Protein Alignment kis and chd5

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_031761592.1
• Gene: chd5 / 100487004
• XenbaseID: XB-GENE-955461
• Length: 1953
• Species: Xenopus tropicalis
• Alignment Length: 2286
• Identity: 589/2286 - (25%)
• Similarity: 885/2286 - (38%)
• Gaps: 746/2286 - (32%)

  Fly  1394 GGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGD-ETVDSVPDSAGDPASTPSRRDRKRSTARS 1457
            |..|:: |.|         |....||:..|.|||. |.::...:.. .|....|::.::...:::
 Frog     3 GPLGIE-EDP---------IEEMENEEMSEEEAGGMEAINFFAEEL-PPKRKKSKKSKEGKLSKT 56

  Fly  1458 RRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRS 1522
            :|...........:|...|..|:            ||:|.|         ..|...:....|.:.
 Frog    57 KRRKKEGSDADVSENEDELEEKS------------ESEGSD---------YAPNKKKKKKLKEKK 100

  Fly  1523 SRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSA---------------------NASNSN 1566
            .:.|:|||..||     .|:|...:      |:.|.||                     ..:|..
 Frog   101 EKKTKRKKKDDD-----EDNEEGGI------KEPKSSAQLMEEWGLDNVDYAFSEEDYHTLTNYK 154

  Fly  1567 AGSD-----VEKTEPQ---------SGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKER 1617
            |.|.     :.|..|:         .||:.      .|..||.||..||...|:::.:|..|
 Frog   155 AFSQFLRPLIAKKNPKIPMSKMMTVLGAKW------REFSSNNPLKGSSAAAAAAAVAAAVE--- 210

  Fly  1618 QISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELD 1682
              :...|...:.|.|                               :|.:.||          :.
 Frog   211 --TVAVAPPILVSPP-------------------------------QPVQPAP----------IR 232

  Fly  1683 EATTDKPEGD---EKFKTEGESKKDLTDSEETKLESSAMEVDSKEE----SEPDDSKKSDEDNKD 1740
            :|.|.:.:|.   :|.|...:|||.....:.|.|:.....:.||.:    ||.|:.::||.|:..
 Frog   233 KAKTKEGKGPGVRKKSKPSKDSKKKSKVKKMTNLKFKFGGMASKRKKGSSSEEDEREESDFDSAS 297

  Fly  1741 KDKMEVDDEV-------GKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAK-------- 1790
            .:...|..::       ||..|:.|..|:.:..:|:.........:...::..|...
 Frog   298 INSSSVRSDISAGLGKRGKRVKKKKKVEEGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCL 362

  Fly  1791 EPETVLEKMEVDEKANDDQSAV--SKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERV-KEG 1852
            :||.        |||.:.:.:.  .:.||...:..:|...||...|:.:|..:...|..|| |:|
 Frog   363 DPEL--------EKAPEGKWSCPHCEKEGIQWEPKEDDEDEEDGAEEEEEEEDDHMEFCRVCKDG 419

  Fly  1853 EESV-------------------KKENDE-----KTEADMENKPE----------------PVFI 1877
            .|.:                   :..|.|     .|...::.|.:                ||.|
 Frog   420 GELLCCDTCPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWVWREPPPPSGFPVDI 484

  Fly  1878 D--------VE-----EYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFEN 1929
            |        ||     |:|||:...||.||.|..|.:|   :.......|.:|:|         |
 Frog   485 DPLMPPPKPVEGIPEREFFVKWAGLSYWHCSWAKELQL---ELYHTVMFRNYQRK---------N 537

  Fly  1930 IEDEPFNQDFTEVD-----------------------------------RVLDMSVHTDETSGET 1959
            ..|:|...|:...|                                   |:::   |:.:..|:.
 Frog   538 DMDDPPPYDYGSGDEEGKSEKRRNKDPLYAKMEEKFYRYGIKPEWMMIHRIMN---HSFDKKGDV 599

