Protein Alignment kis and Chd3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_017169944.1
• Gene: Chd3 / 216848
• MGIID: 1344395
• Length: 2111
• Species: Mus musculus
• Alignment Length: 2467
• Identity: 614/2467 - (24%)
• Similarity: 903/2467 - (36%)
• Gaps: 803/2467 - (32%)

  Fly  1276 EYSEGMGD-LSQDVHSANELDTSTD-------GSGKKKKPRKPRTPK----DPNKPPRDRTPKAK 1328
            |..|..|| ..::|.:|:|.|...|       |.|..:...:...|.    .|..||....|
Mouse    22 EEEEEEGDEEEEEVEAADEDDEEEDEEGVLGRGPGHDRSRDRHSPPSCHLFPPPPPPLPPPP--- 83

  Fly  1329 KPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTS 1393
             |.|.:|.....:...||||....|::|                 :|||
Mouse    84 -PPDKDDIRLLPSALGVKKRKRGPKKQK-----------------ENKP---------------- 114

  Fly  1394 GGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSR 1458
                  |:            ||...:.:.|.|.|.|                  ||..|..:.|
Mouse   115 ------GK------------PRKRKKLDSEEEFGSE------------------RDEYREKSES- 142

  Fly  1459 RNANSEEG-GSARKNRGSLSAKALK--KRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKR 1520
              ..||.| |..||.|.....|..|  |||.||    |.||....::                 :
Mouse   143 --GGSEYGTGPGRKRRRKHREKKEKKTKRRKRG----EGDGGHKQVE-----------------Q 184

  Fly  1521 RSSRNTQRKKYIDDVMLRFSDDENSLLV--------ASPVKKDKKPSANASNSNAGSDVEKTEPQ 1577
            :||........::||...||:::...|.        ..|:...|.|..               |.
Mouse   185 KSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI---------------PM 234

  Fly  1578 SGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDE 1642
            |........:..|..:|.|...|:...|:::.:|.|....|:|. |.::|....|:
Mouse   235 SKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSA-AVSSATPIAPS--------- 289

  Fly  1643 DSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEG-------------DEK 1694
                                ..|....|.|..:.:...:..|.|.:.:|             |.:
Mouse   290 --------------------GPPPALPPPPAPEIQPPPIRRAKTKEGKGPGHKRRNKSPRVPDGR 334

  Fly  1695 FKTEGES------KKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKS 1753
            .|..|:.      |..|...:..|..|.|.:.:...|.|.::|        |.|...|....|..
Mouse   335 KKLRGKKMAPLKIKLGLLGGKRKKAGSCAFQSEEGHEPEAEES--------DLDSGSVHSASGWP 391

  Fly  1754 DKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGS 1818
            |         ..|:.::..:.....|...||..      ..|..:.|||....|.|......:..
Mouse   392 D---------GPVRAKKLKRGRPGRKKKKVLGC------PAVTGEEEVDGYETDHQDYCEVCQQG 441

  Fly  1819 DEKSTDDSNP------------EEATTEK------NKESLEIEG---EKERVKEGEESVKKENDE 1862
            .|....|:.|            :.|...|      .||.::.|.   |:|..:||||..|:|.|:
Mouse   442 GEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEEYEEEGEEGEKEEEDD 506

  Fly  1863 KTE------------------------------ADMEN--------------------------K 1871
            ..|                              .|:.|                          :
Mouse   507 HMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGE 571

  Fly  1872 PEPVFI----------DV-----------EEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRR 1915
            | ||.:          ||           .|:|||:...||.||.|..|.:|   :.......|.
Mouse   572 P-PVAVPAPQQADGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQL---EIFHLVMYRN 632

  Fly  1916 FQQKQSQQLNIFENIEDEPFNQDF--------TEVDRVLD-------------------MSVH-- 1951
            :|:|         |..|||...|:        ::..:|.|                   |:||
Mouse   633 YQRK---------NDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRI 688

