Protein Alignment kis and lds

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_061511887.1
• Gene: lds / 1280703
• VectorBaseID: AGAMI1_003319
• Length: 1197
• Species: Anopheles gambiae
• Alignment Length: 1253
• Identity: 266/1253 - (21%)
• Similarity: 463/1253 - (36%)
• Gaps: 364/1253 - (29%)

  Fly  1584 AAQEVGEEKSNLPLDESSQLEASSSTSAVAE----KERQISTDAANAAMSSKPNYVYINTGDEDS 1644
            :||.:..|.|  ..::|.|.:.|.||...||    :|....::|.|::.:|.||...:.:.:|:.
Mosquito     2 SAQNIFVEDS--AEEDSFQDQQSFSTHREAESIVIEETDSDSEAMNSSAASSPNSSSVVSSEEEE 64

  Fly  1645 MVVQLVLAMRMGKRELI---LDKPKEKAPEPKQDEEKSE-LDEA------------TTDKPEGDE 1693
            ....:|..|:  ||:.:   |.....::....:||.|.| .||:            |:|..:|:|
Mosquito    65 EEESVVRQMK--KRQSVRMSLHPIHAESESSDEDETKEEGQDESNDVSAAAGKLLLTSDDEDGEE 127

  Fly  1694 -----------KFKTEGESKKDLTDSEET---------------------KLESSAMEVDSKEES 1726
                       :....|.:..:.|:.|:|                     |...:.:..|.:||.
Mosquito   128 EVERRAYSPATRMSIHGIAPAETTEDEDTPTGGGSDGGSDDDEEIIAVPRKQRKNLIISDDEEEE 192

  Fly  1727 EPDDSKKSDEDNKD--------------------KDKMEVDDEVGKSDKESKPEEQSETVKTEEN 1771
            :...|:.:...|.|                    :::..|:.::..|.|..:.|..||.|...|.
Mosquito   193 DRKRSRNNMSFNADGTPRPNPKRRNLSTTSPLEQEEQESVNTKLSSSLKSDEMERSSEQVDEREQ 257

  Fly  1772 SK----------------AIEEDKSSTVL-----------------TADHA----KEPETVLEKM 1799
            |:                :|.|..|||.:                 :|::|    ||.....||:
Mosquito   258 SRGELSFIGGRHSISMRASIGEKLSSTHIGEMDPLGPMANVETVFASAENAQSPIKEGAHSSEKV 322

  Fly  1800 EVDEKANDDQSAVSKAEGSDE---KSTDDSNPEEATTEKNKESLEIEGEKER-VKEGEESVKKEN 1860
            :.:..|.||.|:|...|.|:|   .|:.|.:.|....|:.:.|::::...:. |:....|..:..
Mosquito   323 DSNSPAKDDSSSVRLIEKSEEILCLSSSDDDGEVTFVEETRPSIDVKTRPQALVQPTITSFVRSQ 387

  Fly  1861 DEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRV----AAKIRRFQQKQS 1921
            |...:...        :...||..|.|..:.|..:....:.:::...::    |..:||..:.:|
Mosquito   388 DTAQQRQR--------VSQSEYDAKVRRMAELKSQVVMIDNVMRNSAKLPDKGAGLVRRLAEVKS 444

  Fly  1922 QQLNIFENIE---DEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSL--PYED------- 1974
            |...:.::||   ..|.......:.|..|.::...:|......|  :.|.::  ..:|
Mosquito   445 QIFELSKDIEMTRATPSKGIKKTIQRNFDENISGGDTKPRPADH--ISWDTIKRATDDIQPRHTG 507

  Fly  1975 ----CTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLE 2035
                .|:|.::.:..|::|   ..:|..:....:......|:| .|:|          |..:|..
Mosquito   508 KQGIATFENQKLLTMDRLE---TLHKSIETCPSEDTLADPPKL-LKIE----------LMDHQRH 558

