DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and CHD2

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001262.3 Gene:CHD2 / 1106 HGNCID:1917 Length:1828 Species:Homo sapiens


Alignment Length:1850 Identity:506/1850 - (27%)
Similarity:787/1850 - (42%) Gaps:480/1850 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1554 KDKKPSANAS-NSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKER 1617
            |||....::| :|||.|. ..:|..||:: ..:|...|:.|:......|:..:||.:|     |.
Human     5 KDKSQEEDSSLHSNASSH-SASEEASGSD-SGSQSESEQGSDPGSGHGSESNSSSESS-----ES 62

  Fly  1618 QISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPK--EKAP---------- 1670
            |..:::.:|...|:|             |:.........|:|.|.|..|  |:.|          
Human    63 QSESESESAGSKSQP-------------VLPEAKEKPASKKERIADVKKMWEEYPDVYGVRRSNR 114

  Fly  1671 ---EPKQ---DEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPD 1729
               ||.:   .||.|...|:.:.|..|..:.|.:.:.|::.::.|:        |..:..|||| 
Human   115 SRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQ--------EQGTSAESEP- 170

  Fly  1730 DSKKSDEDNKDKDKMEVDDE-VGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPE 1793
                  |..|.|.:..|... |.|...:.:|:.|....|.:::|...::|        |.|.:.:
Human   171 ------EQKKVKARRPVPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDD--------DEAPKRQ 221

  Fly  1794 T-------VLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKE 1851
            |       |..|.:.|.:.:.|.......||.||:            :.|.|::|...:....|:
Human   222 TRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQ------------QDNSETIEKVLDSRLGKK 274

  Fly  1852 GEE-------SVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRV 1909
            |..       :::...|...:.|.|.....:     :|.:|::.:||:|..|.:||.|.:...:.
Human   275 GATGASTTVYAIEANGDPSGDFDTEKDEGEI-----QYLIKWKGWSYIHSTWESEESLQQQKVKG 334

  Fly  1910 AAKIRRFQQKQS--------------QQLNIFENIEDEPFNQDFTEVDRVL------------DM 1948
            ..|:..|::|:.              :..|..:.:..| .|:.:..|:||:            |.
Human   335 LKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASE-LNKQYQIVERVIAVKTSKSTLGQTDF 398

  Fly  1949 SVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQ-----YLRFNK--IPQRSEWKSK 2006
            ..|:.:.:......||.||..|||.:|:|| :|.:...|.:.     :.|.|.  ||.|.....|
Human   399 PAHSRKPAPSNEPEYLCKWMGLPYSECSWE-DEALIGKKFQNCIDSFHSRNNSKTIPTRECKALK 462

  Fly  2007 KRPHPELWKKLEKTPVYKGGNS--LRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFV- 2068
            :||.   :..|:|.|.|.||.:  ||.|||||||||..||...::.|||||||||||||:::|: 
Human   463 QRPR---FVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLS 524

  Fly  2069 HSVYEYGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVL 2132
            :..:::.:.||||::.||||:.:||||||.|. ::|||||.|.:.|:..|::||:.:..      
Human   525 YLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQ------ 583

  Fly  2133 KEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTP 2197
            .:.:|||.||||:|:::.|...|.:.||....:||||||||.:..|.:.|......||:|::|||
Human   584 TKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTP 648

  Fly  2198 LQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPK 2262
            |||::.||:|||:|:.|.:|...|:|..:.|..| |.....|..:|:|.:|||:|.||||||..|
Human   649 LQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGR-ENGYQSLHKVLEPFLLRRVKKDVEKSLPAK 712

  Fly  2263 EETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQ 2327
            .|.|:.||::.:||:||:.||.:|:..|.|||..:. ...:|.:|||:|||.|.||:...||   
Human   713 VEQILRVEMSALQKQYYKWILTRNYKALAKGTRGST-SGFLNIVMELKKCCNHCYLIKPPEE--- 773

  Fly  2328 YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYP 2392
                 ...|:.:....:||.|:||::|:||||.:|:..|:||||||||||.||||.:||..:.||
Human   774 -----NERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYP 833

  Fly  2393 FERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQ 2457
            |:|:||.|:|.:|::|:|.::..||:.|.|||.|:||||||||.:||||:|:|||||||||||||
Human   834 FQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQ 898

  Fly  2458 ARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQG-------SKDGNNKQL 2515
            ||.|||||:|.|.||||:.:.|.|.|:.::|..|:.||..|:|.|:|.|       |...|:...
Human   899 ARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPF 963