  Fly  1952 -TDETSGETTKHYLVKWKSLPYEDCTWELEE----DVDNDKIEQYLRFNKI------PQRSEWKS 2005
             ......:...|||||||.|||:..|||.:|    :.|:.| :.|.|..::      .|..::|.
Mouse   689 INHSMDKKGNYHYLVKWKDLPYDQSTWEEDEMNIPEYDDHK-QSYWRHRELIMGEDPAQPRKYKK 752

  Fly  2006 KKR----------PHPELWKKLEKTP--VYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGL 2058
            ||:          |..:...|.|..|  :...|.:|..|||||||||:|||....:.||||||||
Mouse   753 KKKELQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGL 817

  Fly  2059 GKTIQSLTFVHSVYEYG-IRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYE 2121
            |||||::.|::|:|:.| .:|||||.||||||.||:|||:.|. ...||.|.|...|:.:|::.|
Mouse   818 GKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENE 882

  Fly  2122 YYYKTESGKVLKE--------PIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKL 2178
            :.::..:.|..|:        .:||:||:|::|:|..|...|.:..|...|:||||||||...|.
Mouse   883 FSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKF 947

  Fly  2179 LEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALL 2243
            ...|....::|::||:|||||||:.|||.|||||.|.:|::.|.|:.||..:..|:::.||..||
Mouse   948 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLL 1012

  Fly  2244 KPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFL-KKGTTSANIPNLMNTMM 2307
            .|.||||||.||.|::..|.|.|:.|||:.:|||||:.||.:||..| .:|  ..|..:|:|.||
Mouse  1013 GPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRG--GGNQVSLLNIMM 1075

  Fly  2308 ELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKN--LILSAGKMVLIDKLLPKLKANGHRVL 2370
            :|:|||.||||...|        ..:..:.|...|:.  ||.|:||::|:.|:|.|||..|||||
Mouse  1076 DLKKCCNHPYLFPVA--------AMESPKLPSGAYEGGALIKSSGKLLLLQKMLRKLKEQGHRVL 1132

  Fly  2371 IFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINL 2435
            |||||.:.||:|||:|.|..|.:|||||.|.|.||||||||::.||:.:|.|||.|:||||||||
Mouse  1133 IFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINL 1197

  Fly  2436 TAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQ 2500
            ..||||||:||||||.||:||.:|.|||||...|.|||.:.|.:.|..:...|..|:.|...|::
Mouse  1198 ATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVR 1262

  Fly  2501 SMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDK---------FCEEDIDSILKRR-- 2554
            .  ..|||.|:   :||:|::|:||.|. ..:..|:|.|:.         :..|.|..:|.|.
Mouse  1263 P--GLGSKAGS---MSKQELDDILKFGT-EELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQD 1321

  Fly  2555 ----TQVITMESEKGSTFSKASFAASGNRSDITID-------------DPDFWTKWAKKVDIDPD 2602
                |.|..| :|..|:|..|.:..   |.:..|:             |||:|.|..:.
Mouse  1322 ATEDTDVQNM-NEYLSSFKVAQYVV---REEDKIEEIEREIIKQEENVDPDYWEKLLRH------ 1376

  Fly  2603 ACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSE---------ESSNENSDE--EGGIGLRSRR 2656
             ....:.|||..:..:.:...|:..:.|..:.:.:         |..:|:.||  ||       |
Mouse  1377 -HYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEG-------R 1433

  Fly  2657 RKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELG 2721
            |:.||....||   |:.:|   ..||.:|      ||                        :|:.
Mouse  1434 RQSKRQLRNEK---DKPLP---PLLARVG------GN------------------------IEVL 1462

  Fly  2722 QFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFI-----WDLITPTEDG-EVQKISRDHSGLH 2780
            .|....|                         |.|:     |.:  |.:|. ..|.:.||..
Mouse  1463 GFNTRQR-------------------------KAFLNAVMRWGM--PPQDAFTTQWLVRDLR--- 1497

  Fly  2781 NLVPRGRNGGKSNKESTGVST------PAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAV 2839
                     ||:.||.....:      ..||:                  |||
Mouse  1498 ---------GKTEKEFKAYVSLFMRHLCEPGA------------------DGS------------ 1523

