Protein Alignment kis and Chd4

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001390521.1
• Gene: Chd4 / 107932
• MGIID: 1344380
• Length: 1922
• Species: Mus musculus
• Alignment Length: 2353
• Identity: 600/2353 - (25%)
• Similarity: 917/2353 - (38%)
• Gaps: 739/2353 - (31%)

  Fly  1262 VTQGAGDTSVVGMLEYSEGMGDLSQD----VHSANELDTSTDGS-------GKKKKPRKPRTPKD 1315
            :..|.|..|........|.|..|..:    .|..||.|...|.|       .|||||:|||.||
Mouse     1 MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPDEDLSEAETPKLKKKKKPKKPRDPK- 64

  Fly  1316 PNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRR----KQYGEDGAEQTGEGSE-VEDN 1375
                    .||:|:.|                     |.|    :|.|    :.:|||.| ||:.
Mouse    65 --------IPKSKRQK---------------------KERLLLCRQLG----DSSGEGPEFVEEE 96

  Fly  1376 KPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGD 1440
            :.:..::                |.|..||
Mouse    97 EEVALRS----------------DSEGSDY----------------------------------- 110

  Fly  1441 PASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTP 1505
               ||.::.:|:                       |..|..||.:::.:...|.:.|||
Mouse   111 ---TPGKKKKKK-----------------------LGPKKEKKSKSKRKEEEEEEDEDD------ 143

  Fly  1506 PPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFS-DDENSLLVASPVKKDKKPSANASNSNAGS 1569
                      ||.:.:||........::|:...|| :|..:|.......:..:|...|.|....
Mouse   144 ----------DSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIA- 197

  Fly  1570 DVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLE-ASSSTSAVAEKERQISTDAANAAMSSKPN 1633
             |.|.....||:.      .|..:|.|...||... |:::.:|||..|..::  |...|....|.
Mouse   198 -VSKMMMVLGAKW------REFSTNNPFKGSSGASVAAAAAAAVAVVESMVT--ATEVAPPPPPV 253

  Fly  1634 YVYINTGDEDSMVVQLVLAMRMGKRELILDKPK-------EKAPEPK------------------ 1673
            .|.|...           ..:.||......|||       .|.|:||
Mouse   254 EVPIRKA-----------KTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKR 307

  Fly  1674 ---QDEE---KSELDEATTDK-PEGDEKFKTEGESKKDL-TDSEETKLESSAMEVDSKEESEPDD 1730
               :|::   :|:.|:|:.:. ...|........|:|.| |..::.|.|.....||..|....|.
Mouse   308 SSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTAKKKKKGEEEVTAVDGYETDHQDY 372

  Fly  1731 SKKSDEDNK-----------DKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVL 1784
            .:...:..:           ....::.|.|.....|.|.|..:.|.::.|     .:||.|
Mouse   373 CEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWE-----AKEDNS---- 428

  Fly  1785 TADHAKEPETVLEKMEVDEKANDDQ----SAVSKAEGSDEKSTDDSNPEEATTE---------KN 1836
                  |.|.:||::..|.:..||.    ..|.|..|  |....|:.|......         .|
Mouse   429 ------EGEEILEEVGGDPEEEDDHHMEFCRVCKDGG--ELLCCDTCPSSYHIHCLNPPLPEIPN 485

  Fly  1837 KESL-------EIEGEKERV---KEGEESVKKENDEKTEAD--------MENKPEPVFIDVEEYF 1883
            .|.|       .::|:.:::   |.|:...........:||        :|.:||      .::|
Mouse   486 GEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPE------RQFF 544

  Fly  1884 VKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDF--------- 1939
            ||::..||.||.|.:|.:|   :.......|.:|:|         |..|||.:.||
Mouse   545 VKWQGMSYWHCSWVSELQL---ELHCQVMFRNYQRK---------NDMDEPPSGDFGGDEEKSRK 597

  Fly  1940 ------------------------TEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELE 1980
                                    ..:.|:|:   |:.:..|..  |||:||:.|||:..:|| .
Mouse   598 RKNKDPKFAEMEERFYRYGIKPEWMMIHRILN---HSVDKKGHV--HYLIKWRDLPYDQASWE-S 656

