DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and chd8

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:XP_012812626.1 Gene:chd8 / 100192376 XenbaseID:XB-GENE-966847 Length:2335 Species:Xenopus tropicalis


Alignment Length:3377 Identity:1004/3377 - (29%)
Similarity:1390/3377 - (41%) Gaps:1197/3377 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1007 DLQEKPTAEMEQTQLGQSLGDLSKSLLEEPKTVEESGEDKSQSAPGVAPPADPIIPVTQPPQQQM 1071
            ||.:.|......:..|.|.|              ..|.|....|.|:.....|:.|:|.      
 Frog     7 DLFDDPNLFGLDSLTGDSFG--------------RDGPDTIDDALGLGNVLGPLEPITD------ 51

  Fly  1072 PPIGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPG 1136
             .:|:|...:. ..|.:.|.:..:.|..|....|               ..:.|.||    :|..
 Frog    52 -RVGLPGADVG-NNEVKQQTESQVLPDNPALMSA---------------TEIMQPIQ----LPTN 95

  Fly  1137 HELQHQ------------DKLMRMQ------------ERLNLLTQHEVNDQCAGGPQCLLFQNVP 1177
            .|..:|            .|:|.::            .::..||.|    |.|.|.: :.|..| 
 Frog    96 QETLNQGNPFMGASNAGAPKIMILKAPAGMTVGACPVTQIQTLTPH----QAANGGK-VAFAKV- 154

  Fly  1178 PMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVG-----QQQDLMDISG 1237
                ..|.||       .|.||..:|       |.........|...|||     :|..|..:..
 Frog   155 ----LTGTPL-------RPGVSIVSG-------NTVLAKMPSTGVAGQVGAVRPVRQLLLQPVRA 201

  Fly  1238 NVAMGAANAVS----SIPTTQLPVSED--CVTQGAGDTSVVGMLEYSEG-----MGDL-SQDVHS 1290
            :.|.|::.:.:    :|..|..|...|  .:|......|.||... .:|     :|.| .:.|..
 Frog   202 SAAPGSSESNTGIKPAITLTSAPQQGDPKRITLVLQQPSQVGATA-QQGQRHVVLGGLPGKIVLQ 265

  Fly  1291 ANELDTSTDGSGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNST--------ETPAAVKK 1347
            .|:|...|          :.:||:  .:|.:..|.:.:..:.|.....|        :.|..| .
 Frog   266 GNQLAALT----------QAKTPQ--GQPAKVVTIQLQVQQQPGAAGQTPQKFQIVQQAPGGV-A 317

  Fly  1348 RAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAE---------------------- 1390
            .|.:.:......:.|.::.....:|    .|.|:|||:.|.|:                      
 Frog   318 IAPSGQHTHMLNQQGVQRLSVPLKV----VLQPQAGSSQGTAQGLSVVKVLNASEVANLTASQTV 378

  Fly  1391 --TTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEA-----GDETVDSVPDSAGDPASTP--- 1445
              |::||    |||...|.   .|....:|....||.|     |::.:..|.:....|:..|   
 Frog   379 VKTSTGG----GESRKLDS---QKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVNPEDD 436

  Fly  1446 --SRRDRKRSTARSRRNANSEE------GGSAR---KNRGSLSAKALKKRRNRGRIVPESDGEDD 1499
              |||.||:....:...:..|:      .||.|   |.:.|.....:.|:|.|.   |.||..|.
 Frog   437 DGSRRKRKKKKGETSDRSKDEKPKKVKGSGSLRSRSKGKPSTITPIVGKKRKRN---PSSDNSDA 498

  Fly  1500 TLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDEN--SLLVASPVKKDKKPSANA 1562
            .:  ....:.|.:.|....||||:|..:||||.:|:.::.:|||:  .:.|..||          
 Frog   499 EI--MASQASPAEDEDSVQKRRSNRQVKRKKYTEDLDIKITDDEDDEEVDVTGPV---------- 551

  Fly  1563 SNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAA 1627
                      ||||....|            .:||.:|   ||..|.....|             
 Frog   552 ----------KTEPVLLPE------------PMPLPDS---EAVPSMQFFVE------------- 578

  Fly  1628 MSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGD 1692
                      |..:||:.:|..:|:||:.|:||                            |.|:
 Frog   579 ----------NPSEEDAAIVDKILSMRLAKKEL----------------------------PTGE 605

