Protein Alignment kis and Chd4

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_006237458.1
• Gene: Chd4 / 117535
• RGDID: 620064
• Length: 1956
• Species: Rattus norvegicus
• Alignment Length: 2381
• Identity: 612/2381 - (25%)
• Similarity: 911/2381 - (38%)
• Gaps: 761/2381 - (31%)

  Fly  1262 VTQGAGDTSVVGMLEYSEGMGDLSQD----VHSANELDTSTDGS-------GKKKKPRKPRTPKD 1315
            :..|.|..|........|.|..|..:    .|..||.|...|.|       .|||||:|||.||
  Rat     1 MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEDDPEEDLSEAETPKLKKKKKPKKPRDPK- 64

  Fly  1316 PNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRR----KQYGEDGAEQTGEGSE-VEDN 1375
                    .||:|:.|                     |.|    :|.|    :.:|||.| ||:
  Rat    65 --------IPKSKRQK---------------------KERLLLCRQLG----DSSGEGPEFVEE- 95

  Fly  1376 KPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGD 1440
                      |.||...|     |.|..||
  Rat    96 ----------DEEAALRS-----DSEGSDY----------------------------------- 110

  Fly  1441 PASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTP 1505
               ||.::.:|:                       |..|..||.:::.:...|.:.:||
  Rat   111 ---TPGKKKKKK-----------------------LGPKKEKKSKSKRKEEEEEEDDDD------ 143

  Fly  1506 PPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFS-DDENSLLVASPVKKDKKPSANASNSNAGS 1569
                      ||.:.:||........::|:...|| :|..:|.......:..:|...|.|....
  Rat   144 ----------DSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIA- 197

  Fly  1570 DVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLE-ASSSTSAVAEKERQISTDAANAAMSSKPN 1633
             |.|.....||:.      .|..:|.|...||... |:::.:|||..|..::  |...|....|.
  Rat   198 -VSKMMMVLGAKW------REFSTNNPFKGSSGASVAAAAAAAVAVVESMVT--ATEVAPPPPPV 253

  Fly  1634 YVYINTGDEDSMVVQLVLAMRMGKRELILDKPK-------EKAPEPK------------------ 1673
            .|.|...           ..:.||......|||       .|.|:||
  Rat   254 EVPIRKA-----------KTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKR 307

  Fly  1674 ---QDEE---KSELDEATTDK-PEGDEKFKTEGESKKDL-TDSEETKLESSAMEVDSKEESEPDD 1730
               :|::   :|:.|:|:.:. ...|........|:|.| |..::.|.|.....||..|....|.
  Rat   308 SSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTAKKKKKGEEEVTAVDGYETDHQDY 372

  Fly  1731 SKKSDEDNK-----------DKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVL 1784
            .:...:..:           ....::.|.|.....|.|.|..:.|.::.|     .:||.|
  Rat   373 CEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWE-----AKEDNS---- 428

  Fly  1785 TADHAKEPETVLEKMEVDEKANDDQ----SAVSKAEGSDEKSTDDSNPEEATTE---------KN 1836
                  |.|.:||::..|.:..||.    ..|.|..|  |....|:.|......         .|
  Rat   429 ------EGEEILEEVGGDPEEEDDHHMEFCRVCKDGG--ELLCCDTCPSSYHIHCLNPPLPEIPN 485

  Fly  1837 KESL-------EIEGEKERV---KEGEESVKKENDEKTEAD--------MENKPEPVFIDVEEYF 1883
            .|.|       .::|:.:::   |.|:...........:||        :|.:||      .::|
  Rat   486 GEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPE------RQFF 544

  Fly  1884 VKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDF--------- 1939
            ||::..||.||.|.:|.:|   :.......|.:|:|         |..|||.:.||
  Rat   545 VKWQGMSYWHCSWVSELQL---ELHCQVMFRNYQRK---------NDMDEPPSGDFGGDEEKSRK 597