  Fly  2036 GLNWLKFSWYNT---HNCILADEMGLGKTIQSLTFVHSVYEYG---------------------- 2075
            .|.|:  .|..|   ...||||:||||||:..::.|....|..
Mosquito   559 ALAWM--LWRETQKPRGGILADDMGLGKTLSMISLVLKSAELDPDGEQLERASESEDDEGDEENH 621

  Fly  2076 --------------IRGPFLVIAPLSTIPNWQREFEGWTDMN---VVVYHGSVTSKQMIQDYEYY 2123
                          ..|..|::.|.|.:..|:.|.......|   |.|:||
Mosquito   622 NPNGGWKSKGRKDYYAGGTLIVCPASLMRQWEGEITNRVKRNSLAVCVHHG-------------- 672

  Fly  2124 YKTESGKVLKEPIKFNVLITTFEMIVTD--------YMDLKAFNWRLCVIDEAHRLKNRNCKLLE 2180
              |:.....:...|::|:|||:.::..:        ...:...||...::||||.::|....:.|
Mosquito   673 --TQRESKPRHLAKYDVVITTYNLVSRESRAGTARGASGVYGVNWERIILDEAHVIRNHKSAMSE 735

  Fly  2181 GLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKP 2245
            ....|...:|.||:|||:||...::::|:.||..:.|:....:.....: :|.....:|..::|.
Mosquito   736 ACCGLKGRYRWLLTGTPIQNKEMDVYALMKFLRCTPFNDLVHWKRWIDN-KTAGGAMRLNTIMKS 799

  Fly  2246 MMLRRLKDDVEK-----SLAPKEETIIEVELTNIQKKYYRGILEQ-------------------N 2286
            :||||.|..:::     ||..|...||||:|...:...|:.:|..                   |
Mosquito   800 IMLRRTKKQLQERGALTSLPSKTIEIIEVQLEKDEMNVYQKVLMYSKHLFAQFLHQRAEKEHAIN 864

  Fly  2287 FSF-------------------------LK-----KGTTSANIPNLMNTMMELRKCCIHPYLL-- 2319
            :.|                         ||     |..:......::..::.||:.|.||.|:
Mosquito   865 YGFGGARPTFSQRAHGGANQAFDKVHQKLKSMHAAKDGSEVKQHQILVLLLRLRQVCCHPGLIYE 929

  Fly  2320 -------------NGAEEQIQY----------------DFKSQH--------GEDPESYYKNLIL 2347
                         .|.||:..:                |..:.|        |.|......:|.|
Mosquito   930 MLSDDDQSNLDMTGGGEEEGSFGAEVDLLGALNKLKLSDVLADHEAKVAANGGADGSKQELSLNL 994

  Fly  2348 S------------AGKMVL--------------IDK----LLPKLKANGHRVLIFSQMVRCLDIL 2382
            |            |.|::|              |:|    |..|:.....:.:|.||....||||
Mosquito   995 SDQFDRPEAMAKAASKVMLKSNPIFRIERPSSKIEKTMQLLEEKIFHTDDKAIIVSQWTSMLDIL 1059

  Fly  2383 EDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSD 2447
            ..:|..|..||..:.|:::...|.:.:..::||.....|.||...|||:|:||..|:.:::.|..
Mosquito  1060 ATHLSERNVPFVSLTGKVQVKFRNDIVLDFNKPSGKSKVMLLSLTAGGVGLNLVGANHLLLLDPH 1124

  Fly  2448 WNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNN 2512
            ||||.:.|||.|.:|:||.|.|.|::.:|..|.|:::......|||:...||.....:|
Mosquito  1125 WNPQLEAQAQDRVYRVGQTKPVYIWKFMCAETVEQKIQALQEHKLGIADGVLTGTVNKG------ 1183

  Fly  2513 KQLSKKEIEDLLKKGAYG 2530
               ||..|:||  |..:|
Mosquito  1184 ---SKLTIDDL--KSLFG 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	89/455 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	10/70 (14%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/70 (14%)
		PLN03142	2029..>2606	CDD:215601	158/675 (23%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
lds	XP_061511887.1	None