  Fly  1693 EKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKES 1757
                                                                             
 Frog   606 ----------------------------------------------------------------- 605

  Fly  1758 KPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKS 1822
                                                                             
 Frog   606 ----------------------------------------------------------------- 605

  Fly  1823 TDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYR 1887
                                                                 :::||||||||:
 Frog   606 -----------------------------------------------------YVEVEEYFVKYK 617

  Fly  1888 NFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHT 1952
            |:|||||||.|.|: |:.|:|:..|::||:.|.:|..:..:. ::|.||.|:.||||:||.|..|
 Frog   618 NYSYLHCEWATIEQ-LERDKRIHQKLKRFKTKMTQMQHFLQE-DEESFNPDYVEVDRILDESHST 680

  Fly  1953 DETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKL 2017
            |:.:||...:|||||.||||||.||||:||||:.|||::.|..  .::...|...||....||||
 Frog   681 DKDNGEPVVYYLVKWCSLPYEDSTWELKEDVDDGKIEEFKRIE--ARQPNLKRVARPAATSWKKL 743

  Fly  2018 EKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLV 2082
            |.:..|:.||.||.|||||:|||.|:|||..||||||||||||||||:||:..||..||||||||
 Frog   744 ELSREYQNGNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSITFLQEVYNVGIRGPFLV 808

  Fly  2083 IAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEM 2147
            |||||||.||:|||..||.||.:|||||:.|:||||.||.|.|...|:::....||:.|||||||
 Frog   809 IAPLSTITNWEREFGSWTQMNTIVYHGSLASRQMIQQYEMYCKDSKGRLIPGAYKFDALITTFEM 873

  Fly  2148 IVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFL 2212
            :::|..:|:...||..:|||||||||||||||:.|:.::|||:|||:||||||.:.||||||:||
 Frog   874 VLSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFL 938

  Fly  2213 EPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKK 2277
            ||:||||:.||:.:||.|:|||:|.||||:||||||||||:||||:||||:||||||||||||||
 Frog   939 EPTQFSSEAEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKK 1003

  Fly  2278 YYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYY 2342
            |||.|||:|||||.||.:.:|.|||:||||||||||.||||:.||||:|..:|:......|..::
 Frog  1004 YYRAILEKNFSFLTKGASQSNTPNLLNTMMELRKCCNHPYLITGAEEKIISEFREATPVVPPDFH 1068

  Fly  2343 -KNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQ 2406
             :.::.|:||:||||||||||:|.||:||||||||||||||||||:.|:|.:||||||:|||:||
 Frog  1069 VQAMVRSSGKLVLIDKLLPKLRAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNMRQ 1133

  Fly  2407 EAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKI 2471
            .||||:|:|.||||||||||:|||||||||||||.||:|||||||||||||||||||||.|.|||
 Frog  1134 AAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKI 1198

  Fly  2472 YRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSK-DGNNKQLSKKEIEDLLKKGAYGAVMDD 2535
            |||:.||:||||||||||:||||||||||||:.:.:. .|..:|.:||||||||:||||.|:||:
 Frog  1199 YRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDNHLSGPIQQFTKKEIEDLLRKGAYAAIMDE 1263

  Fly  2536 DNAGDKFCEEDIDSILKRRTQVITMESE-KGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDI 2599
            |:.|.||||||||.||.|||..||:||| ||||||||||.||.||:||::|||:||.|||||.|:
 Frog  1264 DDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFSKASFVASENRTDISLDDPNFWQKWAKKADL 1328

  Fly  2600 DPDACERDETEDLVLSEPRRRTQIKRYGH--EDVMELNSEESSNENSDEEGGIGLRSRRRKEKRD 2662
            |.|......|  ||:..||.|.|.:.:.:  :|::|.:..||.:::           |.:..::|
 Frog  1329 DLDLLSSKNT--LVIDTPRIRKQTRHFTNKDDDMVEFSDLESDDDD-----------RPKARRQD 1380

  Fly  2663 RAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGW 2727
            |   |.|                     ||   :::||:|||.||.:|||||.::|..|:||||.
 Frog  1381 R---KHG---------------------YG---RTDCFRVEKHLLVYGWGRWRDILTHGRFKRGM 1418

  Fly  2728 RDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKS 2792
            .:.|||...|.||:|||..|:|||.||:||||||||.|:|:.::: ::||||...|||||.|.|.
 Frog  1419 NERDVEKICRAILVYCLLHYRGDENIKSFIWDLITPAENGKTKQL-QNHSGLSIPVPRGRKGKKV 1482

