Protein Alignment kis and chd-3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_510140.1
• Gene: chd-3 / 181421
• WormBaseID: WBGene00000482
• Length: 1787
• Species: Caenorhabditis elegans
• Alignment Length: 1991
• Identity: 526/1991 - (26%)
• Similarity: 809/1991 - (40%)
• Gaps: 586/1991 - (29%)

  Fly  1418 NEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALK 1482
            ::|:.|:..||||::.      |........|.:...........:|
 Worm     2 SDDQHESIDGDETMEE------DSMLAEGHEDGEEDVGEDEEEVETE------------------ 42

  Fly  1483 KRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLL 1547
                      ||.|...|.::..||         ..|::..:.:.:||             |:..
 Worm    43 ----------ESQGVPTTSEKKKPP---------PKKKKGGKKSSKKK-------------NNCD 75

  Fly  1548 VASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAV 1612
            ...|.   |..||..|.:...:||:.         |..||
 Worm    76 YPDPY---KSTSAEISAAIGLTDVDV---------DYEQE------------------------- 103

  Fly  1613 AEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKREL----------ILDKPKE 1667
               |.|..|:..|.:...||..:.:|.|   :.|.::....::..:|.          |..:.:.
 Worm   104 ---EFQSITNLKNFSSLVKPYILKVNPG---TNVTKMYPLFQVKYKEFQDHMTAHGKSIQKQQRA 162

  Fly  1668 K---APEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPD 1729
            |   .|.|...:||. :.:.|........:..::||.....:|.|...|    ::...|::.|.:
 Worm   163 KFVPVPVPVTPQEKI-IPQKTRSSARRKRRDGSDGEGGGHDSDQEFEAL----IKQHEKQQDEAE 222

  Fly  1730 DSKKSDEDNK---DKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKS----STVLTAD 1787
            ..|:....|:   ..||.:...|..::.|.::.|:.......:||.:...:|..    .|...|.
 Worm   223 KGKEEARINRAAAKVDKRKAALESARASKRARKEQGVVEENHQENCEVCNQDGELMLCDTCTRAY 287

  Fly  1788 HA--------KEPE-------------TVLEKMEVDEKANDDQSAVSKAEGS------------- 1818
            |.        :.||             .||...|...|||.|...:.|...:
 Worm   288 HVACIDENMEQPPEGDWSCPHCEEHGPDVLIVEEEPAKANMDYCRICKETSNILLCDTCPSSYHA 352

  Fly  1819 ---DEKSTDDSN----------PEEATTEKNKESL-----EIE-GEKERVKEGEESVKKENDEKT 1864
               |...|:...          ||.|  ::.::.|     ||. .|....|||||:.|.:...|.
 Worm   353 YCIDPPLTEIPEGEWSCPRCIIPEPA--QRIEKILSWRWKEISYPEPLECKEGEEASKDDVFLKP 415

  Fly  1865 EADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQK-QSQQLNIFE 1928
            ...||.:.|      .|:|||::..:|..|||.:|..:   |....|.:|.:.:| .|:...|||
 Worm   416 PRKMEPRRE------REFFVKWKYLAYWQCEWLSETLM---DVYFTALVRMYWRKVDSENPPIFE 471

  Fly  1929 -------NIEDEPF-----------NQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDC 1975
                   :.:.:|:           ..::.::.|:::   |.  :..::.:.||||||.|.||..
 Worm   472 ESTLSRHHSDHDPYKLRERFYQYGVKPEWMQIHRIIN---HL--SYAKSQQDYLVKWKELSYEHA 531

  Fly  1976 TWELEEDVD-------------------NDKIEQYLRFNKIPQRSEWKS------------KKRP 2009
            ||| .:|.|                   ||::.:.:: ..|.::.|.|.            |||.
 Worm   532 TWE-RDDTDIANYEDAIIKYWHHRERMLNDEVPRNVQ-KMIAKQREAKGLGPKEDEVTSRRKKRE 594

