DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and CHD4

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001264.2 Gene:CHD4 / 1108 HGNCID:1919 Length:1912 Species:Homo sapiens


Alignment Length:2307 Identity:592/2307 - (25%)
Similarity:908/2307 - (39%) Gaps:698/2307 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1262 VTQGAGDTSVVGMLEYSEGMGDLSQD----VHSANELD-------TSTDGSGKKKKPRKPRTPKD 1315
            :..|.|..|........|.|..|..:    .|..||.|       |.|....|||||:|||.|| 
Human     1 MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPK- 64

  Fly  1316 PNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSE-VEDNKPLV 1379
                    .||:|:.|                     |.|........:.:|||.| ||:.:.:.
Human    65 --------IPKSKRQK---------------------KERMLLCRQLGDSSGEGPEFVEEEEEVA 100

  Fly  1380 PKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPAST 1444
            .::                |.|..||                                      |
Human   101 LRS----------------DSEGSDY--------------------------------------T 111

  Fly  1445 PSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSP 1509
            |.::.:|:                       |..|..||.:::.:...|.:.:||          
Human   112 PGKKKKKK-----------------------LGPKKEKKSKSKRKEEEEEEDDDD---------- 143

  Fly  1510 PPDSEMDSNKRRSSRNTQRKKYIDDVMLRFS-DDENSLLVASPVKKDKKPSANASNSNAGSDVEK 1573
                  ||.:.:||........::|:...|| :|..:|.......:..:|...|.|....  |.|
Human   144 ------DSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIA--VSK 200

  Fly  1574 TEPQSGAEGDAAQEVGEEKSNLPLDESSQLE-ASSSTSAVAEKERQISTDAANAAMSSKPNYVYI 1637
            .....||:.      .|..:|.|...||... |:::.:|||..|..::  |...|....|..|.|
Human   201 MMMVLGAKW------REFSTNNPFKGSSGASVAAAAAAAVAVVESMVT--ATEVAPPPPPVEVPI 257

  Fly  1638 NTGDEDSMVVQLVLAMRMGKRELILDKPK-------EKAPEPK---------------------Q 1674
            ...           ..:.||......|||       .|.|:||                     :
Human   258 RKA-----------KTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSE 311

  Fly  1675 DEE---KSELDEATTDK-PEGDEKFKTEGESKKDL-TDSEETKLESSAMEVDSKEESEPDDSKKS 1734
            |::   :|:.|:|:.:. ...|........|:|.| |..::.|.|.....||..|....|..:..
Human   312 DDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVC 376

  Fly  1735 DEDNK-----------DKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADH 1788
            .:..:           ....::.|.|.....|.|.|..:.|.::.|     .:||.|        
Human   377 QQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWE-----AKEDNS-------- 428

  Fly  1789 AKEPETVLEKMEVDEKANDDQ----SAVSKAEGSDEKSTDDSNPEEATTE---------KNKESL 1840
              |.|.:||::..|.:..||.    ..|.|..|  |....|:.|......         .|.|.|
Human   429 --EGEEILEEVGGDLEEEDDHHMEFCRVCKDGG--ELLCCDTCPSSYHIHCLNPPLPEIPNGEWL 489

  Fly  1841 -------EIEGEKERV---KEGEESVKKENDEKTEAD--------MENKPEPVFIDVEEYFVKYR 1887
                   .::|:.:::   |.|:...........:||        :|.:||      .::|||::
Human   490 CPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPE------RQFFVKWQ 548

  Fly  1888 NFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDF------------- 1939
            ..||.||.|.:|.:|   :.......|.:|:|         |..|||.:.||             
Human   549 GMSYWHCSWVSELQL---ELHCQVMFRNYQRK---------NDMDEPPSGDFGGDEEKSRKRKNK 601

  Fly  1940 --------------------TEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVD 1984
                                ..:.|:|:   |:.:..|..  |||:||:.|||:..:|| .|||:
Human   602 DPKFAEMEERFYRYGIKPEWMMIHRILN---HSVDKKGHV--HYLIKWRDLPYDQASWE-SEDVE 660