  Fly  2793 NKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEK 2857
            ..:|                  :...||:.                             |.  .|
 Frog  1483 KSQS------------------SFDIHKAD-----------------------------WI--HK 1498

  Fly  2858 YDADA-YLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPD-Q 2920
            |:.|. :.:..|||||....|||||||||||:::.||||:...::.......::.|..|.... :
 Frog  1499 YNPDTLFQDEGYKKHLKHQCNKVLLRVRMLYFLRQEVIGNQAMKVLSGVEARQIDIWFPQVDQVE 1563

  Fly  2921 VPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANS 2985
            |||.||:.. .|||||:|.:|||.|.|..|||||.|||:..||   ..|:.|:.        |..
 Frog  1564 VPSRWWDRE-ADKSLLIGVFKHGYEKYNTMRADPALCFLEKVG---GPDEQAIA--------AEH 1616

  Fly  2986 KHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPE-RPSSSGKSSSENASGGNDKTESENDAT 3049
            ...|..|:.|               |||....:.||| :|..:.|                    
 Frog  1617 HAQDFSELPD---------------GGDFDRDIEDPEYKPLHAQK-------------------- 1646

  Fly  3050 TVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPE 3114
                                                                    ||.|     
 Frog  1647 --------------------------------------------------------DPED----- 1650

  Fly  3115 AAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNA 3179
                            |:|                                              
 Frog  1651 ----------------EID---------------------------------------------- 1653

  Fly  3180 TTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDA 3244
                                                     .|.:|||.||...        |:|
 Frog  1654 -----------------------------------------SLMMDEEISVVDG--------EEA 1669

  Fly  3245 TTM-----WPSMQDLNTRLRRVITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQ 3304
            |.|     ||....|..||||:||||||:||:|:|||:                           
 Frog  1670 TAMPSGMLWPPGSALTARLRRLITAYQRSYKREQLKLE--------------------------- 1707

  Fly  3305 MQLQSGSGSGGSGIGSSAQHDASGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGGAG 3369
                                                         |...|.              
 Frog  1708 ---------------------------------------------AEERGD-------------- 1713

  Fly  3370 VMPAMPTAADISLMLSILNTTDVNQLANLDINKLAMYLVSMNNKMERQGKMELAAKERESQRLQL 3434
                                                         :|:.:.|.|.|.:|..|.:.
 Frog  1714 ---------------------------------------------KRRKRCEAAFKLKEIARREK 1733

  Fly  3435 IPKKWNRREEYEFLRVLTGYGVDLHVSTPMASSNGSSLSPDWTKFKQMAHLERKSDETLTDYYKV 3499
             .::|.|||..:|.|||:.:||:....|.:.         ||.:|:.:|.|::|:||:|..|:..
 Frog  1734 -QQRWTRREACDFFRVLSSFGVEYDPDTQLY---------DWQRFRGLARLDKKTDESLLKYFHG 1788

  Fly  3500 FVAMCKRQAGLKLSESERGLEG--IIEEIEKEHAKLILDRLEVLAKLRE-VARNPMLEERLKLCT 3561
            |||||::...|..:..:...:.  .||.|.:|.|...|.||::|.::|| |..:|:|..||.||.
 Frog  1789 FVAMCRQVCRLPPAAGDEPPDPSLFIEPISEERASRALFRLDLLRRVREQVLCHPLLIPRLSLCR 1853

  Fly  3562 KNADTPDWWEPGRHDKELITAVLKHGLYRSETFIFNDPNFSFGESEKRFIRELEAQI----QRTI 3622
            .:.:.|:|||.||||.||:....::||.|::..|..|..|||          |..||    .|.|
 Frog  1854 PDPELPEWWESGRHDNELLQGAARYGLSRTDLTILQDHAFSF----------LRCQISYFQSRGI 1908

  Fly  3623 KLEAFNAEKAEKLAAAEKDAATEKAAATEKAAAEKAASVKNEVIDLDDELMTNESVIKKESPVTP 3687
                                    :..:..:....|.||..|               ::.|.:..
 Frog  1909 ------------------------SGHSRPSTPTTAPSVPTE---------------RQPSHLAS 1934

  Fly  3688 IKEEIKSEESPEKHDT------ADNLEDKNSDAEESTKIKGKEDFNPETTEKEALDESTNLN--- 3743
            :...:....:|.:..:      :.|.|| :||.....|:|.    |...:.....||.:.|:   
 Frog  1935 LSSSVSCSPAPRRSSSCSSSSHSSNSED-SSDESNGVKVKP----NAGLSHARLYDEESRLSLTA 1994