  Fly  2010 HPELWKKLEKTP--VYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVY 2072
            ..::.||.|..|  :.:.|.:|.||||||:|||:..|.|..:.|||||||||||:|||||::::.
 Worm   595 KIDILKKYEVQPDFISETGGNLHPYQLEGINWLRHCWSNGTDAILADEMGLGKTVQSLTFLYTLM 659

  Fly  2073 EYG-IRGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQDYEYYY---------KT 2126
            :.| .:||||:.||||||.||:||.|.| .|..||.|.|...|:.:|:::|:.:         |.
 Worm   660 KEGHTKGPFLIAAPLSTIINWEREAELWCPDFYVVTYVGDRESRMVIREHEFSFVDGAVRGGPKV 724

  Fly  2127 ESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRV 2191
            ...|.| |.:||:||:|::|.|..|...|.:.:|...|:||||||||......:.||:.|:::||
 Worm   725 SKIKTL-ENLKFHVLLTSYECINMDKAILSSIDWAALVVDEAHRLKNNQSTFFKNLREYNIQYRV 788

  Fly  2192 LLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVE 2256
            ||:|||||||:.|||.|||||.|.:|:..|.|.:||..:..|:::.||..||.|.||||||.||.
 Worm   789 LLTGTPLQNNLEELFHLLNFLAPDRFNQLESFTAEFSEISKEDQIEKLHNLLGPHMLRRLKADVL 853

  Fly  2257 KSLAPKEETIIEVELTNIQKKYYRGILEQNFSFL--KKGTTSANIPNLMNTMMELRKCCIHPYLL 2319
            ..:..|:|.|:.|||:.:|||||:.||.:||..|  |.|.|..   :|:|.:|||:|||.||||
 Worm   854 TGMPSKQELIVRVELSAMQKKYYKNILTRNFDALNVKNGGTQM---SLINIIMELKKCCNHPYL- 914

  Fly  2320 NGAEEQIQYDFKSQHGEDPESYYKN-------LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVR 2377
                      |.....|.|:  .||       ||.:|||.||:.|:|.|||..||||||||||..
 Worm   915 ----------FMKACLEAPK--LKNGMYEGSALIKNAGKFVLLQKMLRKLKDGGHRVLIFSQMTM 967

  Fly  2378 CLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVI 2442
            .||||||:.....|.:|||||.|.|..||:|||||:.||:.:|||||.|:||||||||..|||||
 Worm   968 MLDILEDFCDVEGYKYERIDGSITGQQRQDAIDRYNAPGAKQFVFLLSTRAGGLGINLATADTVI 1032

  Fly  2443 IYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGS 2507
            ||||||||.||:||.:|.||:||:..|.|||.:.:.:.|..:...|..|:.|...|:::  ..|:
 Worm  1033 IYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKGSVEERITSVAKKKMLLTHLVVRA--GLGA 1095

  Fly  2508 KDGNNKQLSKKEIEDLLKKG-----------AYGAVMDDDNAGDKFCEED--------IDSILKR 2553
            |||  |.:||.|::|:|:.|           ..||  |.:....|...|.        :|.:|.|
 Worm  1096 KDG--KSMSKTELDDVLRWGTEELFKEEEAPVEGA--DGEGTSSKKPNEQEIVWDDAAVDFLLDR 1156

  Fly  2554 RTQVITMESEKG--------STFSKASF------AASGNRSDITI-------DDPDFWTKWAKKV 2597
            ..:....:.||.        |:|..|::      .|..:..:..:       .||::|.|..|
 Worm  1157 NKEEEGQDGEKKEHWTNEYLSSFKVATYNTKEADDADDDEDETEVIKEGTEEQDPNYWEKLLK-- 1219

  Fly  2598 DIDPDACERD-ETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNENSDEEG-------GIGLRS 2654
                ...|:| |||...|.:.:|..:...|..|::.:..|.:::.:..:::|       |..|::
 Worm  1220 ----HHYEQDQETELQKLGKGKRVRRQVNYASENMGQDWSAQNNQQQEEDDGSEYGSDNGELLQT 1280