  Fly  2840 AAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYI-------QH------ 2891
                                 :.:.:|..::.|.|  .:||.|:.::..:       :|
Mouse  1524 ---------------------ETFADGVPREGLSR--QQVLTRIGVMSLVKKKVQEFEHINGRWS 1565

  Fly  2892 --EVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADP 2954
              |::.|...:.|.::..|......|.||:   :|..|..|..|.                 |.|
Mouse  1566 MPELMPDPSAESKRSSRASSPTKTSPTTPE---ASTTNSPCTSKP-----------------ATP 1610

  Fly  2955 NLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGG-----DN 3014
                    .....||.:..   |:::||..::.:..::....|.....:.||......     ::
Mouse  1611 --------APSEKGDGVRT---PLDKDDTENQEEKPEKNSKVGEKMEAEVDSPSPAPSLGERLEH 1664

  Fly  3015 KDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGSD---LDVSVAQQD 3076
            :..||:.|.|...|::..|....| |:.:|.::.|            ||:..:   |||...::.
Mouse  1665 RKILLEDEAPGVPGETEPEPGYRG-DREKSASEPT------------PGERGEEKPLDVQEHRER 1716

  Fly  3077 ALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSP-----EAAGKAQGTGVQTGDAGELDIES 3136
            ....|.:|...::..  |.|.::...   .|.|...|     |...|.:.. ....|.|..::.:
Mouse  1717 TEGETGDLGKRAEDV--KADRELRLG---PPRDEPRPNGRREEKVEKPRFM-FNIADGGFTELHT 1775

  Fly  3137 EKKDNEKETKESTGDAPAVEAKKDS----AAIARAEGDKTESCTNNATTNISTTTTTTTITNTTT 3197
             ...||:....|:|....:..::..    |.|......:.:...|:|...|
Mouse  1776 -LWQNEERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAI-------------- 1825

  Fly  3198 TTNNPSSKAANSNNTTDHANS---------------------NSHLGLDEE-------------- 3227
             .|.|....||..|..:..|.                     .::|.|.:|
Mouse  1826 -INEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAE 1889

  Fly  3228 -------------ESVAGSYPPTV------------------AAVEDATTMWPSMQDLNTRLRRV 3261
                         ||:||:.|...                  ||.|.|..:
Mouse  1890 AECLAESHQHLSKESLAGNKPANAVLHKGKGRGGPARGRAHNAASEPAGGI-------------- 1940

  Fly  3262 ITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSG------------ 3314
                   .::.|.:....|  ...|.:||..|.|:....|..|...|.|.|:.
Mouse  1941 -------AERHEGRCDPPA--SHAVPNTPHRSPPSDVRAQHPQPAGQQGHGASPHTGLSPGSLRH 1996

  Fly  3315 GSGIGSSAQ---HDASGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGGAGVMPA 3373
            .||:..|.|   ....||..:.|..........:.....||||....|:|    ||.|:..|
Mouse  1997 TSGVRGSLQRRTRRGPGRRRRQLQPDACRVLHHSHHQRPSSAGEEREGNG----GGVGIRRA 2054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	43/183 (23%)
		PTZ00121	<1419..1923	CDD:173412	120/631 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	27/143 (19%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	24/91 (26%)
		PLN03142	2029..>2606	CDD:215601	272/617 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd3	XP_017169944.1	CHDNT	200..253	CDD:462357	10/67 (15%)
		PHD1_CHD_II	434..476	CDD:277006	5/41 (12%)
		PHD2_CHD_II	510..552	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	557..635	CDD:349314	17/81 (21%)
		CD2_tandem_CHD3-4_like	680..734	CDD:349309	20/54 (37%)
		PLN03142	771..>1325	CDD:215601	262/569 (46%)
		DEXHc_CHD3	788..1019	CDD:350813	109/230 (47%)
		DUF1087	<1366..1409	CDD:461922	10/49 (20%)
		CHDII_SANT-like	1430..1569	CDD:461920	42/273 (15%)
		PHA03169	1589..>1759	CDD:223003	40/218 (18%)
		CHDCT2	1791..1917	CDD:462358	19/140 (14%)