Protein Alignment kis and swsn-4

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_502082.1
• Gene: swsn-4 / 178015
• WormBaseID: WBGene00004204
• Length: 1474
• Species: Caenorhabditis elegans
• Alignment Length: 1803
• Identity: 423/1803 - (23%)
• Similarity: 720/1803 - (39%)
• Gaps: 490/1803 - (27%)

  Fly  1387 GEAETTSGGTGVDGESPDYDDIPVSKI--------PRGSNEDEKEAEA-------GDETVDSVP- 1435
            ||......|.|..|:     ::.:||:        .:|...|.:.|:|       .....|:||
 Worm    19 GEVVAQQAGDGAQGQ-----ELTISKLENAITSMEEQGLQNDHRHAKAVLLKQKLQSGLPDAVPG 78

  Fly  1436 -DSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDD 1499
             ::.|:...||::.::.|:...:.|.....|...|     :|.|.|:..|.....::||
 Worm    79 QENGGNQQITPAQLNQLRAQVSAYRLLARNEQVPA-----NLIADAVMLRPKVTTLLPE------ 132

  Fly  1500 TLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASN 1564
                  |...|.::|          |.::..|  |:|..|:..:         .:..:|    :.
 Worm   133 ------PYEYPGEAE----------NGEKLPY--DLMKIFNLHQ---------IRCNRP----TT 166

  Fly  1565 SNAGSDVEKTEPQSGAEGDAAQEVG---EEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANA 1626
            .:..|.::........|......:|   :..:|||.|....::..:.....|.:...:.|...:.
 Worm   167 ISVPSGIDPVGMLKQRENMIQNRIGLRMKLLNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSE 231

  Fly  1627 AMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELI--------LDKPKEKAPEPKQDEEKSELDE 1683
            .|:.......:.|....       .|.|..||:.:        |:|.::...|.|:.::.::|.:
 Worm   232 VMACLKRDTTLETALNP-------YAYRRTKRQSLREARVTEKLEKQQKMEQERKRRQKHTDLMQ 289

  Fly  1684 ATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDD 1748
            |...          .|:..|:...:...|:..|...|.:..::...:.|| ||...:|.:|:
 Worm   290 AIIQ----------HGKEFKEYHRNNLLKMAKSRKAVMTYHQNNERERKK-DEIRNEKLRMQ--- 340

  Fly  1749 EVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVS 1813
                                    |.::||:.......|..|:...|....:.||..:...|.|.
 Worm   341 ------------------------KLMQEDEEGYRALLDEKKDQRLVYLLQQTDEYVDSLCSLVR 381

  Fly  1814 KAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKT-EADMENKPEPVFI 1877
            :.:.:::|             |.||..:||...:..:|....|::.:..|. ..|...|.|.:
 Worm   382 QHQNTEKK-------------KKKEDKKIEKGNQMDEEARVHVRERSTGKALTGDQAPKTEEI-- 431

  Fly  1878 DVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDE--PFNQDFT 1940
               |:::          |...|.|::..|                ||:..|..|:|  |...:..
 Worm   432 ---EFWL----------ETHPEYEIVPRD----------------QLSDDEEEEEEEAPVEPEEE 467

  Fly  1941 EVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKS 2005
            :.|:...|.        |.||..::..|:...||   |.::.......:.|...:||.:
 Worm   468 KDDQYAGMD--------EETKAKMILEKARNEED---EYDQKTKKQMADYYATAHKIKE------ 515

  Fly  2006 KKRPHPELWKKLEKTPVYKGGNS----LRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLT 2066
                      |:.|.....||..    |:|||::||.|:...:.|..|.|||||||||||||:::
 Worm   516 ----------KVVKQHTTMGGGDPNLLLKPYQIKGLEWMVSLYNNNLNGILADEMGLGKTIQTIS 570

  Fly  2067 FVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESG 2129
            .|..:.|. ...||:|||.||||:.|||.||..|. .:..::|.|:..:::.::          |
 Worm   571 LVTYLMEVKQNNGPYLVIVPLSTLSNWQNEFAKWAPSVTTIIYKGTKDARRRVE----------G 625

  Fly  2130 KVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKL---LEGLRQLNLEHRV 2191
            ::.|.  .||||:||:|.::.:...|....|:..:|||.|||||.||||   |.|.  .:.:||:
 Worm   626 QIRKG--AFNVLMTTYEYVIKEKALLGKIRWKYMIIDEGHRLKNHNCKLTLMLNGF--FHAQHRL 686

  Fly  2192 LLSGTPLQNNISELFSLLNFLEPSQFSS----QEEFMSEFGSLRTEEEVN---------KLQALL 2243
            ||:||||||.:.||::|||||.||.|||    ::.|.:.|.:...:.|:|         :|..:|
 Worm   687 LLTGTPLQNKLPELWALLNFLLPSIFSSCGTFEQWFNAPFATTGEKVELNQEETMLIIRRLHKVL 751

