DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kis and C17orf64

DIOPT Version :9

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	XP_005257090.1	Gene:	C17orf64 / 124773	HGNCID:	26990	Length:	279	Species:	Homo sapiens

Alignment Length:	279	Identity:	62/279 - (22%)
Similarity:	98/279 - (35%)	Gaps:	88/279 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  5173 GGSAGGGGSSASGSTSHSSSKRQREQDAFKQQMDY--YTKTLGLGSGISLIPTSSAGGSSASSSA 5235
            ||....|.:.|.|..: :.|:||.:..|.....::  ..:|....:.:|.:.|||      |:|.
Human     8 GGRWVAGEARADGGPT-ALSRRQAKNRATLSGDNWARAQRTRRKVTNVSCLETSS------SASP 65

  Fly  5236 ANAAAAAYAAALDAE--QQHQQQQKALSKRARGDLH-----PTKEELAALAAGLPLNLG------ 5287
            |..:...:|..||.:  :..::..:.|.|..| .||     |.|::|..:...|.: ||
Human    66 ARDSLMRHAKGLDQDTFKTCKEYLRPLKKFLR-KLHLPRDLPQKKKLKYMKQSLVV-LGDHINTF 128

  Fly  5288 ---------------------ASMSSIE-KSLRGGSSSSSSSTPA----------PMTAEQDKVT 5320
                                 :..|.:| |.||.....:.||.||          |.|||.|.:.
Human   129 LQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVRRKTFRPSTAEGDILR 193

  Fly  5321 LTPLNASGGGSGSSSSSAAAAGLAANLPSQTTITIAPPISSGASTSSERSERSESRISLTITNA- 5384
            |                ..|..:.|..|.:.:....|  ..||:...:|.|      ...:.:|
Human   194 L----------------GCAGEVLAGRPGRQSAQALP--CMGAAQQHQRHE------GAAVQHAD 234

  Fly  5385 -------ADAAKLPPPYEE 5396
                   |.|||:|.|.:|
Human   235 PRSREPPAWAAKIPGPCQE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191
		HepA	1676..2527	CDD:223627
		SDA1	<1693..>1854	CDD:283052
		CHROMO	<1879..1919	CDD:237991
		Chromo	1941..1996	CDD:278797
		DEXDc	2048..2197	CDD:238005
		Helicase_C	2350..2464	CDD:278689
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
C17orf64	XP_005257090.1	DUF4208	85..165	CDD:290618	16/81 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900