Protein Alignment kis and pqn-15

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001367558.1
• Gene: pqn-15 / 180705
• WormBaseID: WBGene00004106
• Length: 2171
• Species: Caenorhabditis elegans
• Alignment Length: 3070
• Identity: 698/3070 - (22%)
• Similarity: 1073/3070 - (34%)
• Gaps: 1055/3070 - (34%)

  Fly   203 QQQQQQSQQQARLPQ-HYPQAPGQHPLYPGVGAPTVQAGQPPTPQAYAHSPYGSPMQHQPSRGAP 266
            ||..|.:.|...:.: |..|.||.|.:        :|.|.||.            .|::..:|..
 Worm     4 QQHNQAAPQLLNVQRPHQIQPPGPHRV--------IQQGGPPM------------QQNKIPQGQS 48

  Fly   267 QHVGYGHTGLDQASAYGQHVPGGAPPGHHLSAQQQQAAQQLGAHQQQQLQSQQQQQAQ-QQQPHV 330
            |.|          :..||..|         ...|||.||.|..:..||::..|.|..| .|.|
 Worm    49 QMV----------NMQGQQGP---------QQMQQQPAQNLMMNMGQQMRPPQNQAPQMMQNP-- 92

  Fly   331 SLMQQQQLPGAGLPPPHMGMPPSYGSHHQQQQ----QQQQTQQQQQQSAPPYMSS--SKHQQAAA 389
               ||.|:...|.||..|...|..|...||.|    |..|.:.||||...|.|:|  |:||:|..
 Worm    93 ---QQSQIQMRGNPPQQMRGMPQQGPPMQQSQQPPPQMSQMRMQQQQPQQPNMNSPQSQHQRAPN 154

  Fly   390 QLN-----SSPQYRAPFPQLSPQMSPRPPTMSPHPQMSPRPVGVSPAKPPPPQQQQQQTQAQQPQ 449
            .:|     .:||.:...||...||..|.|.:||                       ||.|.||.|
 Worm   155 NMNMQQNLPNPQQQMRIPQAQNQMQQRIPQVSP-----------------------QQMQMQQQQ 196

  Fly   450 QVVSNQPSQHSIQGMVGLPS----PRPQPPTSGAGGAGAKGPAPVAAPVNTLQALEQ------MV 504
            .:  |.|..|..|...|.|.    |..||.....||    ||..:..|.:  |.:.|      |.
 Worm   197 NM--NGPPSHPHQMQQGGPQSINRPPSQPHQMQQGG----GPMSMNRPPS--QQMHQQGGPQLMN 253

  Fly   505 MPSQALGLPP----MDYPSAYRSAV--GPRMPASPQQQQQQHQQ-----WGAAHGAQHLAALQQQ 558
            .||..:|:.|    |..|.:....:  ||....:|.|||.:.||     ....:|:.|    |||
 Worm   254 RPSSQMGVQPQGGMMSRPPSQPHYIQQGPSSMNTPPQQQMRMQQIQQNNQNMNNGSPH----QQQ 314

  Fly   559 QAQ-QQQQQVQQQQQAPPQQQQQAAMLQAQQQHHQQQLSMYGQPMGQQPQTAQQQVVPPVTSQPP 622
            ..| ||.||.......|||||     ::.|||..|.   :.||..|..|...|||      .||.
 Worm   315 PLQHQQMQQNAPNMNMPPQQQ-----IRIQQQEPQM---LQGQTNGPPPPHQQQQ------QQPV 365

  Fly   623 VVA-ASQQQQQQQHQQQSLNDQLQHSINDIVGGGNSSGATGGAQNQHQQQPQLAAMSSPLHQQNL 686
            .|| .:||.|..|...:.:..|...||:            |..||. .|.||:....:|..||
 Worm   366 RVAQVAQQPQNMQIPPRQMTPQQSQSIH------------GSMQNS-PQNPQMRMNLAPPQQQ-- 415

  Fly   687 PNMHHLIQPTMETTQPTQQQQQTSQQQQQPQQPQATL-----TSPHHQQMQHQSPIHQQQQSPHH 746
             ..||..||      |.|...|:.:|..|.|||...:     ..|.||..|::|    .||.||:
 Worm   416 -QQHHQNQP------PMQGNPQSDRQMPQMQQPGRQIHPNIKRQPQHQMQQNRS----MQQGPHN 469