  Fly  1940 ------------------------TEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELE 1980
                                    ..:.|:|:   |:.:..|..  |||:||:.|||:..:|| .
  Rat   598 RKNKDPKFAEMEERFYRYGIKPEWMMIHRILN---HSVDKKGHV--HYLIKWRDLPYDQASWE-S 656

  Fly  1981 EDVDNDKIEQYLRFNKIPQRSEWKSKK-------RPHPELWK-------------------KLEK 2019
            |||:   |:.|..|    ::|.|..::       ||..:|.|                   |.|:
  Rat   657 EDVE---IQDYDLF----KQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYER 714

  Fly  2020 TPVY--KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFL 2081
            .|.|  ..|.:|.|||:||||||:|||....:.|||||||||||:|:..|::|:|:.| .:||||
  Rat   715 QPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFL 779

  Fly  2082 VIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYK-------TESGKVLKE-PIK 2137
            |.||||||.||:||||.|. ||.||.|.|...|:.:|::.|:.::       .::.::.|| .:|
  Rat   780 VSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVK 844

  Fly  2138 FNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNI 2202
            |:||:|::|:|..|...|.:.:|...::||||||||...|....|...:|:|::||:|||||||:
  Rat   845 FHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNL 909

  Fly  2203 SELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETII 2267
            .|||.|||||.|.:|.:.|.|:.||..:..|:::.||..:|.|.||||||.||.|::..|.|.|:
  Rat   910 EELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIV 974

  Fly  2268 EVELTNIQKKYYRGILEQNFSFLK-KGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFK 2331
            .|||:.:|||||:.||.:||..|. :|  ..|..:|:|.:|:|:|||.||||...|..:..
  Rat   975 RVELSPMQKKYYKYILTRNFEALNARG--GGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAP---- 1033

  Fly  2332 SQHGEDPESYYKN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFE 2394
                :.|...|..  ||.::||::|:.|:|..||..||||||||||.:.||:|||:|.:..|.:|
  Rat  1034 ----KMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYE 1094

  Fly  2395 RIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQAR 2459
            ||||.|.||:|||||||::.||:.:|.|||.|:||||||||..|||||||||||||.||:||.:|
  Rat  1095 RIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSR 1159

  Fly  2460 CHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLL 2524
            .|||||.|.|.|||.:.|.:.|..:...|..|:.|...|::.  ..|||.|:   :||:|::|:|
  Rat  1160 AHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRP--GLGSKTGS---MSKQELDDIL 1219

  Fly  2525 KKGAYGAVMDD--DNAGDKFCEEDI------DSILKR---RTQVITMESE-KG-----STFSKAS 2572
            |.|......|:  |..||....||.      |..::|   |.|..|.::| :|     |:|..|.
  Rat  1220 KFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQ 1284

  Fly  2573 FAA----SGNRSDITID--------DPDFWTKW----------------------AKKVDIDPDA 2603
            :..    .|...::..:        |||:|.|.                      .|:|:.: |.
  Rat  1285 YVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYN-DG 1348

  Fly  2604 CERDETEDLVLSEPR-----RRTQIKRYGH---------EDVMELNSEES-SNENSDEEGGIGLR 2653
            .:.|..   |...||     |.|:.....|         :|..:..|:.| ::|..||:......
  Rat  1349 SQEDRG---VCGRPRPPPTGRSTRAVGPAHLPSLPPDWQDDQSDNQSDYSVASEEGDEDFDERSE 1410

  Fly  2654 SRRRKEKRDRAREKKGNDEYIPRERDALAALG--LEEIQYGNWAKSECFKVEKGLLSFGWGRWSE 2716
            :.||..::....:|   |:.:|   ..||.:|  :|.:.: |..:.:.|.  ..::.:|
  Rat  1411 APRRPSRKGLRNDK---DKPLP---PLLARVGGNIEVLGF-NARQRKAFL--NAIMRYG------ 1460

