DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kis and Chd1

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_031716.2 Gene:Chd1 / 12648 MGIID:88393 Length:1711 Species:Mus musculus


Alignment Length:1819 Identity:509/1819 - (27%)
Similarity:804/1819 - (44%) Gaps:415/1819 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1540 SDDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGD-AAQEVGEEKSNLPLDESSQL 1603
            ||:|:....:....:......:||.|.:||       .||:..| ::.:.|...|:...|..||.
Mouse     5 SDEESVRNGSGESSQSGDDCGSASGSGSGS-------SSGSSSDGSSSQSGSSDSDSGSDSGSQS 62

  Fly  1604 EASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEK 1668
            |:.|.||    :|.::         .:||..|   .|.|.......:||:   :|..:|.|..::
Mouse    63 ESESDTS----RENKV---------QAKPPKV---DGAEFWKSSPSILAV---QRSAMLRKQPQQ 108

  Fly  1669 APEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKK 1733
            |.:.:.....|..:|.::...:.|:  .:.|..:|...| |:.::..|.    |..:|..|...:
Mouse   109 AQQQRPASSNSGSEEDSSSSEDSDD--SSSGAKRKKHND-EDWQMSGSG----SPSQSGSDSESE 166

  Fly  1734 SDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEK 1798
            .:.|....|..|.|.|.....:..||:.:|::    :|.|.|...|...:   |.:::.:.  |.
Mouse   167 EERDKSSCDGTESDYEPKNKVRSRKPQNRSKS----KNGKKILGQKKRQI---DSSEDEDD--ED 222

  Fly  1799 MEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGE--ESVKK--- 1858
            .:.|::::..|:.|:.:...||:...||:          :.||:.||.....|.|  |::::   
Mouse   223 YDNDKRSSRRQATVNVSYKEDEEMKTDSD----------DLLEVCGEDVPQPEDEEFETIERVMD 277

  Fly  1859 ------------------ENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKG 1905
                              |.|....|..|...||..|   :|.:|::.:|::|..|.|||.|.:.
Mouse   278 CRVGRKGATGATTTIYAVEADGDPNAGFERNKEPGDI---QYLIKWKGWSHIHNTWETEETLKQQ 339

  Fly  1906 DRRVAAKIRRFQQKQSQQLNIFENI--ED-EPFN--QDFTE--------VDRVLDMSVHTDETSG 1957
            :.|...|:..:::|..:.....:|.  || |.:|  |:.|:        |:|::   .|:::.|.
Mouse   340 NVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERII---AHSNQKSA 401

  Fly  1958 ETTKHYLVKWKSLPYEDCTWE---LEEDVDNDKIEQYLRFNKIPQRSEWKS----KKRPHPELWK 2015
            .....|..||:.|||.:|:||   |........|::|...|: .:.:.:|.    |:||.   :.
Mouse   402 AGLPDYYCKWQGLPYSECSWEDGALISKKFQTCIDEYFSRNQ-SKTTPFKDCKVLKQRPR---FV 462

  Fly  2016 KLEKTPVYKGGN---SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVY-EYGI 2076
            .|:|.|.|.||:   .||.|||.|||||..||...::||||||||||||||:::|::.:: |:.:
Mouse   463 ALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQL 527

  Fly  2077 RGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNV 2140
            .||||::.||||:.:||||.:.| :.||.|||.|.:.|:.||:.:|:.:..      .:.:|||:
Mouse   528 YGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWMHPQ------TKRLKFNI 586

  Fly  2141 LITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISEL 2205
            |:||:|:::.|...|...||....:||||||||.:..|.:.|......||:|::||||||::.||
Mouse   587 LLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKEL 651

  Fly  2206 FSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVE 2270
            :|||:|:.|.:|||.|:|..|.|..| |.....|...|:|.:|||:|.||||||..|.|.|:.:|
Mouse   652 WSLLHFIMPEKFSSWEDFEEEHGKGR-EYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRME 715

  Fly  2271 LTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHG 2335
            ::.:||:||:.||.:|:..|.|| :..:....:|.||||:|||.|.||:...:....|       
Mouse   716 MSALQKQYYKWILTRNYKALSKG-SKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFY------- 772

  Fly  2336 EDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRI 2400
             :.:...::||.|:||::|:||||.:|:..|:||||||||||.||||.:||.||::||:|:||.|
Mouse   773 -NKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSI 836

  Fly  2401 RGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQ 2465
            :|.||::|:|.::..||:.|.|||.|:||||||||.:||||:|:|||||||||||||||.|||||
Mouse   837 KGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQ 901

  Fly  2466 RKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNT-------QGSKDGNNKQLSKKEIEDL 2523
            :|.|.||||:.:.:.|.::.::|..|:.||..|:|.|:|       .||...::...:|:|:..:
Mouse   902 KKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAI 966

  Fly  2524 LKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKG---------STFSKASFAASGNR 2579
            ||.||.....:.:....:..|.|||.||||..   |.|:|.|         |.|..|:|:     
Mouse   967 LKFGAEELFKEPEGEEQEPQEMDIDEILKRAE---THENEPGPLSVGDELLSQFKVANFS----- 1023