  Fly  1960 TKHYLVKWKSLPYEDCTWELE----EDVDN------DKIEQYLRFNKIPQRSEWKSKKRPHPELW 2014
              |||:|||.|||:.||||::    .|.:|      |..|..|..:..|.|  :|:||....:|.
 Frog   600 --HYLIKWKDLPYDQCTWEIDIIDIPDYENMKQAYWDHRELMLGEDARPLR--FKNKKTKDEKLE 660

  Fly  2015 K-----------KLEKTPVY--KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLT 2066
            |           |.:|.|.|  ..|.:|.||||||||||:|||....:.|||||||||||:|::.
 Frog   661 KPPLAPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIV 725

  Fly  2067 FVHSVYEYG-IRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYK---T 2126
            |::|:|:.| .:||:||.||||||.||:||||.|. :..||.|.|...|:.:|::.|:.::   .
 Frog   726 FLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPEFYVVTYTGDKDSRAVIRENEFSFEDNAI 790

  Fly  2127 ESGK----VLKE-PIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLN 2186
            :|||    :.|| .|||:||:|::|:|..|:..|.:..|...|:||||||||...|....|....
 Frog   791 KSGKKVFRMKKEAQIKFHVLLTSYELITIDHAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYK 855

  Fly  2187 LEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRL 2251
            :::::||:|||||||:.|||.|||||.|.:|::.:.|:.||..:..|:::.||..||.|.|||||
 Frog   856 IDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLDGFLEEFADISKEDQIKKLHDLLGPHMLRRL 920

  Fly  2252 KDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFL-KKGTTSANIPNLMNTMMELRKCCIH 2315
            |.||.|::..|.|.|:.|||:.:|||||:.||.:||..| .||  ..|..:|:|.||:|:|||.|
 Frog   921 KADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKG--GGNQVSLLNIMMDLKKCCNH 983

  Fly  2316 PYLL-----------NGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRV 2369
            |||.           ||:     ||..|            |:.|:||::|:.|:|.|||..||||
 Frog   984 PYLFPVAAVEAPVLPNGS-----YDGNS------------LVKSSGKLMLLQKMLKKLKDGGHRV 1031

  Fly  2370 LIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGIN 2434
            ||||||.:.||:|||:|.|..|.:|||||.|.|.||||||||::.||:.:|.|||.|:|||||||
 Frog  1032 LIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGIN 1096

  Fly  2435 LTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVL 2499
            |..|||||||||||||.||:||.:|.|||||.|.|.|||.:.|.:.|..:...|..|:.|...|:
 Frog  1097 LATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVV 1161

  Fly  2500 QSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNA-------------GDKFCEED----- 2546
            :.  ..|||.|:   ::|:|::|:||.|......||..|             ||....||
 Frog  1162 RP--GLGSKSGS---MTKQELDDILKFGTEELFKDDVEADHNCGTVTIYKKTGDNKDVEDSSVIH 1221

  Fly  2547 -----IDSILKRR------TQVITMESEKGSTFSKASFAASGNRSDITID-------------DP 2587
                 |..:|.|.      |::..| :|..|:|..|.:..   |.:..::             ||
 Frog  1222 YDDAAISKLLDRNQDATEDTEIQNM-NEYLSSFKVAQYVV---REEDGVEEVEREIIKQEENVDP 1282

  Fly  2588 DFWTKWAKKVDIDPDACERDETEDLV--LSEPRR-RTQIK--------RYGHEDVMELNSE---- 2637
            |:|.|..:.       ....:.|||.  |.:.:| |.|:.        :...:|:.:..||
 Frog  1283 DYWEKLLRH-------HYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDDLSDNQSEYSVG 1340

  Fly  2638 -ESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALG--LEEIQYGNWAKSEC 2699
             |..:|:.:|:...|.|..||:.|.||       |:.:|   ..||.:|  :|.:.:.
 Frog  1341 SEDEDEDFEEKPEGGRRQSRRQLKSDR-------DKPLP---PLLARVGGNIEVLGFN------- 1388

  Fly  2700 FKVEKGLLS--FGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLIT 2762
            .:..|..|:  ..||    :.....|...|...|:.
 Frog  1389 ARQRKAFLNAIMRWG----MPPQDAFNSNWLVRDLR----------------------------- 1420