  Fly  2655 RRRKEKRDRAREKK------------GNDEYI---PRER----DALAALGL--EEIQYGNWA--- 2695
            ....|:|.|.||::            |..|.:   ||:|    :|:...|:  :::...:|.
 Worm  1281 DEDYEERRRRREERSEKLPPLLAKVNGQIEVLGFNPRQRKAFYNAVMRWGMPPQDLTQSSWQVRD 1345

  Fly  2696 ---KSE-CFKVEKGLL-------------SF-------GWGRWSELLELG-------------QF 2723
               ||| .||....|.             ||       |..|.:.|..:|             :|
 Worm  1346 LRNKSEKVFKAYSSLFMRHLCEPVVDNSDSFMDGVPREGLNRQAVLSRIGLMSILRKKVQEFEKF 1410

  Fly  2724 KRGWRDVDVEDCARIILLYCLQV----YKGDEKIKTFIWDL-----------ITPTED--GEVQK 2771
            ...|   .:.:....:|....|.    ..|..|||....|:           ||.||:  .|| |
 Worm  1411 NGEW---SMPETREKMLATAAQASVSNLPGMIKIKEEPIDIDETPMDVDQSNITKTEELASEV-K 1471

  Fly  2772 ISRD----------------HSGLHNLVPRGRNGGKSNKE------------------------- 2795
            :..:                ::.||:|........::.||
 Worm  1472 VEEEPKAPRLPYKFNICDGGYTELHSLWINEEKVARNGKEYEIWHRRHDFWLLAAVAVYGYGRYQ 1536

  Fly  2796 --------------------STGVSTPAPGSASGSN---SGNTTPAHKSSALDGSDKDSGGINAS 2837
                                .|| :.||...|...|   :.......:|..::...:.:..||..
 Worm  1537 INFQDIMNDPKFSIVNEPFKQTG-ADPATNFADVKNKFLARRFKLLEQSLVIEEQLRRAAHINKQ 1600

  Fly  2838 AVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLG-RHANKVLLRVRMLYYIQHEVIGDFVQQI 2901
            .....|..:  ..|:|:.| :.|||::..|.:.:.| |:||.:|          |:.:......:
 Worm  1601 QSPDQVGQL--AQHFSELE-HTADAHVNIARESNNGNRNANAIL----------HKCLAQLDDLL 1652

  Fly  2902 KD-NTPISELP-----IRP------------------PPTPDQVPSSWWNPICCDKSLLVGTYKH 2942
            .| .|.::.||     :||                  ...||..||....|
 Worm  1653 SDLKTDVARLPATISQVRPVTERLQMSERQILSRLVVAKDPDAAPSKPALP-------------- 1703

  Fly  2943 GCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINED------------DANSKHDDGDEVDD 2995
                       |:..|:|.:               .|::            |.|...|| :.:|.
 Worm  1704 -----------PSGPFITPL---------------FNQNFTTIQPKFPSLFDCNLSPDD-EPIDI 1741

  Fly  2996 DGTTTTKDSDSTKLTG-GDNKDSLL---DPERPSSSGKSSS 3032
            :|:.:...:::::.:. ...||..:   |.:.||:|..:.|
 Worm  1742 EGSISAAVAEASRASSIAATKDEPMDTSDKDIPSTSAAAGS 1782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	12/81 (15%)
		PTZ00121	<1419..1923	CDD:173412	109/577 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	21/66 (32%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	18/76 (24%)
		PLN03142	2029..>2606	CDD:215601	274/636 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd-3	NP_510140.1	CHDNT	97..150	CDD:462357	13/92 (14%)
		TNG2	<180..311	CDD:227367	23/134 (17%)
		PHD1_CHD_II	268..309	CDD:277006	6/40 (15%)
		PHD2_CHD_II	330..372	CDD:277007	3/41 (7%)
		CD1_tandem_CHD3-4_like	377..460	CDD:349314	27/93 (29%)
		CD2_tandem_CHD3-4_like	498..552	CDD:349309	16/59 (27%)
		PLN03142	564..>1129	CDD:215601	268/588 (46%)
		DUF1087	1199..1248	CDD:461922	13/54 (24%)
		CHDII_SANT-like	1299..1418	CDD:461920	22/121 (18%)
		CHDCT2	1512..1662	CDD:462358	25/163 (15%)