Protein Alignment kis and Smarca4

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_011240739.1
• Gene: Smarca4 / 20586
• MGIID: 88192
• Length: 1670
• Species: Mus musculus
• Alignment Length: 2164
• Identity: 516/2164 - (23%)
• Similarity: 792/2164 - (36%)
• Gaps: 678/2164 - (31%)

  Fly  1005 QDDLQE--KPTAEMEQTQLGQSLGDLSKSLLEEPKTVEESGED-KSQSAPGVAPPADPIIPVTQP 1066
            ||::.:  ||...|.:           |.:.::|:..:..|.. :|.:..|:|||..   |:.|.
Mouse    86 QDNMHQMHKPMESMHE-----------KGMPDDPRYNQMKGMGMRSGAHTGMAPPPS---PMDQH 136

  Fly  1067 PQQQMPPIGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGAP--GMYPPYPMLHQQEIAAL---QQQ 1126
            .|....|:|...|..:|   ..|.|....|.|....||||  |..|  ..|.||.....   |.|
Mouse   137 SQGYPSPLGGSEHASSP---VPASGPSSGPQMSSGPGGAPLDGSDP--QALGQQNRGPTPFNQNQ 196

  Fly  1127 IQELYCMPPGHELQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLLNQQ 1191
            :         |:|:.|....:|..|...|..|          ..:..|...||   ||   :.||
Mouse   197 L---------HQLRAQIMAYKMLARGQPLPDH----------LQMAVQGKRPM---PG---MQQQ 236

  Fly  1192 MVESPQVS-STTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLMDISGNVAMGAANAVSSIPTTQL 1255
            |...|..| |.||.|.|........|                         |.|....|.|
Mouse   237 MPTLPPPSVSATGPGPGPGPGPGPGP-------------------------GPAPPNYSRP---- 272

  Fly  1256 PVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDGSGKKKKPRKPR--TPKDPNK 1318
                                   .|||                   |....|..|.  .|..|.:
Mouse   273 -----------------------HGMG-------------------GPNMPPPGPSGVPPGMPGQ 295

  Fly  1319 PPRDRTPKAKKPKDP--NDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPK 1381
            ||..  |....|:.|  |....|.||..:..               .:.||..|..   .|.||.
Mouse   296 PPGG--PPKPWPEGPMANAAAPTSTPQKLIP---------------PQPTGRPSPA---PPAVPP 340

  Fly  1382 AGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAG-DPASTP 1445
            |.|.....:|         :||.....|...:|....:..         :..:....| ||....
Mouse   341 AASPVMPPQT---------QSPGQPAQPAPLVPLHQKQSR---------ITPIQKPRGLDPVEIL 387

  Fly  1446 SRRDRKRSTARSRR-----NANSEEGGSARKNRGSLSAKALK----KRRNRGRIVPESDGEDDTL 1501
            ..|:.:.....:.|     |......|..| .:.::..|||:    :|:.|..:|
Mouse   388 QEREYRLQARIAHRIQELENLPGSLAGDLR-TKATIELKALRLLNFQRQLRQEVV---------- 441

  Fly  1502 DRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSN 1566
                                             |.:|......:.|.|...|:.|:.|...:..
Mouse   442 ---------------------------------VCMRRDTALETALNAKAYKRSKRQSLREARI- 472

  Fly  1567 AGSDVEKTEPQSGAEGD-AAQEVGEEKSNLPLDESSQLEA--SSSTSAVAEKERQISTDAANAAM 1628
                .||.|.|...|.: ..::..:|..|..|..:.....  .|.|..:.:..:.::|..||...
Mouse   473 ----TEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFREYHRSVTGKLQKLTKAVATYHANTER 533

  Fly  1629 SSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDE 1693
            ..|..    |...|...:.:|:.....|.|:||         :.|:|:..:.|.:.|
Mouse   534 EQKKE----NERIEKERMRRLMAEDEEGYRKLI---------DQKKDKRLAYLLQQT-------- 577

  Fly  1694 KFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESK 1758
                 .|...:||   |...:..|.:| :||:.:....||::........:..|.
Mouse   578 -----DEYVANLT---ELVRQHKAAQV-AKEKKKKKKKKKAENAEGQTPAIGPDG---------- 623

  Fly  1759 PEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKST 1823
             |...||.:..:....:...:|..:||...|             .||...::.:....|.:....
Mouse   624 -EPLDETSQMSDLPVKVIHVESGKILTGTDA-------------PKAGQLEAWLEMNPGYEVAPR 674

  Fly  1824 DDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRN 1888
            .||                          |||..:|.:|:.|.:.....:|..:.|||
Mouse   675 SDS--------------------------EESGSEEEEEEEEEEQPQPAQPPTLPVEE------- 706

  Fly  1889 FSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTD 1953
                                 ..||                  .:|.:.|.:|||
Mouse   707 ---------------------KKKI------------------PDPDSDDVSEVD---------- 722

  Fly  1954 ETSGETTKHYLVKWKSLPYEDCTWELEEDVDND-KIEQYLRFNKIPQRSEWKSKKRPHPELWKKL 2017
                  .:|.:...|            :|||:: .:.|.|      .|.........| .:.:::
Mouse   723 ------ARHIIENAK------------QDVDDEYGVSQAL------ARGLQSYYAVAH-AVTERV 762

  Fly  2018 EKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY-GIRGPFL 2081
            :|.........|:.||::||.||...:.|..|.|||||||||||||::..:..:.|: .|.||||
Mouse   763 DKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFL 827

  Fly  2082 VIAPLSTIPNWQREFEGWTDMNV-VVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTF 2145
            :|.||||:.||..||:.|....| |.|.||..:::     .:..:..||       |||||:||:
Mouse   828 IIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARR-----AFVPQLRSG-------KFNVLLTTY 880

