DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Usp6nl

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_852064.2	Gene:	Usp6nl / 98910	MGIID:	2138893	Length:	842	Species:	Mus musculus

Alignment Length:	390	Identity:	96/390 - (24%)
Similarity:	159/390 - (40%)	Gaps:	98/390 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NNLPDRQR---VERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYL 390
            |...|||:   :||     .::||:......|..::.:....|::|..:| ||.|||..||
Mouse    83 NAAADRQKQLEIER-----TSKWLKMLKKWERYKNTEKFHRRIYKGIPLQ-LRGEVWALLL---- 137

  Fly   391 WSDTHVERIERRKQKSIEYYN-MKAQWLAMTTTQEANFCGYRERKC-----QIEKDVKRTDRSLQ 449
                   .|.:.|:::.:.|: :|                :|.|.|     ||:.||.||.|...
Mouse   138 -------EIPKMKEETRDLYSKLK----------------HRARGCSPDIRQIDLDVNRTFRDHI 179

  Fly   450 FFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNF 514
            .|..........|..:|..|.:||.::||.||||.:.| :|.:.:||.|.||..|..       |
Mouse   180 MFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKL-------F 236

  Fly   515 DIDQAGMKTQFAQ-IRRLIEFAN------APLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDV 571
            ...:..|...|.| ..:|:.|..      ....:.::.| ||..:|..| :.:.|:
Mouse   237 SGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSF-YTMKWF--------- 291

  Fly   572 LKLWECLWTRLPCPNFHL---LFSVAILDQETRVIIDSQYEFTEI-LKHVNELSGNIDVQKTLQV 632
               ::|...|.|   |.|   ::.:.|.:.| ||:....|...:: .||:.:||    :::.::
Mouse   292 ---FQCFLDRTP---FRLNLRIWDIYIFEGE-RVLTAMSYTILKLHKKHLMKLS----MEELVE- 344

  Fly   633 AEGIYLQLKGSETLPNDI---RSIIGEPLLPAAAGEEIDGGMVD-EEPTYSDDGFDELVKELTPE 693
                :||    |||..|.   ...:.|.|..:.|  |:....:| .||...|:...:.:.:|.||
Mouse   345 ----FLQ----ETLAKDFFFEDDFVIEQLQVSMA--ELKRAKLDLPEPGKEDEYPKKPLGQLPPE 399

Fly 694 693
Mouse 400 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	61/245 (25%)
Usp6nl	NP_852064.2	TBC	120..335	CDD:214540	68/267 (25%)
Usp6nl	NP_852064.2	SPRR2	<590..642	CDD:291486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810