Protein Alignment kis and Smarcad1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_031984.1
• Gene: Smarcad1 / 13990
• MGIID: 95453
• Length: 1021
• Species: Mus musculus
• Alignment Length: 1137
• Identity: 310/1137 - (27%)
• Similarity: 484/1137 - (42%)
• Gaps: 277/1137 - (24%)

  Fly  1538 RFSDDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQ 1602
            ||..::.|.:..:|     :.:...|.:...|.:..:..:..|||:.:      ::|.|..:.::
Mouse     8 RFRFEKRSKIEEAP-----EAAPQPSQARPSSPISLSAEEENAEGEGS------RANTPDSDVTE 61

  Fly  1603 LEASSSTSAVAEKERQISTDAANAAMSSKPN------YVYINTGDED-----SMVVQLVLAMRMG 1656
            ....||.....:.||:       |::|...|      |:.:::..||     |..||   ..:..
Mouse    62 KTEDSSVPEPPDNERK-------ASLSCFQNQRAIQEYIDLSSDTEDVSPNCSSTVQ---EKKFS 116

  Fly  1657 KRELILDKPKEKAPEPKQDEEKSELDEAT--TDKPE----------GDEKFKTEGESKKDLTDSE 1709
            |..:|:      ..||.:|||..:|...|  .|..|          .|.|.:|..|.....:||:
Mouse   117 KDTVII------VSEPSEDEESHDLPSVTRRNDSSELEDLSELEDLKDAKLQTLKELFPQRSDSD 175

  Fly  1710 ETKLESSAMEVDS-----------------KEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKES 1757
            ..||..|...:|.                 |.:.    |..|:||:.:      ||:..|..:..
Mouse   176 LLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKL----SSSSEEDDVN------DDQSVKQPRGD 230

  Fly  1758 KPEEQSETVKTEENSKAIEEDKSSTVL-------------TADHAKEPE----TVLEKMEVDEKA 1805
            :.||.:|:.:...|    .|.:.|.||             ..:..||.|    ..||.::|..:.
Mouse   231 RGEESNESAEASSN----WEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAED 291

  Fly  1806 NDDQSA-VSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADME 1869
            .|.|.| .|:.....|.:.:.:..:.||..|.|:.:.::.:....|:.:::|  .|.:|...|.|
Mouse   292 QDVQCASQSEVTNGKEVARNQNYSKNATKIKMKQKISVKPQNGFNKKRKKNV--FNPKKAVEDSE 354

  Fly  1870 -NKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRF---------------QQ 1918
             :........::|        .|..|| ...|:..||      ||..|               .|
Mouse   355 YDSGSDAGSSLDE--------DYSSCE-EVMEDGYKG------KILHFLQVSSIAELTLIPKCSQ 404

  Fly  1919 KQSQQLNIFENIEDEPFNQ---DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELE 1980
            |::|::.     |..|||.   .||::.::..:|                       ||..|..:
Mouse   405 KKAQKIT-----ELRPFNNWEALFTKMSKINGLS-----------------------EDLIWNCK 441

  Fly  1981 ----------------EDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSL 2029
                            ||:.|...:|.....  .....|   .|..|.|..:         ..||
Mouse   442 TVIQERDVVIRLMNKCEDISNKLTKQVTMLT--GNGGGW---NREQPSLLNQ---------SLSL 492

  Fly  2030 RPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQR 2094
            :|||..|||||.....:..|.|||||||||||||::.|:..:::.|.:||.|::.|.|||.||.|
Mouse   493 KPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLR 557

  Fly  2095 EFEGW-TDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAF 2158
            |...| ..:||:.|:||...::.|: :..:.|.|.         :||::||:...::...|...|
Mouse   558 EVNLWCPSLNVLCYYGSQEERKQIR-FNIHNKYED---------YNVIVTTYNCAISSSDDRSLF 612

  Fly  2159 NWRL----CVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSS 2219
            . ||    .:.||.|.|||......:.|..:|..:|:||:|||:|||:.||.|||||:.|..|||
Mouse   613 R-RLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSS 676

  Fly  2220 QEEFMSEFGSLRT----------EEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNI 2274
            ....:....|.:|          :|.:...:.::||.:|||:|::|.|.|.||::.|....::..
Mouse   677 STSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDRIELCAMSEK 741

  Fly  2275 QKKYYRGI---LEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYL------------------ 2318
            |::.|.|:   |:::.:.|:|.|      .:.|.||:|||...||.|
Mouse   742 QEQLYSGLFNRLKKSINNLEKNT------EMCNVMMQLRKMANHPLLHRQYYTPEKLKEMSQLML 800

  Fly  2319 -----------LNGAEEQIQYDF-------KSQHGEDPESYY--KNLILSAGKMVLIDKLLPKLK 2363
                       |...:.::..||       :.||   ..||.  .:|||.:||...:..:|.:||
Mouse   801 KEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQH---INSYQLDMDLILDSGKFRALGCILSELK 862

  Fly  2364 ANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKA 2428
            ..|.||::|||....|||||..|.:.::.:.|:||:.:.:.|...||.:: ...|.|||||.|||
Mouse   863 QKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFN-TDMDIFVFLLSTKA 926

  Fly  2429 GGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLG 2493
            ||||||||:|:.||::|.|.||.||.||:.||||:||.|.|.:.:|:.:.|.|..|......||.
Mouse   927 GGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLK 991

  Fly  2494 LDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLK 2525
            |:    |.|.|....|..:   ...:|..|||
Mouse   992 LE----QDMTTVDEADEGS---MPADIATLLK 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	94/458 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	15/82 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/76 (13%)
		PLN03142	2029..>2606	CDD:215601	196/553 (35%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Smarcad1	NP_031984.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		16/91 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..151		9/26 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..246		12/58 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..366		6/38 (16%)
		HepA	<480..992	CDD:440319	191/541 (35%)
		DEGH box	623..626		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	716..733		8/16 (50%)
		DEAD box	1000..1003		0/2 (0%)