  Fly  2580 SDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRR--TQIKRYGHEDVMELNSEESSNE 2642
               .:|:.|        ::::|:...:: .|:::..|.|||  .:.::...|::..|....:..:
Mouse  1024 ---NMDEDD--------IELEPERNSKN-WEEIIPEEQRRRLEEEERQKELEEIYMLPRMRNCAK 1076

  Fly  2643 NSDEEGGIGLRSRRRK---------EKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSE 2698
            .....|..|.|||.|:         .:|.|.: |:|....||||.    ..|..:.:...:.|| 
Mouse  1077 QISFNGSEGRRSRSRRYSGSDSDSISERKRPK-KRGRPRTIPREN----IKGFSDAEIRRFIKS- 1135

  Fly  2699 CFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITP 2763
             :|      .|| |....|..:.      ||.::.|                 |.:|.:..|...
Mouse  1136 -YK------KFG-GPLERLDAIA------RDAELVD-----------------KSETDLRRLGEL 1169

  Fly  2764 TEDGEVQKISRDHSGLHNLVPRGRNGGKSNK------ESTGVSTPAPGSASGSNSGNTTPAHKSS 2822
            ..:|.|:.:....||..      |.||:..|      ..:||...|  ....::.....|.|||.
Mouse  1170 VHNGCVKALKDSSSGTE------RAGGRLGKVKGPTFRISGVQVNA--KLVIAHEDELIPLHKSI 1226

  Fly  2823 ALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLY 2887
            ..|..::....|.....||     |....|.|::                               
Mouse  1227 PSDPEERKQYTIPCHTKAA-----HFDIDWGKED------------------------------- 1255

  Fly  2888 YIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRA 2952
                                                        |.:||:|.|::|...:..::.
Mouse  1256 --------------------------------------------DSNLLIGIYEYGYGSWEMIKM 1276

  Fly  2953 DPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDS 3017
            ||:|. :||            ..||          ||.|:........|:.....||...|    
Mouse  1277 DPDLS-LTH------------KILP----------DDPDKKPQAKQLQTRADYLIKLLSRD---- 1314

  Fly  3018 LLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSATP 3082
            |...|.....|...|:.......|:::........|....|..||.:.||.|     .|.|:.:.
Mouse  1315 LAKREAQRLCGAGGSKRRKTRAKKSKAMKSIKVKEEIKSDSSPLPSEKSDED-----DDKLNDSK 1374

  Fly  3083 ELANTSDPKMNKNDAQVSASVSCDP---ADSSSP----------------EAAGKAQGTGVQTGD 3128
            ..:.....|...:||.|..:.|.:|   |:.|..                :||.|          
Mouse  1375 PESKDRSKKSVVSDAPVHITASGEPVPIAEESEELDQKTFSICKERMRPVKAALK---------- 1429

  Fly  3129 AGELDIESEKKDNEKETKEST-------GD----------------------------APAVEAK 3158
              :|| ..||..:|:|..|.|       ||                            ....:|:
Mouse  1430 --QLD-RPEKGLSEREQLEHTRQCLIKIGDHITECLKEYSNPEQIKQWRKNLWIFVSKFTEFDAR 1491

  Fly  3159 KDSAAIARAEGDKTESCTN-NATTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNSH 3221
            |.......|...:.||..| :..:|::          ||....||..:....|...|.::.:|:
Mouse  1492 KLHKLYKHAIKKRQESQQNSDQNSNVA----------TTHVIRNPDMERLKENTNHDDSSRDSY 1545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 52/232 (22%)
HepA 1676..2527 CDD:223627 330/905 (36%)
SDA1 <1693..>1854 CDD:283052 35/162 (22%)
CHROMO <1879..1919 CDD:237991 11/39 (28%)
Chromo 1941..1996 CDD:278797 16/65 (25%)
DEXDc 2048..2197 CDD:238005 64/150 (43%)
Helicase_C 2350..2464 CDD:278689 75/113 (66%)
RR_TM4-6 3728..>3877 CDD:283990
BRK 4569..4613 CDD:197800
Chd1NP_031716.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..250 62/286 (22%)
CHROMO 304..353 CDD:237991 15/51 (29%)
Chromo 388..441 CDD:278797 16/55 (29%)
SNF2_N 482..763 CDD:278600 132/288 (46%)
DEXDc 498..643 CDD:238005 64/150 (43%)
DEAH box 612..615 2/2 (100%)
HDA2-3 716..969 CDD:288366 123/261 (47%)
Helicase_C 801..900 CDD:278689 67/98 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1119 12/41 (29%)
PRK12279 <1276..1466 CDD:138835 49/234 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1322..1407 19/89 (21%)
DUF4208 1407..1498 CDD:290618 15/103 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1503..1588 11/53 (21%)
DUF1777 1581..>1697 CDD:285811
PHA03420 1591..>1691 CDD:177648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1657
3 X 5 AA repeats of H-S-D-H-R 1629..1645
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1670..1711
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0384
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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