  Fly  2244 KPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMME 2308
            :|.:|||||.:||..|..|.|.:|:.:.:.:||..||.:.:   ..|.....|:...:||||::.
 Worm   752 RPFLLRRLKKEVESQLPDKTEYVIKCDQSALQKVIYRHMQK---GLLLDAKMSSGARSLMNTVVH 813

  Fly  2309 LRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYK-------NLILSAGKMVLIDKLLPKLKANG 2366
            |||.|.||:|....|:..:            :|:|       :|:..|||:.|:|::||||||.|
 Worm   814 LRKLCNHPFLFPNIEDSCR------------AYWKVNEVNGTDLMRVAGKLELLDRILPKLKATG 866

  Fly  2367 HRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGL 2431
            ||:|:|.||...::|.||:|.:|:|.:.|:||..:.:.|.:.:.:::.|.||.|:|:|.|:||||
 Worm   867 HRILMFFQMTSMMNIFEDFLNFRRYTYLRLDGSTKPDERGDLLTQFNAPNSDLFLFMLSTRAGGL 931

  Fly  2432 GINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDK 2496
            |:||..||||||:||||||..|:|||.|.|||||:|.|::.||:..|:.|.::...|..||.:|:
 Worm   932 GLNLQTADTVIIFDSDWNPHQDMQAQDRAHRIGQKKEVRVLRLITANSVEEKILAAARYKLNVDE 996

  Fly  2497 AVLQSMN-TQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITM 2560
            .|:|:.. .|.|.....||:.::.|:      |.|...:::...|   :|.::       |::..
 Worm   997 KVIQAGKFDQRSTGAERKQMLEQIIQ------ADGEEEEEEEVPD---DETVN-------QMVAR 1045

  Fly  2561 ESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKR 2625
            ..|:.:.|                          :.:|||    .|.|..:.:..:||...:
 Worm  1046 SEEEFNIF--------------------------QSMDID----RRREEANQLHRKPRLLEE--- 1077

  Fly  2626 YGHE---DVMELNSEESSNENSDEEGGIGL----RSRRRKEKRDRAREKKGNDEYIPRERDALAA 2683
              ||   |:::|:.:....|.:.|||...:    ..|||:.:.|.:.:...:::::.:
 Worm  1078 --HEIPDDILKLSFDYEEMERAREEGREVVDQTPNQRRRRREVDYSSDLLSDEQFMKQ------- 1133

  Fly  2684 LGLEEIQ-YGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVY 2747
              :||:: ..|.|.:|..|                    |.||....:|..|.:...::...:..
 Worm  1134 --VEEVEDENNQAVAERKK--------------------QRKRKMAGLDENDDSMDDVVLQHKKK 1176

  Fly  2748 KGD----EKIKTFIWDLIT--PTEDGEV------------------QKISR--DHSGLHNLVPRG 2786
            |.|    |||...: |:|.  ..||||:                  |.||:  |...::..:..|
 Worm  1177 KTDPELAEKINEML-DVILEYKNEDGELIADVFQTLPTRKELPDYYQVISKPMDFDRINKKIETG 1240

  Fly  2787 R----------------NGGKSNKESTGV-------------------STPAPGSASGSNSGNTT 2816
            |                |....|:|.:.:                   :.|.|..........:|
 Worm  1241 RYTVMEELNDDMNLLVNNAQTYNEEGSEIYVSSETIGKLWKEQYDKFMNPPKPVEEPVKKKEPST 1305

  Fly  2817 PAHKSSALDGSDKDS-GGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVL 2880
            |:..||....|...| ..:..:..|.|...:....|........|..:.:....:..|..|
 Worm  1306 PSTSSSRPSTSGTPSVSDLQRTQQATAQQMLMLMTHMQSLPPAQAQQFQQALMTQTGGNQA---- 1366

  Fly  2881 LRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCE 2945
               .||.|:|..::   .|:.:.:|.:         ||.:
 Worm  1367 ---LMLQYMQSAML---AQRAQASTKV---------TPKK------------------------- 1391

  Fly  2946 MYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDS--DSTK 3008
                                   |:...||..:..::|..        ||:.:|::..:  ...|
 Worm  1392 -----------------------DEKKETSSSVKTEEAKK--------DDEPSTSSASAPPPKKK 1425

  Fly  3009 LTGGDNKDSLLDPE---------RPSSSGKSSSENASGGNDKTESEND 3047
            ....|::|.:.:.|         .|:||.:.|.......|:..|.|:|
 Worm  1426 KESEDSEDPMEEDEEEEIIGQKKEPASSRRKSRPTRRFSNEDEEEEDD 1473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	27/129 (21%)
		PTZ00121	<1419..1923	CDD:173412	87/524 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	11/67 (16%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/57 (18%)
		PLN03142	2029..>2606	CDD:215601	218/602 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
swsn-4	NP_502082.1	QLQ	88..116	CDD:462622	6/32 (19%)
		HSA	272..344	CDD:214727	16/109 (15%)
		BRK	403..446	CDD:462196	10/57 (18%)
		PLN03142	472..1288	CDD:215601	280/952 (29%)