  Fly  2717 LLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKT----FIWDLITPTEDGEV-------- 2769
            :.....|...|...|:..             |.:::.|.    |:..|..|..||..
  Rat  1461 MPPQDAFTTQWLVRDLRG-------------KSEKEFKAYVSLFMRHLCEPGADGAETFADGVPR 1512

  Fly  2770 QKISRDH----SGLHNLVPR------GRNGG---------KSNKESTGVSTPAPGSASGSNSGNT 2815
            :.:||.|    .|:.:|:.:      ..||.         :.||:.:...:|:|.:.:.|..|:|
  Rat  1513 EGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDT 1577

  Fly  2816 ---TPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHAN 2877
               |||....|.||...:.                  |...::|..:.:
  Rat  1578 QPNTPAPVPPAEDGIKIEE------------------NSLKEEESTEGE---------------- 1608

  Fly  2878 KVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKH 2942
                                 :::|...|...:....||.|...|:|...|.
  Rat  1609 ---------------------KEVKPTAPEVTVECAQPPAPAPAPASGPGPT------------- 1639

  Fly  2943 GCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDD-ANSKHDDGDEVDDDGTTTTKDSDS 3006
                                 .|.|         |..||| |.::..:|:|
  Rat  1640 ---------------------PGPA---------PAPEDDKAPAEPPEGEE-------------- 1660

  Fly  3007 TKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTV--------SESSYKSEVLPG 3063
             |:...:.|:...:|....|.|.:..|.|     :.:|..|.|.:        .|...|.|||..
  Rat  1661 -KVEKAEVKERAEEPMETESKGTTEVEKA-----EEKSAVDLTPIVVEDKEEKKEEEEKKEVLLQ 1719

  Fly  3064 KGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGD 3128
            .|.              ||:  :.||.|..||                      ..|.......|
  Rat  1720 NGE--------------TPK--DLSDEKQKKN----------------------LKQRFMFNIAD 1746

  Fly  3129 AGELDIESEKKDNE------KETKE---------------STGDAPAVEAKKDSAAIARAEGDKT 3172
            .|..::.|..::.|      |:|.|               :.|.|...:.:.|.......|..|.
  Rat  1747 GGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKG 1811

  Fly  3173 ESCTNN-----------------ATTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNS 3220
            |....|                 ....|..........|.:...::| |.|.|:........:.|
  Rat  1812 EMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHP-SMALNTRFAEVECLAES 1875

  Fly  3221 HLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKEELKLQQKA---KL 3282
            |..| .:||:||:.|                  .|..|.:|:.      :.|||....||   :|
  Rat  1876 HQHL-SKESMAGNKP------------------ANAVLHKVLK------QLEELLSDMKADVTRL 1915

  Fly  3283 QALVSSTPPLSV-----------------PTTPTLQSMQMQ 3306
            .|.::..||::|                 |..|..|..|.|
  Rat  1916 PATIARIPPVAVRLQMSERNILSRLANRAPEPPPQQVAQQQ 1956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	0/2 (0%)
		PRK12678	1319..>1500	CDD:237171	31/185 (17%)
		PTZ00121	<1419..1923	CDD:173412	112/580 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	17/74 (23%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	21/90 (23%)
		PLN03142	2029..>2606	CDD:215601	275/640 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd4	XP_006237458.1	CHDNT	164..217	CDD:462357	13/60 (22%)
		PHD1_CHD_II	372..414	CDD:277006	5/41 (12%)
		PHD2_CHD_II	451..493	CDD:277007	9/43 (21%)
		CD1_tandem_CHD3-4_like	498..576	CDD:349314	19/86 (22%)
		CD2_tandem_CHD3-4_like	619..673	CDD:349309	21/66 (32%)
		PLN03142	724..>1281	CDD:215601	264/571 (46%)
		DEXHc_CHD4	726..957	CDD:350814	110/230 (48%)
		DUF1087	1302..1345	CDD:461922	7/42 (17%)
		CHDII_SANT-like	1409..1549	CDD:461920	29/167 (17%)
		CHDCT2	1770..1915	CDD:462358	30/170 (18%)