DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and USP6

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001291213.1	Gene:	USP6 / 9098	HGNCID:	12629	Length:	1406	Species:	Homo sapiens

Alignment Length:	194	Identity:	43/194 - (22%)
Similarity:	83/194 - (42%)	Gaps:	39/194 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 DSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLR 378
            ::||..:.|::.|.:     |:.:.|     .::|:|..........|:::.:.::: |:..::|
Human    53 ETELPPVTAREAKKI-----RREMTR-----TSKWMEMLGEWETYKHSSKLIDRVYK-GIPMNIR 106

  Fly   379 PEVWKFLLNYY---LWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKD 440
            ..||..|||..   |.:....:.::.|.::|.|:.:                        .|:.|
Human   107 GPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIH------------------------HIDLD 147

  Fly   441 VKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFV 504
            |:.|.|:..||..........|..||:.|..||.::||.:.:|.:.|..| :.:.|.|.||..|
Human   148 VRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFL-LYLPEEDAFWALV 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	34/139 (24%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540	34/140 (24%)
		DUF4607	<332..407	CDD:292024
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..380
		UBP12	<528..1114	CDD:227847
		Peptidase_C19	533..>723	CDD:271592
		Peptidase_C19	<1023..1367	CDD:271592
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810