  Fly   747 QQHLPS--YNQSQQQFDPFANILGDNQPAASQQTMSPAHVSSPVPAQMQQQQHQTQQQPSQQVPQ 809
            .|::|.  .|..|.|.||.           |||.:.    .||.| .:..|.|||
 Worm   470 PQNIPDQMMNMQQMQQDPM-----------SQQPLQ----ESPQP-NLHLQHHQT---------- 508

  Fly   810 SQQQQVSQPQQQTQQQQPSTPSHHLSSILNETANSNDSSTLAVAANDSNNSSSNSSTNSIVNNQP 874
                    |..|:|..||         ::.:....::..|:.:   :..::..|.....:|..|
 Worm   509 --------PPMQSQMMQP---------VVTDNFEPDNDQTIRI---NGEHAIINGMQYKLVPQQ- 552

  Fly   875 TSVHDSNSQSSINSSSNNQQQLLMDNTNSHGGNSESA--QNAGVDVGLFDNNSMSSNSAAVAAVA 937
               ...|.|...|......||:      ..||:.|..  |..|
 Worm   553 ---RQQNQQKMPNQQGQPMQQV------HQGGHQEEGFQQQHG---------------------- 586

  Fly   938 SNAASAAAALLDSNSQSSNAEFEKNQSEGEGLGVVEGVIANETDLP-----QDENSVSKTQDITL 997
                       ..|:|..|.               :..:.|:.::|     |.:|.:::......
 Worm   587 -----------PPNNQGQNQ---------------QPPMQNQQNIPIQHQQQQQNMMNQPMQSNN 625

  Fly   998 STELPTIQD--DLQEKPTAEMEQTQLGQSLGDLSKSLLEEPKTVEESGEDKSQSAPGVAPPADPI 1060
            :..:..||:  :||..|..:.:|
 Worm   626 NQNMANIQNQQNLQNPPIIQQQQ------------------------------------------ 648

  Fly  1061 IPVTQPPQQQMPPIGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGA--PGMYPPYPMLHQQEIAAL 1123
                   |||:||.     .:||               .|.|.|.  |...||.|         :
 Worm   649 -------QQQIPPA-----KVAP---------------KPRYRGKKNPAQEPPPP---------I 677

  Fly  1124 QQQIQELYCMPPGHELQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLL 1188
            ||...|                             ::|:..:|.|.           |..|
 Worm   678 QQTNAE-----------------------------DLNNSMSGLPM-----------GAKG---- 698

  Fly  1189 NQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLMDISGNVAMGAANAVSSIPTT 1253
             ::.|.:|.:::.|...:.::.|  ..|....|...|.|:         |:|.|
 Worm   699 -ERKVMAPSLTTNTFHQQQQAPN--GLPPNNAGPMIQQGK---------NIAGG----------- 740

  Fly  1254 QLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDGSGKKKKPRKPRTPKDPNK 1318
             .|.:::.||.|                                      |..|:..:..:
 Worm   741 -YPPNQNKVTPG--------------------------------------KNVPKNQQQSR---- 762

  Fly  1319 PPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAG 1383
             |:....|.:....|:    ...|:..|:|..|:|.......|...     |.|:.::.:
 Worm   763 -PQQANGKVQAKSSPD----LSQPSTSKQRPPANKADMTVIRDAIV-----SHVKGSRKM----- 812

  Fly  1384 SADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRR 1448
                              :|:|.:....::.|...|.||                     ...:.
 Worm   813 ------------------TPEYIEYVCEELNRLMRELEK---------------------ADMKT 838

  Fly  1449 DRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDS 1513
            ||:..:.|                    ...||.:......|:|         .|.|.|:..|.:
 Worm   839 DRRYISVR--------------------KLLALIQEEKLTIIIP---------PRIPMPARYPPT 874

  Fly  1514 EMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSN---AGSDVEKTE 1575
            |      .|..:....:.::|...|:.|....|..|.|:        |..:||   ...|:.:.|
 Worm   875 E------ESLGDEPVDETVEDRAARYDDYMQVLANAYPL--------NTWDSNFMKIDDDIIRKE 925

  Fly  1576 PQSGAEGDAAQEVGEEKSNL---PLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYI 1637
            .....:.|........|.||   |.:..::.:......::.:.:.::........:...||...|
 Worm   926 ALHYRDQDMKNREMYLKENLHTFPEERQTKAKIEYLGLSLLDFQTELRKKVLATTVLVPPNDFLI 990