  Fly  1985 NDKIEQYLRFNKIPQRSEWKSKK-------RPHPELWK-------------------KLEKTPVY 2023
               |:.|..|    ::|.|..::       ||..:|.|                   |.|:.|.|
Human   661 ---IQDYDLF----KQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEY 718

  Fly  2024 --KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFLVIAP 2085
              ..|.:|.|||:||||||:|||....:.|||||||||||:|:..|::|:|:.| .:|||||.||
Human   719 LDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAP 783

  Fly  2086 LSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYK-------TESGKVLKE-PIKFNVL 2141
            ||||.||:||||.|. ||.||.|.|...|:.:|::.|:.::       .::.::.|| .:||:||
Human   784 LSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVL 848

  Fly  2142 ITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELF 2206
            :|::|:|..|...|.:.:|...::||||||||...|....|...:|:|::||:|||||||:.|||
Human   849 LTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELF 913

  Fly  2207 SLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVEL 2271
            .|||||.|.:|.:.|.|:.||..:..|:::.||..:|.|.||||||.||.|::..|.|.|:.|||
Human   914 HLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVEL 978

  Fly  2272 TNIQKKYYRGILEQNFSFLK-KGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHG 2335
            :.:|||||:.||.:||..|. :|  ..|..:|:|.:|:|:|||.||||...|..:..        
Human   979 SPMQKKYYKYILTRNFEALNARG--GGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAP-------- 1033

  Fly  2336 EDPESYYKN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDG 2398
            :.|...|..  ||.::||::|:.|:|..||..||||||||||.:.||:|||:|.:..|.:|||||
Human  1034 KMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDG 1098

  Fly  2399 RIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRI 2463
            .|.||:|||||||::.||:.:|.|||.|:||||||||..|||||||||||||.||:||.:|.|||
Human  1099 GITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRI 1163

  Fly  2464 GQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGA 2528
            ||.|.|.|||.:.|.:.|..:...|..|:.|...|::.  ..|||.|:   :||:|::|:||.|.
Human  1164 GQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRP--GLGSKTGS---MSKQELDDILKFGT 1223

  Fly  2529 YGAVMDD--DNAGDKFCEEDI------DSILKR---RTQVITMESE-KG-----STFSKASFAA- 2575
            .....|:  |..||....||.      |..::|   |.|..|.::| :|     |:|..|.:.. 
Human  1224 EELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVR 1288

  Fly  2576 ---SGNRSDITID--------DPDFWTKWAKKVDIDPDACERDETEDLV--LSEPRR-RTQIK-R 2625
               .|...::..:        |||:|.|..:.       ....:.|||.  |.:.:| |.|:. .
Human  1289 EEEMGEEEEVEREIIKQEESVDPDYWEKLLRH-------HYEQQQEDLARNLGKGKRIRKQVNYN 1346

  Fly  2626 YGHEDVMELNSEESSNEN----SDEEGGIGLRSRRRKEKR-DRAREKKGNDEYIPRERDALAALG 2685
            .|.::..:...::|.|::    :.|||......|....:| .|...:...|:.:|   ..||.:|
Human  1347 DGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLP---PLLARVG 1408

  Fly  2686 --LEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYK 2748
              :|.:.: |..:.:.|.  ..::.:|      :.....|...|...|:..             |
Human  1409 GNIEVLGF-NARQRKAFL--NAIMRYG------MPPQDAFTTQWLVRDLRG-------------K 1451

  Fly  2749 GDEKIKT----FIWDLITPTEDGEV--------QKISRDH----SGLHNLVPR------GRNGG- 2790
            .:::.|.    |:..|..|..||..        :.:||.|    .|:.:|:.:      ..||. 
Human  1452 SEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRW 1516

  Fly  2791 --------KSNKESTGVSTPAPGSASGSNSGNT---TPAHKSSALDG------------SDKDSG 2832
                    :.||:.:...:|:|.:.:.|..|:|   |||....|.||            |.:...
Human  1517 SMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEK 1581

