DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and USP6NL

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006717605.1	Gene:	USP6NL / 9712	HGNCID:	16858	Length:	856	Species:	Homo sapiens

Alignment Length:	310	Identity:	78/310 - (25%)
Similarity:	125/310 - (40%)	Gaps:	69/310 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 LPDRQ-RVERGHPL---TETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLW 391
            |||.. .|||...|   ..|:||:......:..::.:....|::|..:| ||.|||..||
Human    84 LPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQ-LRGEVWALLL----- 142

  Fly   392 SDTHVERIERRKQKSIEYYN-MKAQWLAMTTTQEANFCGYRERKC-----QIEKDVKRTDRSLQF 450
                  .|.:.|:::.:.|: :|                :|.|.|     ||:.||.||.|....
Human   143 ------EIPKMKEETRDLYSKLK----------------HRARGCSPDIRQIDLDVNRTFRDHIM 185

  Fly   451 FAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFD 515
            |..........|..:|..|.:||.::||.||||.:.| :|.:.:||.|.||..|..       |.
Human   186 FRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKL-------FS 242

  Fly   516 IDQAGMKTQFAQ-IRRLIEFAN------APLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVL 572
            ..:..|...|.| ..:|:.|..      ....:.::.| ||..:|..| :.:.|:
Human   243 GPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSF-YTMKWF---------- 296

  Fly   573 KLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEI-LKHVNELS 621
              ::|...|.|......::.:.|.:.| ||:....|...:: .||:.:||
Human   297 --FQCFLDRTPFTLNLRIWDIYIFEGE-RVLTAMSYTILKLHKKHLMKLS 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	59/242 (24%)
USP6NL	XP_006717605.1	TBC	125..340	CDD:214540	66/264 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810