  Fly  1638 NTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESK 1702
            |.           .::|..|.|.:             .|.|...|.|..:|             :
 Worm   991 NP-----------WSIRRTKYEYL-------------QELKRHPDRAILEK-------------R 1018

  Fly  1703 KDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVK 1767
            :.:|:..       .::..:|...|..:..|.:..|..|.:..:...:...:|....||    :|
 Worm  1019 RKVTNFH-------FLQSLTKHAREFKEFHKRNMLNHTKVRKSMQQYITNENKRIAREE----MK 1072

  Fly  1768 TEEN--SKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDE--KSTDD--S 1826
            .|:|  .|.|:||:..               .:..:|||  .||..|...|.:|:  ||..|  .
 Worm  1073 NEKNRIQKLIQEDEEG---------------YRAMLDEK--KDQRLVYLLEQTDDYIKSLCDLLK 1120

  Fly  1827 NPEEAT----TEKNKESLEIEG--EKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVK 1885
            ..:.||    ..|:....|.:|  |:::||...:..:.::||     .|||.:   :::|:|:
 Worm  1121 QQQNATAGSLATKSYIRKEYDGVAEEDKVKSILDKARNDDDE-----YENKTK---MNIEDYY-- 1175

  Fly  1886 YRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSV 1950
                                                                             
 Worm  1176 ----------------------------------------------------------------- 1175

  Fly  1951 HTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWK 2015
                    ||.|               .:.|::.    ||:....
 Worm  1176 --------TTAH---------------GVREEIK----EQHFMMG-------------------- 1193

  Fly  2016 KLEKTPVYKGGN---SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY-GI 2076
                     |||   .|:|||::||.|:...:.|..|.|||||||||||||::.|:..:.|. ..
 Worm  1194 ---------GGNPSLKLKPYQIKGLEWMVSLFNNNLNGILADEMGLGKTIQTIAFITYLMEIKKT 1249

  Fly  2077 RGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPI---- 2136
            .||||||.||||:||||.||:.| .:::::.|.|               ..|:.||. |||
 Worm  1250 SGPFLVIVPLSTVPNWQNEFDKWAANVHLIAYKG---------------PKETRKVF-EPIIKSG 1298

  Fly  2137 KFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLR-QLNLEHRVLLSGTPLQN 2200
            |||||:||||.::.:...|....|:..:|||.|||||::|||.|.|. :...:.|:|::||||||
 Worm  1299 KFNVLLTTFEYVIREKALLGKLRWKYMIIDEGHRLKNQHCKLTEMLNTRFQCQRRLLITGTPLQN 1363

  Fly  2201 NISELFSLLNFLEPSQFSS----QEEFMSEFGSL-----RTEEE----VNKLQALLKPMMLRRLK 2252
            .:.||::|||||.||.|||    ::.|.:.|.:.     .|:||    :.:|..:|:|.:|||||
 Worm  1364 KLPELWALLNFLLPSIFSSCSTFEQWFNAPFATTGEKVELTQEETMLIIRRLHKVLRPFLLRRLK 1428

  Fly  2253 DDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPY 2317
            .:||..|..|.|.::..:::.:||..|:.:.:   ..|..|.|:....:|.|||:.|||.|.||:
 Worm  1429 KEVESELPDKMEFVVRCDMSALQKVLYKHMQK---GLLLDGKTNTGSKSLRNTMIHLRKLCNHPF 1490

  Fly  2318 LLNGAEEQIQ--YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLD 2380
            |....||..:  :|.:.....|       |...:||:.|:.::||||:|.|||||:|.||...:.
 Worm  1491 LFENVEESCRNFWDARFISAVD-------LYRVSGKLELLSRILPKLQATGHRVLMFFQMTSMMT 1548

  Fly  2381 ILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYD 2445
            |:||:|......:.|:||..:.:.|...:|:::.|.|:.|:|:|.|:|||||:||..||||||:|
 Worm  1549 IVEDFLAGGTIQYLRLDGSTKPDERGALLDKFNAPNSEYFLFMLSTRAGGLGLNLQTADTVIIFD 1613