  Fly  2833 GINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDF 2897
            .:.::|...|:.....|...|:.||                                        
Human  1582 EVKSTAPETAIECTQAPAPASEDEK---------------------------------------- 1606

  Fly  2898 VQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHV 2962
                        :.:.||...::|..:              ..|...|  ..|..:|.       
Human  1607 ------------VVVEPPEGEEKVEKA--------------EVKERTE--EPMETEPK------- 1636

  Fly  2963 GAGAAG-----DDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPE 3022
              |||.     :..|:...||..:|...|.::            ::.....|..|:....|.|.:
Human  1637 --GAADVEKVEEKSAIDLTPIVVEDKEEKKEE------------EEKKEVMLQNGETPKDLNDEK 1687

  Fly  3023 RPSSSGKSSSEN-ASGG----NDKTESENDATTVSESSYK-------SEVLPGKGSDLDVSVAQQ 3075
            :..:..:....| |.||    :...::|..|.||::.:|:       ..:|.|   .::...|:.
Human  1688 QKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAG---IINHGYARW 1749

  Fly  3076 DALSATPELANTSDP---KMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESE 3137
            ..:...|..|..::|   :||:.:.                                  |:|:::
Human  1750 QDIQNDPRYAILNEPFKGEMNRGNF----------------------------------LEIKNK 1780

  Fly  3138 KKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTTITNTTTTTNNP 3202
            ......:..|   .|..:|                |.....|..|:|               .:|
Human  1781 FLARRFKLLE---QALVIE----------------EQLRRAAYLNMS---------------EDP 1811

  Fly  3203 S--SKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAY 3265
            |  |.|.|:........:.||..| .:||:||:.|                  .|..|.:|:.  
Human  1812 SHPSMALNTRFAEVECLAESHQHL-SKESMAGNKP------------------ANAVLHKVLK-- 1855

  Fly  3266 QRNYKKEELKLQQKA---KLQALVSSTPPLSV 3294
                :.|||....||   :|.|.::..||::|
Human  1856 ----QLEELLSDMKADVTRLPATIARIPPVAV 1883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 56/276 (20%)
HepA 1676..2527 CDD:223627 347/971 (36%)
SDA1 <1693..>1854 CDD:283052 39/195 (20%)
CHROMO <1879..1919 CDD:237991 12/39 (31%)
Chromo 1941..1996 CDD:278797 20/54 (37%)
DEXDc 2048..2197 CDD:238005 70/158 (44%)
Helicase_C 2350..2464 CDD:278689 74/113 (65%)
RR_TM4-6 3728..>3877 CDD:283990
BRK 4569..4613 CDD:197800
CHD4NP_001264.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157 52/278 (19%)
CHDNT 164..216 CDD:285335 12/59 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..360 25/127 (20%)
PHD1_CHD_II 372..414 CDD:277006 5/41 (12%)
PHD2_CHD_II 451..493 CDD:277007 9/43 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..538 4/27 (15%)
CHROMO <540..577 CDD:237991 13/45 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..603 6/24 (25%)
CHROMO 622..676 CDD:214605 22/66 (33%)
SNF2_N 729..1025 CDD:278600 143/297 (48%)
DEXDc 746..904 CDD:238005 70/157 (45%)
DEAH box 873..876 2/2 (100%)
Helicase_C 1068..1164 CDD:278689 65/95 (68%)
DUF1087 1302..1352 CDD:283996 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1401 10/56 (18%)
DUF1086 1385..1521 CDD:283992 28/160 (18%)
Neuromodulin <1517..1649 CDD:284117 30/208 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1525..1562 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1570..1589 2/18 (11%)
Required for interaction with PCNT. /evidence=ECO:0000269|PubMed:17626165 1577..1912 77/492 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1644 14/126 (11%)
CHDCT2 1726..1896 CDD:285336 44/254 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D54215at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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