  Fly  2146 EMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH----RVLLSGTPLQNNISELF 2206
            |.|:.|...|....|:..::||.||:||.:|||.:   .||..:    |:||:||||||.:.||:
Mouse   881 EYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ---VLNTHYVAPRRLLLTGTPLQNKLPELW 942

  Fly  2207 SLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE---VNKLQALLKPMMLRRLKDDVEKS 2258
            :|||||.|:.|.|...|...|.:          |..||.   :.:|..:|:|.:|||||.:||..
Mouse   943 ALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQ 1007

  Fly  2259 LAPKEETIIEVELTNIQKKYYR-----GIL-----EQNFSFLKKGTTSANIPNLMNTMMELRKCC 2313
            |..|.|.:|:.:::.:|:..||     |:|     |::    |||  ......||||:|:|||.|
Mouse  1008 LPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKD----KKG--KGGTKTLMNTIMQLRKIC 1066

  Fly  2314 IHPYLLNGAEEQIQYDFKSQH---------GEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRV 2369
            .|||:....||..     |:|         |.|       |..::||..|:|::||||:|..|:|
Mouse  1067 NHPYMFQHIEESF-----SEHLGFTGGIVQGLD-------LYRASGKFELLDRILPKLRATNHKV 1119

  Fly  2370 LIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGIN 2434
            |:|.||...:.|:|||..||.:.:.|:||..:...|...:..:::|||:.|:|||.|:|||||:|
Mouse  1120 LLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLN 1184

  Fly  2435 LTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVL 2499
            |.:||||||:||||||..|||||.|.|||||:..|::.||...|:.|.::...|..||.:|:.|:
Mouse  1185 LQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVI 1249

  Fly  2500 QSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEK 2564
            |:    |..|   ::.|..|....|:     |:::.:       |:|              ||..
Mouse  1250 QA----GMFD---QKSSSHERRAFLQ-----AILEHE-------EQD--------------ESRH 1281

  Fly  2565 GSTFS-KASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGH 2628
            .||.| .||||.       |...|         ..::||           |.||..:       .
Mouse  1282 CSTGSGSASFAH-------TAPPP---------AGVNPD-----------LEEPPLK-------E 1312

  Fly  2629 EDVMELNSEESSNE---NSDEEGGIGLR---SRRRKEKRDRAREKKGNDEYIPRERDALAALGLE 2687
            ||  |:..:|:.|:   ..:||..:.:|   .|||:|.|:            |:.:..|    :|
Mouse  1313 ED--EVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARN------------PKRKPRL----ME 1359

  Fly  2688 EIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWR---DVDVEDCARIILLYCLQVYKG 2749
            |.:..:|...:..:||:        ...|..|...|.||.|   :||..|..
Mouse  1360 EDELPSWIIKDDAEVER--------LTCEEEEEKMFGRGSRHRKEVDYSDSL------------- 1403

  Fly  2750 DEK--IKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNS 2812
            .||  :||     :...|:|.:::|..:        .|.:...:..|..             |.:
Mouse  1404 TEKQWLKT-----LKAIEEGTLEEIEEE--------VRQKKSSRKRKRD-------------SEA 1442

  Fly  2813 GNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYK-KHLGRHA 2876
            |::||...:.:.|..::...........|...|.:.|| .:||.|...||.::  || ...||..
Mouse  1443 GSSTPTTSTRSRDKDEESKKQKKRGRPPAEKLSPNPPN-LTKKMKKIVDAVIK--YKDSSSGRQL 1504

  Fly  2877 NKVLLRVRML-----YY--IQHEVIGDFVQQIKD---NTPISELPIRPPPTPDQVPSSWWNPICC 2931
            ::|.:::...     ||  |:..|  || ::||:   |.....|                |.:..
Mouse  1505 SEVFIQLPSRKELPEYYELIRKPV--DF-KKIKERIRNHKYRSL----------------NDLEK 1550

  Fly  2932 DKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPIN-------EDDANSKH-D 2988
            |..||       |:..:....:.:|.:         .|.:.:.|:..:       |||:..:. :
Mouse  1551 DVMLL-------CQNAQTFNLEGSLIY---------EDSIVLQSVFTSVRQKIEKEDDSEGEESE 1599

  Fly  2989 DGDEVDDDGTTTTKDSDSTKLTGGDN---KDSLLDPERPSSSGKSSSENASGGNDKTESENDATT 3050
            :.:|.:::|:.:...|...|:..|..   :|.|....|..|.|..:....|..:.:.|.|.|.:
Mouse  1600 EEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRS- 1663

  Fly  3051 VSESSYKSEVLPGKGSDLD 3069
                        |.||:.|
Mouse  1664 ------------GSGSEED 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	50/214 (23%)
		PRK12678	1319..>1500	CDD:237171	36/192 (19%)
		PTZ00121	<1419..1923	CDD:173412	81/516 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/66 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	11/58 (19%)
		PLN03142	2029..>2606	CDD:215601	229/615 (37%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Smarca4	XP_011240739.1	Med15	62..>237	CDD:312941	48/194 (25%)
		QLQ	191..225	CDD:462622	9/52 (17%)
		Smc	<384..>590	CDD:440809	47/283 (17%)
		HSA	480..552	CDD:214727	13/75 (17%)
		BRK	632..676	CDD:197800	7/56 (13%)
		DEXHc_SMARCA4	751..1001	CDD:350820	100/265 (38%)
		PLN03142	770..>1252	CDD:215601	208/518 (40%)
		SnAC	1342..1409	CDD:464219	23/103 (22%)
		Bromo_SNF2L2	1481..1587	CDD:99947	28/142 (20%)