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Protein Alignment kis and Ercc6l

DIOPT Version :10

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	NP_666347.2	Gene:	Ercc6l / 236930	MGIID:	2654144	Length:	1240	Species:	Mus musculus

Alignment Length:	1352	Identity:	314/1352 - (23%)
Similarity:	512/1352 - (37%)	Gaps:	404/1352 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1960 TKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYK 2024
            ||..:.:.:.|  ::...:|.|:.|:|:.........:..|           ||::||.:
Mouse    53 TKKVMSRIQKL--QEALEQLAEEEDDDEFIDVCSSGLLLYR-----------ELYEKLFE----- 99

  Fly  2025 GGNSLRPYQLEGLNWLKFSWY--NTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLS 2087
                   :|.||:.:| :|.|  .....||||:||||||:|.:.|:..:::..:....|:|.|.:
Mouse   100 -------HQKEGIAFL-YSLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTN 156

  Fly  2088 TIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTD 2151
            .|..|..||..|| .|.|..:|||..|:          :|.|...:::  :..|:|||::|::.:
Mouse   157 LINTWVNEFAKWTPGMRVKTFHGSSKSE----------RTRSLTRIQQ--RNGVVITTYQMLLNN 209

  Fly  2152 YMDLKAFN-----WRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNF 2211
            :..|.:||     |...::||||::|:.:.|.....|.:...:|:||:|||:|||:.||:||.:|
Mouse   210 WQQLASFNGQAFVWDYVILDEAHKIKSASTKSAVCARAIPASNRLLLTGTPVQNNLQELWSLFDF 274

  Fly  2212 -LEPSQFSSQEEFMSEFGS--LRTEEE-------------VNKLQALLKPMMLRRLKDDVEK--- 2257
             .:.|...:.:.|..|:..  :|..|:             ...|..::||..|||.|::|:.
Mouse   275 ACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISENLMEIIKPYFLRRTKEEVQTKKA 339

  Fly  2258 ---------------------SLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPN 2301
                                 |||.|.:.|:.:.|..:|::.||..:              ::.:
Mouse   340 DNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQEEIYRKFV--------------SLDH 390

  Fly  2302 LMNTMME----------LRKCCIHPYLL---------------NGAEEQIQYDFKSQHGED--PE 2339
            :...:||          |:|.|.||.||               :..:|..|.|..:.:..|  |:
Mouse   391 IKELLMETRSPLAELGVLKKLCDHPRLLSARACRLLNLGTATFSAQDENEQEDVSNMNSIDHLPD 455

  Fly  2340 SYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNL 2404
               |.||..:|||:.:..||.:|:..||:.|:|||.::.|:|:|..|..:.:...||||.:....
Mouse   456 ---KTLIQESGKMIFLMSLLERLQDEGHQTLVFSQSIKILNIIERLLKNKHFKTLRIDGTVTHLW 517

  Fly  2405 RQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMV 2469
            .:|...:..:...:..||||.|:.||:|:.||||..|:|:|..|||..|.||..|.:||||::.|
Mouse   518 EREKRIQLFQQNKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENV 582

  Fly  2470 KIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKG------- 2527
            .:|||:...|.|.:::.:...|   |..:.|   |.|.|....:..:|:|:::|...|
Mouse   583 VVYRLITCGTVEEKIYRRQVFK---DSLIRQ---TTGEKKNPFRYFTKQELKELFTVGDLQKSAT 641

  Fly  2528 ----------------------AY------GAVMDDD--NAGDKFCEEDIDSI------------ 2550
                                  ||      ..:.|.|  ...|...:|::|.:
Mouse   642 QMQLQCLHAAQRRSDEKLDEHIAYLHLLGIAGISDHDLMFTRDLSVKEELDMLEDSQYIHQRVQK 706

  Fly  2551 ------------LKRRTQVI-----------TMESEKGSTFSKAS-------------FAASGNR 2579
                        ::|:|..|           :.:.:||:.|:|..             .|.|...
Mouse   707 AQFLVESESQNTVQRQTTGIEETWLKAQEFPSQQKKKGTEFNKPQPQPSRLLTKPTQVEAISSQM 771

  Fly  2580 SDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNENS 2644
            :.|||                   |::...     |||:..:::     .||..|......|..|
Mouse   772 ASITI-------------------CDQSAE-----SEPQEHSEV-----HDVTSLQGSHHFNSTS 807

  Fly  2645 DEEGGI-----GLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEK 2704
            | .|.|     |..|.............||    ...|.||:...|| :...|..|.||
Mouse   808 D-AGTIASLPQGAESIGEVSTDSLLSPAKG----FAAENDAMQKKGL-QASPGQEAPSE------ 860

  Fly  2705 GLLSFGW-GRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGE 2768
            .|.||.: .|.|....||.      ::|::|  .::|.:.......::.:::          |..
Mouse   861 NLGSFHYLPRESSKASLGP------NLDLQD--SVVLYHRSPTANENQNLES----------DVP 907

  Fly  2769 VQKISRDHSGLHNLVPRGRNGGKS------NKESTGVSTPAPGSASGSN-----SGNTTPAHKSS 2822
            :.:||.|.|.    .|....|.::      .||...:.:| |..|...|     |.:|.....|.
Mouse   908 MIEISDDLSE----PPSALQGAQAIEAQLELKEDDPLKSP-PQYACDFNLFLEDSADTRQNLSSK 967

  Fly  2823 ALDGSDKD----SGGINASAVAAAVTSIHDPNHWSKKEKY----------------DADAYLEGA 2867
            .|:..:|:    |...|:.|.:|...|: |.:..|.:|..                |.|...|.|
Mouse   968 FLEHVEKEKSLQSPAANSRAKSALTLSL-DSSPKSDEESEVISVKTKSKTRRILSDDEDEDEEDA 1031

  Fly  2868 YKKHLGRHANKVLLRVRMLYYIQHEVIGDF----VQQIKDNTPIS-ELPIR---PPPTPDQVPSS 2924
            :|   |.|.|.:             .|..|    |:|...:||.| ..|.|   .|.||.:
Mouse  1032 FK---GSHTNSI-------------NISPFPFSSVKQFDASTPQSGSNPSRRFFSPKTPGE---- 1076

  Fly  2925 WWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDD 2989
                        |.|..|........|:..|:..          ||:         :|...:.|:
Mouse  1077 ------------VNTSLHSRRSLASRRSLINVVL----------DDV---------EDMEERLDN 1110

  Fly  2990 GDEV-----------DDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENA---SGGND 3040
            ..|.           :::....|::..|.......||.|.|....|:|....||..|   |..:.
Mouse  1111 SSEEESEPGLSEENNEEEALACTEEQPSGATLASGNKSSNLTMSEPTSPAPQSSPCAPEPSSSDP 1175

  Fly  3041 KTESENDATTVSESSYKSEVLPGK--------GSDLDVSVAQQDALSATPEL 3084
            ..:...|....:.:.|:|.|..||        ...|:..|...|..||.||:
Mouse  1176 MPDPPQDLAVEAGNDYESLVARGKELKECGKIQEALNCLVKALDIKSADPEV 1227

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.