  Fly  2763 PTEDGEVQKISRDHSGL--HNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALD 2825
                |:.:|..|.:..|  .:|...|.:|
 Frog  1421 ----GKTEKEFRAYVSLFMRHLCEPGADG------------------------------------ 1445

  Fly  2826 GSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQ 2890
                                              |:.:.:|..::.|.|  ..||.|:.::..::
 Frog  1446 ----------------------------------AETFADGVPREGLSR--QHVLTRIGVMSLVR 1474

  Fly  2891 HEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPN 2955
            .:| .:|.|.   |...|        |||.:|.|..|..|.|                .:.:|||
 Frog  1475 KKV-QEFEQV---NGKYS--------TPDLIPESVQNKKCFD----------------MVSSDPN 1511

  Fly  2956 LCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVD------DDGTTTTKDSDSTKLTGGDN 3014
                |.|.|..|.....|.::....|..::..||.:.|:      .:...|.|...|.:....::
 Frog  1512 ----TPVAASPAPMPPGVITMAEKCDAQSAMQDDSEMVELKPKYPTEAQPTAKQEKSEQEEINED 1572

  Fly  3015 KD----SLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQ 3075
            .|    .:.|.|:.... :|:.:|:.......|.|.               |.:.|||.|::.:.
 Frog  1573 LDIKEMKIKDIEQDEEK-ESADQNSKAAETHEEQEK---------------PSEKSDLCVTLNKM 1621

  Fly  3076 DALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKD 3140
            :          ..:||..::|               .|:...:.     :|...||.||:.|..:
 Frog  1622 E----------DKEPKTGEDD---------------KPDEKEEC-----ETHQNGENDIKQEDDE 1656

  Fly  3141 NEKETKE-------STGDAPAVE-----AKKDSAAIARA-------------------------- 3167
            .:||.|.       :..|....|     ..::.|||:..
 Frog  1657 GKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAISSGKIYDIWHRRHDYWLLAGIVTHGYARW 1721

  Fly  3168 -------------EGDKTESCTNN-----------------ATTNISTTTTTTTITNTTTTTNNP 3202
                         |..|:|....|                 ....|..........|.|...|:|
 Frog  1722 QDIQNDPRYLILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHP 1786

  Fly  3203 SSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQR 3267
             :.|.|:........:.||..| .:||:||:.|                  .|..|.:|:.
 Frog  1787 -AMALNARLAEVECLAESHQHL-SKESLAGNKP------------------ANAVLHKVLN---- 1827

  Fly  3268 NYKKEELKLQQKA---KLQALVSSTPPLSV-------------------PTTP-TLQSMQMQLQS 3309
              :.|||....||   :|.:::|..||::.                   ||.. |..|.|:....
 Frog  1828 --QLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRGGDPTVQGTFGSSQLYNNF 1890

  Fly  3310 GSGSGGSGIGS 3320
            |....|.|.||
 Frog  1891 GPSFRGPGPGS 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	22/106 (21%)
		PTZ00121	<1419..1923	CDD:173412	121/617 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	24/119 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	23/102 (23%)
		PLN03142	2029..>2606	CDD:215601	278/640 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd5	XP_031761592.1	CHDNT	142..192	CDD:462357	10/55 (18%)
		PHD1_CHD_II	337..379	CDD:277006	6/49 (12%)
		PHD2_CHD_II	412..454	CDD:277007	7/41 (17%)
		CD1_tandem_CHD3-4_like	459..535	CDD:349314	19/78 (24%)
		CD2_tandem_CHD3-4_like	580..634	CDD:349309	18/58 (31%)
		PLN03142	686..>1189	CDD:215601	256/526 (49%)
		DEXHc_CHD5	688..919	CDD:350815	111/230 (48%)
		DUF1087	1263..1316	CDD:461922	12/59 (20%)
		CHDII_SANT-like	1352..1492	CDD:461920	41/277 (15%)
		DUF612	1530..>1665	CDD:282585	32/180 (18%)
		CHDCT2	1698..1843	CDD:462358	27/170 (16%)