Protein Alignment kis and chd2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_002933353.2
• Gene: chd2 / 100497210
• XenbaseID: XB-GENE-950755
• Length: 1809
• Species: Xenopus tropicalis
• Alignment Length: 1778
• Identity: 491/1778 - (27%)
• Similarity: 766/1778 - (43%)
• Gaps: 442/1778 - (24%)

  Fly  1536 MLRFSDDENSLLVASPVKKDKKPSANASNSNAGSD----VEKTEPQSGAEGDAAQEVGEEKSNLP 1596
            |:|..|        .|.::|....:|||:.:|..:    |..:|..|.:|.:...|.|.|.::
 Frog     1 MMRNED--------KPGEEDGSAHSNASSHSASEESNHSVYGSESASQSESEHVTEQGSESNS-- 55

  Fly  1597 LDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELI 1661
            ..|||:..:.|...:...|     |..|.|....||                      :.|:|.:
 Frog    56 SSESSESHSESDCESTGSK-----THDALAESKEKP----------------------LPKKERL 93

  Fly  1662 LDKPK--EKAP-------------EPKQDEEKSELDEATTDKP------------------EGDE 1693
            .|..|  |:.|             ||.:...|:|..::.::.|                  :.||
 Frog    94 ADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKAESSDSESESPRRRSMRSTRKKEKNIVSDDEDE 158

  Fly  1694 KFKTEGESKKDLTDSEETKLESSAMEVDSK-EESEPDDSKKS--DEDNKDKDKMEVDDEVGKSDK 1755
                ||.|.:  :|:|:||..||.::...| .:|..:..|:|  .:..|.....|.||:....|.
 Frog   159 ----EGSSAE--SDAEQTKFRSSRLQQKRKLAKSSTNKLKRSLRGKKRKQASSEEEDDDDDDDDD 217

  Fly  1756 ESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKM-EVDEKANDDQSAVSKAEGS- 1818
            :..|:.|:.. :..:|....|:|        |...:.:.::|.: |..|:..|....:.|...|
 Frog   218 DETPKRQTRR-RAAKNVSYKEDD--------DFETDSDDLIEMVGEEAEELEDSHETIEKVLDSR 273

  Fly  1819 -DEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEY 1882
             .:|....::.....||:|.:.             ......|.||:.               ::|
 Frog   274 IGKKGAIGASTTVYATEENGDP-------------NSEFNPETDERE---------------QQY 310

  Fly  1883 FVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDE-------------P 1934
            .:|::.:||:|..|.:|:.|.:...:...|:..|::|:.:.......:..|             .
 Frog   311 LIKWKGWSYIHGTWESEDSLQQQKVKGLKKLENFKKKEEEIKQWLSKVSPEDVEYFSCQQELASE 375

  Fly  1935 FNQDFTEVDRVL------------DMSVHTDETSGETTKHYLVKWKSLPYEDCTWE--------L 1979
            .|:.:..|:||:            |..||:.:||......||.||..|||.:|:||        .
 Frog   376 LNKQYQIVERVIAVKTSKSSSGHSDFPVHSRKTSSSNEPEYLCKWMGLPYSECSWEDGALVGKKF 440

  Fly  1980 EEDVDNDKIEQYLRFN------KIPQRSEWKSKKRPHPELWKKLEKTPVYKGGN--SLRPYQLEG 2036
            :..:|:        ||      ..|.:.....::||.   :..|:|.|.|.||.  .||.|||||
 Frog   441 QHCIDS--------FNCRNNSKTTPVKDCKVLRQRPR---FVTLKKQPSYIGGEGLELRDYQLEG 494

  Fly  2037 LNWLKFSWYNTHNCILADEMGLGKTIQSLTF------VHSVYEYGIRGPFLVIAPLSTIPNWQRE 2095
            ||||..||...::.|||||||||||||:::|      :|.:|     ||||::.||||:.:||||
 Frog   495 LNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHLHLLY-----GPFLLVVPLSTLTSWQRE 554

  Fly  2096 FEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFN 2159
            ||.|. |:|||||.|.:.|:..|::||:.:: :|.|     :|||.|:||:|:::.|...|.:.|
 Frog   555 FEVWAPDINVVVYIGDLGSRNTIREYEWVHQ-QSKK-----MKFNALLTTYEILLKDKAVLSSIN 613

  Fly  2160 WRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFM 2224
            |....:||||||||.:..|.:.|.:.....|:|::||||||::.||:|||:|:.|.:|...|:|.
 Frog   614 WAFLGVDEAHRLKNDDSLLYKTLIEFKSNARLLITGTPLQNSLKELWSLLHFIMPEKFECWEDFE 678

  Fly  2225 SEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSF 2289
            .:.|..| :.....|..:|:|.:|||:|.||||||..|.|.|:.||:..:||:|||.||.:|:..
 Frog   679 DQHGKGR-DNGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMCVMQKQYYRWILTRNYKA 742

  Fly  2290 LKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVL 2354
            |.|||..:. ...:|.:|||:|||.|.:|:...|.:.:....|         .::||.|:||:||
 Frog   743 LSKGTRGST-SGFLNIVMELKKCCNHCFLIKPEETEKESRLDS---------LQSLIRSSGKLVL 797

  Fly  2355 IDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDR 2419
            :||||.:|:..|:||||||||||.||||.:||..:.|||:|:||.|:|.||::|:|.::..||:.
 Frog   798 LDKLLTRLRERGNRVLIFSQMVRMLDILAEYLAIKHYPFQRLDGSIKGELRKQALDHFNAEGSED 862

  Fly  2420 FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREM 2484
            |.|||.|:||||||||.:||||:|:|||||||||||||||.|||||:|.|.||||:.|.|.|.::
 Frog   863 FCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTRGTVEEDI 927

  Fly  2485 FDKASMKLGLDKAVLQSMNTQG-------SKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKF 2542
            .::|..|:.||..|:|.|:|.|       |...|....:|.|:..:||.||  |.:..:..|::.
 Frog   928 IERAKKKMVLDHLVIQRMDTTGRTVLDNNSGSSNCNPFNKDELAAILKFGA--ADLFKETEGEEL 990

  Fly  2543 --CEEDIDSILKRRTQVITMESEKGST--------FSKASFAASGNRSDITIDDPDFWTKWAKKV 2597
              .|.|||.||:...   |.|:|..|:        |..|:||......::.:.....|.
 Frog   991 EPQEMDIDEILRLAE---TRENEPSSSATDELLSQFKVANFATMEEEPEMVLKREQEWD------ 1046

  Fly  2598 DIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRD 2662
            ||.|:. :|.:.|:    |.|::...:.|....:..||.:..:|   |.|..:..:.:.::....
 Frog  1047 DIIPEG-QRKKVEE----EARQKELQEIYMLPRIRSLNKKPQAN---DSESDLESKQKAQRSSGS 1103

  Fly  2663 RAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGW 2727
            .:.....:|:..|:.|....::..:.::                                   |:
 Frog  1104 ESDSDDSDDDKKPKRRGRPRSVRKDNVE-----------------------------------GF 1133

  Fly  2728 RDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGE-VQKISRDHSGLHNLVPRGRNGGK 2791
            .|.::.   |.|..|        :|..:.:..|.....|.| |:|...|...|..|:........
 Frog  1134 TDAEIR---RFIKAY--------KKFASPLERLECIARDAELVEKSVADLKRLGELLHNSCASAM 1187

  Fly  2792 SNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAA-----AVTSIHDPNH 2851
            ...|......||.|...|...|   |..|.|.:.        :|..|:..     .|.|...|..
 Frog  1188 QEFEEQLKENPADGKGPGKRRG---PTIKISGVQ--------VNVKAIIQHEEDFEVLSKSIPAD 1241

  Fly  2852 WSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPP 2916
            ..:|:|::                   |:.||:..::       |....|:|
 Frog  1242 PEEKKKFN-------------------VVSRVKAAHF-------DVEWAIED------------- 1267

  Fly  2917 TPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPIN-E 2980
                           |..||:|.|:||...:..:::||.|             .|:...||:: |
 Frog  1268 ---------------DSHLLLGIYEHGYGNWEHIKSDPEL-------------KLSEKILPVDTE 1304

  Fly  2981 DDANSKHDDGDEVDDDGTTTTKD-------SDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGG 3038
            ....:||          ..|..|       .:..|.||.        .|.|.|..:........|
 Frog  1305 KKPQAKH----------LQTRADYLLKMLKKEMEKETGA--------AEEPKSKKRKPRAKKDSG 1351

  Fly  3039 NDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASV 3103
            ..|.|..||.::...|...||    :|.:      ::|...     .||:..|..|.|
 Frog  1352 KTKDEHGNDISSPRHSDNNSE----EGEE------KEDGTE-----KNTNKKKQKKKD------- 1394

  Fly  3104 SCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDA-PAVEAKKDSAAI--- 3164
                      ....|.:.|..:.||      :.:||..:|:.|...|:| |..:.:|:...:
 Frog  1395 ----------NKENKDKQTQKKEGD------KDKKKAKDKKEKAKRGEAKPGGKNRKNQGPVHIT 1443

  Fly  3165 ARAE----GDKTESCTNNATTNI 3183
            |.:|    |::.|...:..|.:|
 Frog  1444 AGSEPVPIGEEEEDDLDQETFSI 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	87/429 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	13/66 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	19/77 (25%)
		PLN03142	2029..>2606	CDD:215601	266/600 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd2	XP_002933353.2	CD1_tandem_CHD1-2_like	264..346	CDD:349313	19/109 (17%)
		CD2_tandem_CHD1-2_like	379..450	CDD:349308	21/78 (27%)
		DEXHc_CHD2	467..703	CDD:350812	110/250 (44%)
		PLN03142	471..>1005	CDD:215601	260/557 (47%)
		CDH1_2_SANT_HL1	1132..1220	CDD:465731	23/109 (21%)
		DUF4208	1466..1548	CDD:464035	1/1 (100%)