Protein Alignment kis and chd1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_031749152.1
• Gene: chd1 / 100485675
• XenbaseID: XB-GENE-960477
• Length: 1797
• Species: Xenopus tropicalis
• Alignment Length: 1829
• Identity: 515/1829 - (28%)
• Similarity: 796/1829 - (43%)
• Gaps: 480/1829 - (26%)

  Fly  1512 DSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEP 1576
            ||..:||...|                .|||:               |.:.|.|::||..:.:..
 Frog     8 DSVSNSNGNSS----------------HSDDD---------------SGSGSGSSSGSSSDGSSS 41

  Fly  1577 QSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGD 1641
            |||:.                |..|..|:.|.:.:...||::        .:.|||..:   .|.
 Frog    42 QSGSS----------------DSESGSESGSQSDSDTSKEKK--------TVQSKPPRL---DGA 79

  Fly  1642 EDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSE---LDEATTDKPEGDEKFKTEGESKK 1703
            |.......:||:   :|..:|.|.:.:..:.:|.::.|.   .||.::...|.||...::.:.||
 Frog    80 EFWKSNPSILAV---QRSAMLRKQQLQQQQQQQRQQASSNSGSDEDSSSSDESDEDSSSDNKKKK 141

  Fly  1704 DLTDSEETKLESSAMEVDSKEESEPDDSKKSDED-NKDKDKMEVDDEVGKSDKESKPEEQSETVK 1767
              ...|:.::..|....||     |..|..||.| ..|:.|....|    |:.:.:|..:.:..|
 Frog   142 --RQDEDWQMSGSGSASDS-----PSASSSSDSDTGGDRQKSSGRD----SESDYEPSHKVKNKK 195

  Fly  1768 TEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNP---- 1828
            ::..|| ::..|:|                   ..:|..|       |:.||:...||.|.
 Frog   196 SQNRSK-VKNGKTS-------------------AGQKKRD-------ADSSDDDYDDDYNKRVSR 233

  Fly  1829 EEATTEKN-KESLEIEGEKERVKE--GEESVKKENDE-------------------------KTE 1865
            .:||...: ||..|::.:.:.:.|  ||:..:.|.||                         ..|
 Frog   234 RQATVNVSYKEDEEMKTDSDDLLEVIGEDVPQPEEDEFETIERVMDSRFGRKGATGGTTTIYAVE 298

  Fly  1866 ADMENKPEPVFIDVEE-----YFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQ-- 1923
            ||  ..|...|.:.:|     |.:|::.:|.:|..|.||:.|.:.:.:...|:..:::|:.::
 Frog   299 AD--GDPNANFNETKEAGETQYLLKWKGWSSIHNTWETEDTLKQQNVKGMKKLDNYKKKEQEKKR 361

  Fly  1924 ------------LNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCT 1976
                        .|..:.:.|: .::.:..|:|::   .|:::.|......|..||:.|||.:|:
 Frog   362 WLKAASPEDIEYYNCQQELIDD-LHKQYQIVERII---AHSNQKSAAGYPDYFCKWQGLPYSECS 422

  Fly  1977 WE---LEEDVDNDKIEQYLRFNK---IPQRSEWKSKKRPHPELWKKLEKTPVYKGGN---SLRPY 2032
            ||   |.......:|::|:..|:   ||.:.....|:||.   :..|:|.|.|.|||   .||.|
 Frog   423 WEDGALIAKKFQARIDEYISRNQSKTIPFKECKVLKQRPR---FVALKKQPSYIGGNKQLELRDY 484

  Fly  2033 QLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVY-EYGIRGPFLVIAPLSTIPNWQREF 2096
            ||:|||||..||...::||||||||||||||:::|::.:: |:.:.||||::.||||:.:||||.
 Frog   485 QLDGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREI 549

  Fly  2097 EGWTD-MNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNW 2160
            :.|.. ||.|||.|.:.|:.||:.:|:.:..      .:.:|.|||:||:|:::.|...|...||
 Frog   550 QIWAPLMNAVVYLGDINSRNMIRTHEWMHPQ------TKRLKLNVLLTTYEILLKDKSFLGGVNW 608

  Fly  2161 RLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMS 2225
            ....:||||||||.:..|.:.|......||:|::||||||::.||:|||:|:.|.:|||.|:|..
 Frog   609 AFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEE 673

  Fly  2226 EFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFL 2290
            |.|..| |.....|...|:|.:|||:|.||||||..|.|.|:.||::..||:||:.||.:|:..|
 Frog   674 EHGKGR-EYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRVEMSASQKQYYKWILTRNYKAL 737

  Fly  2291 KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKS--QHGEDPESYYKNLILSAGKMV 2353
            .|| :..:....:|.||||:|||.|.||:...||...|:.:.  ||          ||.|:||::
 Frog   738 SKG-SKGSTSGFLNIMMELKKCCNHCYLIKPPEENEFYNRQEALQH----------LIRSSGKLI 791

