Protein Alignment kis and Zranb3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_006529471.1
• Gene: Zranb3 / 226409
• MGIID: 1918362
• Length: 1120
• Species: Mus musculus
• Alignment Length: 877
• Identity: 203/877 - (23%)
• Similarity: 325/877 - (37%)
• Gaps: 231/877 - (26%)

  Fly  2006 KKRPHPEL-------WKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQ 2063
            ||.|.|::       :.:|:..| .|....|.|:|.:|   :.|:......|::|||||||||||
Mouse    12 KKAPTPQISCLTSESYTQLDFLP-DKLRTKLLPFQKDG---IVFALRRDGRCMVADEMGLGKTIQ 72

  Fly  2064 SLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGW------TDMNVVVYHGSVTSKQMIQDYEY 2122
            ::..   .|.|....|.|::.|.|....|..|.|.|      .::|||:
Mouse    73 AIAI---AYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVM---------------- 118

  Fly  2123 YYKTESGKVLKEPIKFNVLITTFEMIVTD---YMD-LKAFNWRLCVIDEAHRLKNRNC---KLLE 2180
             .||:.|::...    .|.:..:.::.||   .:| |...|:|:.::||:|.:|:|..   |:|.
Mouse   119 -NKTDIGRIPGS----RVTVLGYGLLTTDAETLLDALNTQNFRVVIVDESHYMKSRTAARSKILL 178

  Fly  2181 GLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSE--------FG-----SLRT 2232
            .:.| .....:||:|||......|||..:..|.|.:|.:..|:...        ||     ..|.
Mouse   179 PMVQ-KARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWDCRG 242

  Fly  2233 EEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSA 2297
            ...:::|..||..:|:||||.:|...|.||....|..:|.....|      |.|.|| ::.....
Mouse   243 ASNLSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPAAVK------ELNASF-EEWQKLM 300

  Fly  2298 NIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKL 2362
            ..||                  :||.|.:.       |.....:.:..|..||.:....|:|  |
Mouse   301 RAPN------------------SGAMETVM-------GLITRMFKQTAIAKAGAVKDYIKML--L 338

  Fly  2363 KANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTK 2427
            :.:..:.|:|:..:..|....:.::..|..:.||||.:..:.|...::::.|....| |.:|..:
Mouse   339 QNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQ 402

  Fly  2428 AGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKL 2492
            |.|.|:..|||..|:..:..|:|.:..||:.|.|||||...|.|:.|:...|
Mouse   403 AAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGT------------- 454

  Fly  2493 GLDKAVLQSMNTQGSKDG---NNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRR 2554
             ||..:...:|.:....|   |.::...:..||..:|..:....:.....|.| ||..||:...
Mouse   455 -LDSLMWAMLNRKAQVTGSTLNGRKEKLQATEDDKEKWGFLQFAEAWTPSDSF-EELKDSVFTH- 516

  Fly  2555 TQVITMESEKGSTFSKASFAASGNRS-DITIDDPDFWTKWAKKVDIDPD---ACERDETEDLVLS 2615
                 .|.||..............|. :.|.|||:   .:.:|:.:..|   ....|.|.|....
Mouse   517 -----FEKEKQHDIRSFFLPKLKKRQLETTCDDPE---AFKEKITVASDPRKMATSDSTADKNGC 573

  Fly  2616 EPRRRTQIKRYGHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDA 2680
            ||    :.||        |.|..:.:.:|..|.|..|::|..            :.|.:...:..
Mouse   574 EP----EAKR--------LKSLSTEDHSSALEEGPSLQARAT------------SMEVVHEVKPP 614

  Fly  2681 LAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQ 2745
            ||:..|.|                                    :||:      |.     :|
Mouse   615 LASPALPE------------------------------------KGWQ------CG-----FC-- 630

  Fly  2746 VYKGDEKIKTFIWDLITP----TEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPA--- 2803
                     ||:.:...|    .|:...:...|:|     |....:|...:.:|||..|..|
Mouse   631 ---------TFLNNPGLPYCEMCENPRSRAAGRNH-----LQDNNKNDEDAAQESTSKSDQAGLE 681

  Fly  2804 -----PGSASGSNSGNTTPAHKSSALDGSDKD 2830
                 |.......|.|:    |..||:|..:|
Mouse   682 CERQCPERLEAEQSANS----KEEALEGGGED 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310
		PLN03142	2029..>2606	CDD:215601	152/609 (25%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Zranb3	XP_006529471.1	HepA	<28..468	CDD:440319	134/517 (26%)
		DEXHc_HARP_SMARCAL1	41..260	CDD:350768	67/246 (27%)
		ZnF_RBZ	625..647	CDD:197784	7/43 (16%)
		RanBP2-type Zn finger	625..644	CDD:275376	6/40 (15%)
		HNHc	1025..1090	CDD:238038