  Fly  2516 SKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILK----RRTQVITMES-EKGSTFSKASFAA 2575
            :|:|:..:||.||.....:.:....:..|.|||.||:    |..:|.|..: |..|.|..|:||.
Human   964 NKEELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKVANFAT 1028

  Fly  2576 SGNRSDITIDDPDFW-----TKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED----- 2630
            ..:..::.......|     .:..|||:.:    ||.:..:.:...||.|:..|:....|     
Human  1029 MEDEEELEERPHKDWDEIIPEEQRKKVEEE----ERQKELEEIYMLPRIRSSTKKAQTNDSDSDT 1089

  Fly  2631 -----VMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKG-NDEYIPRERDALAALGLEEI 2689
                 ....::.||..|:||::.....|.|.|..::|..   :| .|..|.|...|....||.  
Human  1090 ESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLV---EGFTDAEIRRFIKAYKKFGLP-- 1149

  Fly  2690 QYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIK 2754
                ..:.||.           .|.:||:          |..|.|..|:                
Human  1150 ----LERLECI-----------ARDAELV----------DKSVADLKRL---------------- 1173

  Fly  2755 TFIWDLITPTEDGEVQKISRDHSGLHN-LVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPA 2818
                        ||:         :|| .|...:...:..||:.     :.|...|...|.|   
Human  1174 ------------GEL---------IHNSCVSAMQEYEEQLKENA-----SEGKGPGKRRGPT--- 1209

  Fly  2819 HKSSALDGSDKDSGGINASAVAAAVTSI--HD----------PNHWSKKEKYDADAYLEGAYKKH 2871
                           |..|.|...|.||  |:          |....:|:||             
Human  1210 ---------------IKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKY------------- 1246

  Fly  2872 LGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLL 2936
                  .:..||:..::       |....::|                            |..||
Human  1247 ------CLTCRVKAAHF-------DVEWGVED----------------------------DSRLL 1270

  Fly  2937 VGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTT 3001
            :|.|:||...:..::.||.|.....:             ||:..|    |...|.::.      |
Human  1271 LGIYEHGYGNWELIKTDPELKLTDKI-------------LPVETD----KKPQGKQLQ------T 1312

  Fly  3002 KDSDSTKL-----------TGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESS 3055
            :.....||           |||:  ::.|...:|                :.:.||....:.|. 
Human  1313 RADYLLKLLRKGLEKKGAVTGGE--EAKLKKRKP----------------RVKKENKVPRLKEE- 1358

  Fly  3056 YKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQ 3120
                    .|.:|.                                    .|..|.:|...|:.:
Human  1359 --------HGIELS------------------------------------SPRHSDNPSEEGEVK 1379

  Fly  3121 GTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNIST 3185
            ..|::..       ..:||..:||.||:  ....:.::||.      ||||...           
Human  1380 DDGLEKS-------PMKKKQKKKENKEN--KEKQMSSRKDK------EGDKERK----------- 1418

  Fly  3186 TTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPS 3250
                    .:......|.|..|.|::.:..:....|:       .|||.|..:...||......:
Human  1419 --------KSKDKKEKPKSGDAKSSSKSKRSQGPVHI-------TAGSEPVPIGEDEDDDLDQET 1468

  Fly  3251 MQDLNTRLRRVITAYQRNYKKEE-LKLQQK 3279
            ......|:|.|..|.::..|.:: |.:|::
Human  1469 FSICKERMRPVKKALKQLDKPDKGLNVQEQ 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 58/251 (23%)
HepA 1676..2527 CDD:223627 331/909 (36%)
SDA1 <1693..>1854 CDD:283052 35/168 (21%)
CHROMO <1879..1919 CDD:237991 11/39 (28%)
Chromo 1941..1996 CDD:278797 18/71 (25%)
DEXDc 2048..2197 CDD:238005 65/150 (43%)
Helicase_C 2350..2464 CDD:278689 73/113 (65%)
RR_TM4-6 3728..>3877 CDD:283990
BRK 4569..4613 CDD:197800
CHD2NP_001262.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..243 64/280 (23%)
CHROMO 282..344 CDD:237991 14/66 (21%)
Chromo 379..447 CDD:278797 17/68 (25%)
SNF2_N 487..768 CDD:278600 132/288 (46%)
DEXDc 503..648 CDD:238005 65/150 (43%)
DEAH box 617..620 2/2 (100%)
Helicase_C 790..905 CDD:278689 73/114 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1124 19/97 (20%)
DUF5102 <1042..1165 CDD:293709 32/156 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1331..1462 37/234 (16%)
DUF4208 1471..1553 CDD:290618 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1638
DUF1777 1661..>1749 CDD:285811
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1680..1828
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0384
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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