  Fly  2446 SDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDG 2510
            |||||..|:|||.|.|||||:..|:::||:..|:.|.::...|..||.:|:.|:|:    |..|.
 Worm  1614 SDWNPHQDMQAQDRAHRIGQKAEVRVFRLITANSVEEKILAAARYKLNVDEKVIQA----GKFDN 1674

  Fly  2511 NNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAA 2575
            .:....::||.:.:.|....:..|::...|    |||:.||.|       ..|:...|.|
 Worm  1675 RSTGAERREILENIIKTENESEEDEEVPND----EDINDILSR-------SEEEFELFQK----- 1723

  Fly  2576 SGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPR--RRTQIKRYGHEDVMELNSEE 2638
                    :|.                  ||.|.|....::||  ...:|.|    |::....|.
 Worm  1724 --------MDQ------------------ERFENEQAQKAKPRLVGEDEIPR----DILRAADET 1758

  Fly  2639 SSNENSDEEGGIGL-----RSRRRKEKRDRAREKKGNDEYIPR---ERDALAALGLEEIQYGNWA 2695
            ...|.:.|||.:..     .|||.:.:.|.:.:...:|:::.:   |.|..:|...||   .|.|
 Worm  1759 DYIEKAKEEGRVPYLEVMPGSRRTRREVDYSADTMSDDKFLEKLFDEDDTTSARTEEE---PNPA 1820

  Fly  2696 KSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYK------GDEKIK 2754
            :.              |..|..:.|.......:|:.|:|.....|.:  :|.:      ||||.:
 Worm  1821 QP--------------GPSSVSISLESSCDTQKDIKVDDVPAPPLTF--KVPRLTIKLGGDEKKR 1869

  Fly  2755 TFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSA------------ 2807
            ..... .:.::|..::|..:.....|   |:.:...|..::....||.:....
 Worm  1870 KHNRS-ESDSDDNSLKKEKKHRKEDH---PKEKEKEKKKEKEQEKSTDSEKDLKRKIEAPIEKIR 1930

  Fly  2808 ---SGSNSG-----NTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKY-DADAY 2863
               ||..|.     |..|..|.....|..::....:.|         .|.:...||:|: |:|..
 Worm  1931 IKFSGEPSEKYRKINEEPPKKEHRDKGRKEEKSHKHRS---------DDDDSSPKKKKHRDSDES 1986

  Fly  2864 LEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNP 2928
            .|...|||                  :|:  .|...::::.:|:|   :....:|.::
 Worm  1987 SEKKKKKH------------------KHD--SDSALKLREGSPLS---VDKEKSPMKI------- 2021

  Fly  2929 ICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINED------------ 2981
                                            .:|.|...     .||..|||
 Worm  2022 --------------------------------RIGQGQPS-----ISLAANEDKNHPPIKLKLNV 2049

  Fly  2982 --DANSKHDDGDEVDDDGTTTTKDSDSTK---LTGGDNKDSLLDPERPSSSGKSSSENASGGNDK 3041
              :..|:..||.:.|.......|:.|..|   ...|..|:...|.::.....|.|.|      |:
 Worm  2050 KFNMPSQETDGSKKDKKEPHKEKEKDKEKEKEEDKGKEKEKHKDKDKDKEHKKKSRE------DE 2108

  Fly  3042 TESENDATTVSE--SSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVS 3104
            ||.|..|...::  ...|.|              |:|......:||..:..|..|...:..:..|
 Worm  2109 TEEERRARKEAKRLKRQKEE--------------QEDDAKLQEKLARKAAKKEQKRLEKEKSESS 2159

  Fly  3105 CDPADSSSPEAAGKA 3119
            ....:.|   |||.|
 Worm  2160 TGTVNLS---AAGSA 2171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830	95/339 (28%)
		Med15	<1056..>1265	CDD:312941	36/210 (17%)
		PRK12678	1319..>1500	CDD:237171	24/180 (13%)
		PTZ00121	<1419..1923	CDD:173412	86/521 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	7/66 (11%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	6/57 (11%)
		PLN03142	2029..>2606	CDD:215601	221/598 (37%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
pqn-15	NP_001367558.1	Med15	<1..>288	CDD:312941	100/358 (28%)
		Med15	<372..>592	CDD:312941	74/334 (22%)
		HSA	1011..1083	CDD:214727	16/95 (17%)
		PLN03142	1062..>1726	CDD:215601	265/869 (30%)
		SnAC	1727..1799	CDD:464219	19/75 (25%)