  Fly  3744 --KDKSSTETLVPEIEDSKPSE---DKM---EVEELPVAENGEKEGSPEKCSDAEDKKFSEEKPS 3800
              .|.::.:::...:|....::   |::   .:|::..|....|..||.:.||..    |:...|
 Frog  1995 SPADLTTEDSIQTALETPHSTDWPKDRVLICRIEQVCSAVLTGKWSSPRRLSDPP----SDSPDS 2055

  Fly  3801 SPAVPDGK-VSEMEADEAAPNTEENCSGDSESPEKECEDKVVEKVEEEKGENSYEKAEEQKEETE 3864
            .|..|:.: .:.......||:.:|                ...:::.|:|    .|.:.||.:. 
 Frog  2056 LPPTPEQQSPAHFTQIRPAPDPKE----------------FTIQIKSEEG----LKIKFQKHKF- 2099

  Fly  3865 KLEKSSIESEPSEKSETVLEPEVAVPKKSTGDQDILDLVAGPSDPDDDEVMKEKEKAVEEECKKQ 3929
             :...:::|.|                                     ...|:|.|      ||.
 Frog  2100 -MGNGALDSAP-------------------------------------HTQKKKSK------KKM 2120

  Fly  3930 AAELKARFPDLEVIQPATVKQQK------LEKPKLEMCMIRWF---KDFALERRIAHIVACVESG 3985
            ..::..|.|         |..||      .|:..|...:..|.   .||.::.|   .:|.:|..
 Frog  2121 DLDMDTRIP---------VVNQKDGTLLLGEEAPLRCQLPEWLHRNPDFMVDPR---FIAFMEDR 2173

  Fly  3986 NWPVDSKYSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTKHLQTSHMQQVA 4050
            .     |.....:.|..:...|...:: ||..:.::.|.|.:...       |:||.|:..::  
 Frog  2174 R-----KRKKHRSKKSKSSSQIGNVQN-PHSHNGKKSSHTENSFE-------TQHLPTAAKKR-- 2223

  Fly  4051 SSASAASTSSGVPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLP---GMS 4112
                            :.:|.|...:|.              |...||....|.|.|.|   |..
 Frog  2224 ----------------KKRPPSKIIMPS--------------ALHGAGDVTHSFSDLQPDHSGHP 2258

  Fly  4113 LSAATGSSAGGVS---GLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAPKDWESEIA 4174
            :.:..|.|.||:|   ||      ||:|..|              .|:...||.           
 Frog  2259 MRSVYGPSDGGLSHQAGL------SGLGFTR--------------FHSSQTSSV----------- 2292

  Fly  4175 NMEALSGSSGRGRGGNSSASSGMQPPPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMGAPMD 4236
                     ||..|.........:||  .||.||       ...|.:||..:   |.|..:|
 Frog  2293 ---------GRIHGTTFDELQSFEPP--QQHFSL-------LDDPMMPANSS---SSGDELD 2333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 24/231 (10%)
HepA 1676..2527 CDD:223627 428/852 (50%)
SDA1 <1693..>1854 CDD:283052 0/160 (0%)
CHROMO <1879..1919 CDD:237991 24/39 (62%)
Chromo 1941..1996 CDD:278797 34/54 (63%)
DEXDc 2048..2197 CDD:238005 95/148 (64%)
Helicase_C 2350..2464 CDD:278689 95/113 (84%)
RR_TM4-6 3728..>3877 CDD:283990 27/160 (17%)
BRK 4569..4613 CDD:197800
chd8XP_012812626.1 Med15 35..>363 CDD:312941 77/396 (19%)
CD1_tandem_CHD5-9_like 582..647 CDD:349315 35/276 (13%)
CD2_tandem_CHD5-9_like 665..723 CDD:349310 35/57 (61%)
PLN03142 754..>1357 CDD:215601 414/604 (69%)
DEXHc_CHD8 755..976 CDD:350818 147/220 (67%)
BRK 2123..2165 CDD:400080 10/50 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 564 1.000 Domainoid score I232
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1491 1.000 Inparanoid score I105
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001075
OrthoInspector 1 1.000 - - otm47615
Panther 1 1.100 - - O PTHR45623
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3575
SonicParanoid 1 1.000 - - X648
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1010.090

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