::.:.::.
pombe   193 ESDDNNVRTKS---------SLNDHDKVNMKEKRNLEL--------------AFMNSKRKKLELP 234

  Fly  1870 NKPE--------------PVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQ 1920
            :.|.              |.|    .:...|:.|:..|.  ..:::.|:|.......|....::.
pombe   235 SLPVLSTAGPSYTNSLALPPF----HHHNNYKMFNTTHT--LEDDKFLQGKGTSNNPISLSDEED 293

  Fly  1921 SQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKH-YLVKWKSLPYEDCTWELE---- 1980
            ::     .|.:::.:..|..    :|...:..|....|..|| :.::|    |.|....:|
pombe   294 NE-----INFQNKRYGSDSV----ILPGGLLHDSKLPEPGKHLFHLQW----YHDRFHNIEGFNL 345

  Fly  1981 EDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEK----TPVYKGGN------SLRPYQLE 2035
            .|.:|.|::.              .:::...||:|.|::    .|..:.|.      :|..:|.|
pombe   346 SDSNNQKVQD--------------DQQQQLEELFKDLDEQLVNDPTIREGTPAGLIPTLMEHQKE 396

  Fly  2036 GLNWLK-FSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGP-------FLVIAPLSTIPNW 2092
            ||.||| ....:....||||:||||||:|:|..:.:      |.|       .|:|.|:|.:..|
pombe   397 GLMWLKRLEESSKKGGILADDMGLGKTVQALALLVT------RPPESKSVKTTLIITPVSLLQQW 455

  Fly  2093 QREFEGWTDM------NVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTD 2151
            ..|.  .|.:      .|.::|||               ::..|:.::.:.:::::||:.:|..:
pombe   456 HNEI--LTKIAPSHRPTVYIHHGS---------------SKKHKIAEQLMSYDIVLTTYNVIAYE 503

  Fly  2152 YMDLKAFN---------------------WRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSG 2195
            :.:..|::                     |...::|||..:||||.....|...|...:|..|||
pombe   504 FKNKMAYDKSIEDNAPIKKFEHLPFFEAEWYRVILDEAQTIKNRNTLAARGCCLLESTYRWCLSG 568

  Fly  2196 TPLQNNISELFSLLNFLEPSQFSSQEEFMSEF-----GSLRTEEEVNKLQALLKPMMLRRLKD-- 2253
            ||:||.:.|.:||:.||....:|....|..:|     .::.|...:.:.:.|||.::|||.|:
pombe   569 TPMQNGVEEFYSLIKFLRIKPYSDWSSFSKDFTIPLSSNINTSAPMKRFRGLLKAVLLRRTKNTK 633

  Fly  2254 -DVEK--SLAPKEETIIEVELTNIQKKYYR----GILEQNFSFLKKGTTSANIPNLMNTMMELRK 2311
             |.:.  :|.||.....|.:|::.:.::|.    |...|...:|::||.:.:..:|:..::.||:
pombe   634 IDGKPILTLPPKTAVKSETDLSSSEMEFYNTLQSGAQIQMRKYLQEGTITTHYGSLLVLLLRLRQ 698

  Fly  2312 CCIHPYLLNGAEEQIQYD--FKSQH---------------------------------------- 2334
            .|.||:|:...|..:..:  |::::
pombe   699 ACCHPWLIVAREAAVDDNDSFQAKNRAIYNQIYPEAVNRLKLIETLQCSLCMDVVAELLIIVPCG 763

  Fly  2335 --------------GEDPESYYKNLILS------------------------AGKMVLID----- 2356
                          .||......|..:|                        :|...::|
pombe   764 HFLCRECLTHVITSSEDMAKQTSNENISPKCSVCEEYIDTERLLSYALFRRYSGMAPIVDADNKL 828

  Fly  2357 ------KLLPKLKAN---------------------------------------GHRVLIFSQMV 2376
                  :||||..:|                                       ..::|||||.|
pombe   829 RTENISELLPKQYSNILENRQMGMKIFTDPKHWTTSTKIEKALNAVKEIIKKQPTDKILIFSQFV 893

  Fly  2377 RCLDILE--------DYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGI 2433
            ..|::..        .||:|        .|.:....|.:|:..:....:.| |.|:..|||.:|:
pombe   894 SFLELFTVPFRQEGIKYLMY--------TGGLSTAERNQALINFEVDPNVR-VLLISLKAGNVGL 949

  Fly  2434 NLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYE----------REMFDKA 2488
            |||.|:.|||.|..|||..:.||..|.|||||.|.|.|.|::..||.|          ||:.|.|
pombe   950 NLTCANHVIILDPFWNPYIEEQAVDRAHRIGQDKPVNILRIVTNNTIEERVLALQDRKRELIDSA 1014

  Fly  2489 SMKLGLDKAVLQSMNTQGSKDGNNKQLS 2516
            ..:.||.:  :..:||        |:||
pombe  1015 LGEKGLRE--ISRLNT--------KELS 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	55/326 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	10/80 (13%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	13/62 (21%)
		PLN03142	2029..>2606	CDD:215601	161/685 (24%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
rrp2	NP_596602.1	HepA	<380..1016	CDD:440319	155/667 (23%)
		RING_Ubox	742..812	CDD:473075	4/69 (6%)