  Fly  2354 LIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSD 2418
            |:||||.:|:..|:||||||||||.||||.:||..|::||:|:||.|:|.:|::|:|.::..||:
 Frog   792 LLDKLLVRLRERGNRVLIFSQMVRMLDILAEYLKSRQFPFQRLDGSIKGEVRKQALDHFNAEGSE 856

  Fly  2419 RFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYERE 2483
            .|.|||.|:||||||||.:||||:|:|||||||||||||||.|||||:|.|.||||:.:.:.|.:
 Frog   857 DFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEED 921

  Fly  2484 MFDKASMKLGLDKAVLQSMNT-------QGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDK 2541
            :.::|..|:.||..|:|.|:|       .||...::...:|:|:..:||.||.....:.:...::
 Frog   922 IIERAKKKMVLDHLVIQRMDTTGKTVLHTGSTPSSSTPFNKEELAAILKFGAEELFKEPEGEEEE 986

  Fly  2542 FCEEDIDSILKRRTQVITMESEKG---------STFSKASFAASGNRSDITIDDPDFWTKWAKKV 2597
            ..|.|||.||||..   |.|:|.|         |.|..|:|:        |:::.|.
 Frog   987 PQEMDIDEILKRAE---TRENEGGPLTVGDELLSQFKVANFS--------TMEEDDM-------- 1032

  Fly  2598 DIDPDACERDET--EDLVLSEPRRRTQIKRYGHEDVMEL-------NSEESSNENSDEEGGIGLR 2653
             ::|:   ||..  ||::.::.|||.: :....:::.|:       |..:.:|.|..|    |.|
 Frog  1033 -VEPN---RDSKSWEDIIPTDQRRRME-EEEREKELQEIYLLPRMRNCAKQANFNGSE----GRR 1088

  Fly  2654 SRRRK-------EKRDRAREKK-GNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFG 2710
            ||.|:       ...||.|.|| |....||||.    ..|..:.:...:.||  :|      .||
 Frog  1089 SRNRRYSGSDSDSMSDRKRPKKRGRPRTIPREN----IKGFSDAEIRRFIKS--YK------KFG 1141

  Fly  2711 W--------GRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDG 2767
            .        .|.:||::..       :.|:.....:|...|::..|
 Frog  1142 GPLERLDAIARDAELVDKS-------ETDLRRLGELIHSGCIKALK------------------- 1180

  Fly  2768 EVQKISRDHSGLHNLVPRGRNGGKSNK------ESTGVSTPAPGSASGSNSGNTTPAHKSSALDG 2826
                   |.||      :.|.||:..|      ..:||...|  ....|:.....|.|||...|.
 Frog  1181 -------DSSG------QERAGGRRGKMKGPTFRISGVQVNA--KLVSSHEDELAPLHKSIPSDP 1230

  Fly  2827 SDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQH 2891
            .::....|.....||     |....|.|::
 Frog  1231 DERKRYVIPCHTKAA-----HFDIDWGKED----------------------------------- 1255

  Fly  2892 EVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNL 2956
                                                    |.:||:|.|::|...:..::.||:|
 Frog  1256 ----------------------------------------DSNLLIGIYEYGYGSWEMIKMDPDL 1280

  Fly  2957 CFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDP 3021
                         :|....||          ||.|:........|:.....||.   |||.|
 Frog  1281 -------------NLTQKILP----------DDPDKKPQAKQLQTRADYLIKLL---NKDLL--- 1316

  Fly  3022 ERPSSSGKSSSENASGGNDK------TESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSA 3080
                  .|.:...:||||.|      .:|:|......|...|||..|....:   |..::|....
 Frog  1317 ------RKEAQRLSSGGNSKRRKTRAKKSKNVKPVKVEEETKSESSPPSSEN---SEEEEDQEET 1372

  Fly  3081 TPELANTS--DPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKD--N 3141
            .|...|..  ..|.|::..::..||:.:|.:..                     :|:..|||  .
 Frog  1373 VPLRTNNKRRAEKENEDRTELDVSVNKEPEEKK---------------------EIKENKKDPKK 1416

  Fly  3142 EKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNI--------STTTTTTTITNTTTT 3198
            ||:.||...|....|| :|...|...|..|.:.......|.:        .:....|.:..|.::
 Frog  1417 EKKEKEEKRDTTEKEA-RDKKEIKTKEPVKEKEIKEEKVTEVKAEKEKPKKSILADTPVHITASS 1480

  Fly  3199 TNNPSSKAA 3207
            ...|.|:.|
 Frog  1481 EPVPISEEA 1489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	95/451 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	21/98 (21%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	16/60 (27%)
		PLN03142	2029..>2606	CDD:215601	262/596 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd1	XP_031749152.1	CD1_tandem_CHD1-2_like	270..354	CDD:349313	16/85 (19%)
		CD2_tandem_CHD1-2_like	387..443	CDD:349308	16/58 (28%)
		PLN03142	464..>1000	CDD:215601	258/553 (47%)
		CDH1_2_SANT_HL1	1123..1208	CDD:477096	22/131 (17%)
		DUF4208	1491..1581	CDD:464035
		U2AF_lg	1669..>1778	CDD:273727
		HisXaaSer_A3	<1705..1744	CDD:439608