Protein Alignment kis and Etl1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_061519079.1
• Gene: Etl1 / 1279402
• VectorBaseID: AGAMI1_014601
• Length: 868
• Species: Anopheles gambiae
• Alignment Length: 927
• Identity: 300/927 - (32%)
• Similarity: 431/927 - (46%)
• Gaps: 216/927 - (23%)

  Fly  1726 SEPDDSKKSDEDNKDKDKMEVDDEVGKSDKES-------KPEEQSETVKTEENSKAIEEDKSSTV 1783
            :|..|.|.|....:.:.:|     :|.||.||       ||.........:||...    ||...
Mosquito    18 NEAGDGKLSLIPGRKRIQM-----MGDSDSESDASTTPIKPVPIPVVGAVKENGAT----KSPAA 73

  Fly  1784 LTADHAKEPETVLEK-----MEVDEKANDDQSAVSKAEGSDEKSTDD----------------SN 1827
            ||   .||.|..|:|     ||||  |...||::...|...:|:.::                ..
Mosquito    74 LT---IKEKELRLQKVRQACMEVD--AMLLQSSLVSNEWDVDKAIEELKKTAVKRKIIVSPSPVK 133

  Fly  1828 PEEATTEKN-KESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSY 1891
            |..|.|..| ||..:.:.:|.||:|...|     |::::.|.:...|.||...|:  ......||
Mosquito   134 PATAETATNGKEKNQQQAKKRRVQEPNRS-----DDESDVDSDRPAEQVFDSDED--SDGHGGSY 191

  Fly  1892 LHCEWRTE-----EELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLD-MSV 1950
            .|.:...|     |.|..........::....|:.:.|     :|..||......||::.. .|:
Mosquito   192 SHGKLSNERKNVLEFLNTAGLNEMICVKTLSMKKIELL-----LEQRPFKDWSNLVDKLKSHRSL 251

  Fly  1951 HTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWK 2015
            .||..:  .|:.||.:.|::                              :...||.:   ::.|
Mosquito   252 QTDILN--YTQEYLTRRKNI------------------------------AAMMSKCK---KITK 281

  Fly  2016 KLEK-------TPVYKGGN-----SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFV 2068
            |||:       |.|.:.||     .|..|||.|||||...:.:..|.|||||||||||||.:.|:
Mosquito   282 KLEEAIASGSGTLVEQPGNIADGFKLAEYQLVGLNWLTIMYRHKMNAILADEMGLGKTIQIIAFL 346

  Fly  2069 HSVYEYGIR-GPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQ-DYEYYYKTESGK 2130
            ..:.|...: .|.||:.|.||:.||::|...| .::.::.|:||...::||: |:
Mosquito   347 AWLKENNHQERPNLVVVPSSTMDNWEQELVKWCPELVILKYYGSQAERRMIRVDW---------- 401

  Fly  2131 VLKEPI-KFNVLITTFEMIVTDYMDLKAFNWRL-----CVIDEAHRLKNRNCKLLEGLRQLNLEH 2189
             .|..| :.:|::||:.|:.....:.|.  ||:     .|.||||.|||.:.:..:.|.::|.::
Mosquito   402 -AKNGINEVDVVLTTYHMMGASGEEKKM--WRVTQFDYVVFDEAHMLKNVHSQRYQNLIRINAKY 463

  Fly  2190 RVLLSGTPLQNNISELFSLLNFLEPSQFSSQ-EEFMSEF-GSLRT-----EEE--------VNKL 2239
            |:||:|||||||:.||.|||.|:.|....|: |:..:.| |.::|     |||        :::.
Mosquito   464 RILLTGTPLQNNLLELMSLLCFVMPKLIGSKVEDIKTLFQGKVKTNKGEGEEELSSFEKNQIDRA 528

  Fly  2240 QALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILE--QNFSFLKKGTTSANIPNL 2302
            :.::||.:|||||.||...|.||:|.:::..:.:.|::.|..|:.  ||.:...|..|..   :.
Mosquito   529 KLIMKPFVLRRLKKDVLAFLPPKKEVVLKTSMIDSQQEKYNEIVNEYQNATGKVKDYTEI---SG 590

  Fly  2303 MNTMMELRKCCIHPYLL----------------------NGAEE-----QIQY--DFKSQHGED- 2337
            |:.||:|||...||.||                      .|.:|     .|.|  |||.....|
Mosquito   591 MSIMMDLRKLANHPLLLRYYYSDDDVRNIARKLATDPDYKGTKEDDIFYDIAYLSDFKLYEMRDK 655

  Fly  2338 ---------PESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPF 2393
                     ||    .||.|:||...:|:||||:|..|||||||||....|||:|.||..||:.|
Mosquito   656 YTTLYDLQLPE----KLITSSGKFRQLDELLPKMKEEGHRVLIFSQFTMMLDIMERYLKIRKHGF 716

  Fly  2394 ERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQA 2458
            .|:||......|||.||:|:: ..|.|:|||.||||||||||||||||||:|.|:||.||.||:.
Mosquito   717 LRLDGSTAVTERQELIDQYTQ-DPDLFIFLLSTKAGGLGINLTAADTVIIHDIDFNPYNDKQAED 780

  Fly  2459 RCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQ--------- 2514
            |.||:||:|.|.||:|:...|.|..|...|..||.|:|.|.:       :||.|..
Mosquito   781 RAHRMGQKKPVTIYKLISEGTIEEGMLMIAQQKLQLEKDVTE-------QDGKNPMDDHKCMVGL 838

  Fly  2515 ------LSKKEIEDLLK 2525
                  |.:|:.|.:||
Mosquito   839 LTMALGLDEKKAETILK 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	56/230 (24%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/71 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	9/58 (16%)
		PLN03142	2029..>2606	CDD:215601	221/577 (38%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Etl1	XP_061519079.1	None