Protein Alignment kis and Hells

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_032260.2
• Gene: Hells / 15201
• MGIID: 106209
• Length: 821
• Species: Mus musculus
• Alignment Length: 910
• Identity: 286/910 - (31%)
• Similarity: 443/910 - (48%)
• Gaps: 226/910 - (24%)

  Fly  1760 EEQSETVKTEENSKAIEE-----DKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSD 1819
            |||.|....|:..|.:||     |:.||.:   ..:..:.:|||..:..|     ..::|.|
Mouse    18 EEQLEAAGLEKERKMLEEAQKSWDRESTEI---RYRRLQHLLEKSNIYSK-----FLLTKME--- 71

  Fly  1820 EKSTDDSNPEEATTEKNKESLEI-EGEKERVKEGEESV-KKENDEKTEADMENKPEPVFIDVEEY 1882
            ::..::...:| ..||.|.||:: ||:......||:.| ||:...:.|
Mouse    72 QQQLEEQKKKE-KLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDE----------------- 118

  Fly  1883 FVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLD 1947
                   ||...|..::||:|.    ||.|                       ::|
Mouse   119 -------SYNISEVMSKEEILS----VAKK-----------------------HKD--------- 140

  Fly  1948 MSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDN-----DKIEQYLRFNK----IPQRSEW 2003
               :.||:|..|:.             |..:::::.|:     |::.|.:|.|.    .|.|
Mouse   141 ---NEDESSSTTSL-------------CVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVR--- 186

  Fly  2004 KSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFV 2068
            |...:|.|      .:.|.:..|..:|.||:||:.||:..|.|..|.|||||||||||:|.:..:
Mouse   187 KCNGQPVP------FQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATI 245

  Fly  2069 HSVYEYGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVL 2132
            ..:.:.|:.|||||..||||:|||..||:.:| ::..::|||:...::.:  .:..:|.: |.:.
Mouse   246 ALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKL--VKNIHKRQ-GTLQ 307

  Fly  2133 KEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTP 2197
            ..|    |::|:||:.:.|...|:...|:..::||.||:||..|:|:..|::.|.::::||:|||
Mouse   308 IHP----VVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTP 368

  Fly  2198 LQNNISELFSLLNFLEPSQFSSQEEFMSEFG--SL-----------RTEEEVNKLQALLKPMMLR 2249
            ||||:|||:||||||.|..|...:.|.|.|.  ||           |.:..::.|..:|.|.:||
Mouse   369 LQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLR 433

  Fly  2250 RLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQ----------------------------- 2285
            |||.||...:.||.|.::...|.|.|:.:|..|:.:
Mouse   434 RLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKS 498

  Fly  2286 -NFSFL--------------------KKGTTSANIP-------NLMNTMMELRKCCIHPYLLNGA 2322
             |:|.|                    ::.....|||       .|.|.||.|||||.|||::...
Mouse   499 INYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYP 563

  Fly  2323 EEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLV 2387
            .:.:..:||..         :.|:.::||.:::|::||:||..||:||:||||...||||.||..
Mouse   564 IDPVTQEFKID---------EELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCH 619

  Fly  2388 YRKYPFERIDGRIRGNLRQEAIDRYS-KPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQ 2451
            .|.:.|.|:||.:..:.|::.|  || ....|.|:||:.|:||||||||||||||||||||||||
Mouse   620 LRNFIFSRLDGSMSYSEREKNI--YSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQ 682

  Fly  2452 NDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQ-- 2514
            :|||||.|||||||.|.|.:|||:..||.::::.::|:.|..|:|.::...:.:|.:.|.::.
Mouse   683 SDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKN 747

  Fly  2515 -LSKKEIEDLLK--------KGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESE---KGST 2567
             |..||:.:|||        ||:...|:.|         ||::.:|.|...:..|::.   ||.|
Mouse   748 FLDAKELMELLKSRDYEREVKGSREKVISD---------EDLELLLDRSDLIDQMKASRPIKGKT 803

  Fly  2568  2567
            Mouse   804  803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	40/169 (24%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	15/67 (22%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/62 (16%)
		PLN03142	2029..>2606	CDD:215601	228/625 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..120		14/66 (21%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	94/239 (39%)
		PLN03142	204..>781	CDD:215601	222/603 (37%)
		helicase domain I	226..238		10/11 (91%)
		helicase domain Ia	258..266		5/7 (71%)
		helicase domain II	334..341		2/6 (33%)
		helicase domain III	363..370		5/6 (83%)
		helicase domain IV	429..439		6/9 (67%)
		helicase domain IVa	547..559		9/11 (82%)
		'helicase domain IVb	602..609		5/6 (83%)
		helicase domain V	655..668		9/12 (75%)
		helicase domain VI	686..693		5/6 (83%)