  Fly  1981 EDVDNDKIEQYLRFNKIPQRSEWKSKK-------RPHPELWK-------------------KLEK 2019
            |||:   |:.|..|    ::|.|..::       ||..:|.|                   |.|:
Mouse   657 EDVE---IQDYDLF----KQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYER 714

  Fly  2020 TPVY--KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFL 2081
            .|.|  ..|.:|.|||:||||||:|||....:.|||||||||||:|:..|::|:|:.| .:||||
Mouse   715 QPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFL 779

  Fly  2082 VIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYK-------TESGKVLKE-PIK 2137
            |.||||||.||:||||.|. ||.||.|.|...|:.:|::.|:.::       .::.::.|| .:|
Mouse   780 VSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVK 844

  Fly  2138 FNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNI 2202
            |:||:|::|:|..|...|.:.:|...::||||||||...|....|...:|:|::||:|||||||:
Mouse   845 FHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNL 909

  Fly  2203 SELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETII 2267
            .|||.|||||.|.:|.:.|.|:.||..:..|:::.||..:|.|.||||||.||.|::..|.|.|:
Mouse   910 EELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIV 974

  Fly  2268 EVELTNIQKKYYRGILEQNFSFLK-KGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFK 2331
            .|||:.:|||||:.||.:||..|. :|  ..|..:|:|.:|:|:|||.||||...|..:..
Mouse   975 RVELSPMQKKYYKYILTRNFEALNARG--GGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAP---- 1033

  Fly  2332 SQHGEDPESYYKN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFE 2394
                :.|...|..  ||.::||::|:.|:|..||..||||||||||.:.||:|||:|.:..|.:|
Mouse  1034 ----KMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYE 1094

  Fly  2395 RIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQAR 2459
            ||||.|.||:|||||||::.||:.:|.|||.|:||||||||..|||||||||||||.||:||.:|
Mouse  1095 RIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSR 1159

  Fly  2460 CHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLL 2524
            .|||||.|.|.|||.:.|.:.|..:...|..|:.|...|::.  ..|||.|:   :||:|::|:|
Mouse  1160 AHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRP--GLGSKTGS---MSKQELDDIL 1219

  Fly  2525 KKGAYGAVMDD--DNAGDKFCEEDI------DSILKR---RTQVITMESE-KG-----STFSKAS 2572
            |.|......|:  |..||....||.      |..::|   |.|..|.::| :|     |:|..|.
Mouse  1220 KFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQ 1284

  Fly  2573 FAA----SGNRSDITID--------DPDFWTKWAKKVDIDPDACERDETEDLV--LSEPRR-RTQ 2622
            :..    .|...::..:        |||:|.|..:.       ....:.|||.  |.:.:| |.|
Mouse  1285 YVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRH-------HYEQQQEDLARNLGKGKRIRKQ 1342

  Fly  2623 IK-RYGHEDVMELNSEESSNEN----SDEEGGIGLRSRRRKEKR-DRAREKKGNDEYIPRERDAL 2681
            :. ..|.::..:...::|.|::    :.|||......|....:| .|...:...|:.:|   ..|
Mouse  1343 VNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLP---PLL 1404

  Fly  2682 AALG--LEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCL 2744
            |.:|  :|.:.: |..:.:.|.  ..::.:|      :.....|...|...|:..
Mouse  1405 ARVGGNIEVLGF-NARQRKAFL--NAIMRYG------MPPQDAFTTQWLVRDLRG---------- 1450

  Fly  2745 QVYKGDEKIKT----FIWDLITPTEDGEV--------QKISRDH----SGLHNLVPR------GR 2787
               |.:::.|.    |:..|..|..||..        :.:||.|    .|:.:|:.:      ..
Mouse  1451 ---KSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHV 1512

  Fly  2788 NGG---------KSNKESTGVSTPAPGSASGSNSGNT---TPAHKSSALDGSDKDSGGINASAVA 2840
            ||.         :.||:.:...:|:|.:.:.|..|:|   |||....|.||...:.
Mouse  1513 NGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEE--------- 1568

  Fly  2841 AAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNT 2905
                     |...::|..:.:                                     :::|...
Mouse  1569 ---------NSLKEEESTEGE-------------------------------------KEVKSTA 1587

  Fly  2906 PISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDD 2970
            |.:.:....||.|  .|::                                   ....|.|..||
Mouse  1588 PEATVECAQPPAP--APAT-----------------------------------APATATAPEDD 1615

  Fly  2971 LAVTSLPINED-----DANSKHDDGDEVDDDGTT----------------TTKDSDSTK------ 3008
            .|....|..|:     :...:.::..|.:..|||                ..:|.:..|
Mouse  1616 KAPAEPPEGEEKVEKAEVKERTEEPMETEAKGTTEVEKVEEKSAVDLTPIVVEDKEEKKEEEEKK 1680

  Fly  3009 ---LTGGDNKDSLLDPERPSSSGKSSSEN-ASGG----NDKTESENDATTVSESSYK-------S 3058
               |..|:....|.|.::..:|.:....| |.||    :...::|..|.||::.:|:       .
Mouse  1681 DVMLQNGETPKDLSDEKQKKNSKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDY 1745

  Fly  3059 EVLPGKGSDLDVSVAQQDALSATPELANTSDP---KMNKNDAQVSASVSCDPADSSSPEAAGKAQ 3120
            .:|.|   .::...|:...:...|..|..::|   :||:.:.
Mouse  1746 WLLAG---IINHGYARWQDIQNDPRYAILNEPFKGEMNRGNF----------------------- 1784

  Fly  3121 GTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNIST 3185
                       |:|:::......:..|   .|..:|                |.....|..|:|
Mouse  1785 -----------LEIKNKFLARRFKLLE---QALVIE----------------EQLRRAAYLNMS- 1818

  Fly  3186 TTTTTTITNTTTTTNNPS--SKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMW 3248
                          .:||  |.|.|:........:.||..| .:||:||:.|
Mouse  1819 --------------EDPSHPSMALNTRFAEVECLAESHQHL-SKESMAGNKP------------- 1855

  Fly  3249 PSMQDLNTRLRRVITAYQRNYKKEELKLQQKA---KLQALVSSTPPLSV---------------- 3294
                 .|..|.:|:.      :.|||....||   :|.|.::..||::|
Mouse  1856 -----ANAVLHKVLK------QLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANR 1909

  Fly  3295 -PTTPTLQSMQMQ 3306
             |..|..|..|.|
Mouse  1910 APEPPPQQVAQQQ 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	0/2 (0%)
		PRK12678	1319..>1500	CDD:237171	28/185 (15%)
		PTZ00121	<1419..1923	CDD:173412	113/580 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	17/74 (23%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	21/90 (23%)
		PLN03142	2029..>2606	CDD:215601	272/618 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd4	NP_001390521.1	CHDNT	164..217	CDD:462357	13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..360		25/127 (20%)
		KIKL. /evidence=ECO:0000250|UniProtKB:Q14839	295..298		0/2 (0%)
		PHD1_CHD_II	372..414	CDD:277006	5/41 (12%)
		PHD2_CHD_II	451..493	CDD:277007	9/43 (21%)
		CD1_tandem_CHD3-4_like	498..576	CDD:349314	19/86 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..537		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..603		6/24 (25%)
		CD2_tandem_CHD3-4_like	619..673	CDD:349309	21/66 (32%)
		PLN03142	724..>1281	CDD:215601	264/571 (46%)
		DEXHc_CHD4	726..957	CDD:350814	110/230 (48%)
		DEAH box	873..876		2/2 (100%)
		DUF1087	1302..1345	CDD:461922	12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1344..1401		10/56 (18%)
		CHDII_SANT-like	1381..1521	CDD:461920	28/164 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1525..1701		38/267 (14%)
		Required for interaction with PCNT. /evidence=ECO:0000250	1577..1922		80/514 (16%)
		CHDCT2	1736..1881	CDD:462358	39/240 (16%)