DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and GYP5

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_015075.1	Gene:	GYP5 / 855827	SGDID:	S000006170	Length:	894	Species:	Saccharomyces cerevisiae

Alignment Length:	831	Identity:	162/831 - (19%)
Similarity:	284/831 - (34%)	Gaps:	229/831 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QVQLGVFNESQLSSVEEDVQNLPQQGTGNILF-----THDGVLL--KKASAEHIADLNTS----- 64
            :|..|..:.:.|.|:||::::.|......|..     .|....|  |:.|..|.|..|.|
Yeast    17 EVHEGDNHSNNLGSMEEEIKSTPSDQYEEIAIIPTEPLHSDKELNDKQQSLGHEAPTNVSREEPI 81

  Fly    65 -----GSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRA 124
                 ....:.|.:.:......|....|...|:.:.:..|                  .|::.:|
Yeast    82 GISGDEDTQITEQNVNEQRQETREPSSEIDLNEPLDVEKD------------------VTTDVQA 128

  Fly   125 FNTRPIEPSGGATTRSRVMRAQLED-LSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVR 188
            .|...||....|...:..:.|..:: :||.|.|.    :.....|.....|..|....:......
Yeast   129 PNGLNIEKEYDAVKENEKVYADTKEVVSSPENRE----VTGKNSGGEKSSSSKFLDDESGTTTAA 189

  Fly   189 SMRDQHLIENAETSRSG----------GEVYA-ILTTENQKLKKTFAELDIGQIKASQLPRESW- 241
            :..|..:.......||.          .||.| |...||::.|   |.::.|.:.|..|..|:.
Yeast   190 NANDISISSEVTPERSSENDNNQIHITNEVAAGINLNENKEQK---AAIEDGPVTAENLSSETAR 251

  Fly   242 ----LPNKLAGILGN---------IPDYVQPPF---------------------QRSPKSRPGV- 271
                :|.::....|:         ||....||.                     ::.||::..|
Yeast   252 KVPPIPTQIINEKGDNSSENEVSAIPTTSSPPLPPRQNVATSTSPKLPPRGKQREQPPKTKNAVP 316

  Fly   272 -----------LISGDRQTSPDNYQIIGLSGSTNSACSSNGQ----------------------- 302
                       ......:|..::|..:.|:||..:...|..:
Yeast   317 PPLEEEMKSEKFRKNFEETKRNSYHHVPLTGSKTAQLESTAEINLIASRYRKTSHHLNKEGEETR 381

  Fly   303 ---SRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARI 364
               ..|.|..||...|.||.|:..:|  |.|:.:..|     .:.:..| .|.|.  .::|.|.:
Yeast   382 ESLQEGQSFLKSTFTSFLENLSEYNE--VENVNEEDR-----EMFKIDW-SFWTQ--VVNDYATV 436

  Fly   365 K-------ELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTT 422
            .       |.....|:...:|..:|:.:.|                .||.|..::....|.....
Yeast   437 ASNEPENLEAHVTNGIPPQIRGIIWQLMAN----------------SKSREMEDIYETLLDTECL 485

  Fly   423 QEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLA 487
            .||.          |.:|::||.     |..||  .:..|..::..|.:|:.|:||.|||..:.|
Yeast   486 HEAT----------IRRDLRRTK-----FVAED--KMESLYKVIKVYSVYDPDVGYTQGMGFIAA 533

  Fly   488 PILEIQVNEVDTFWCFVGFMELVFTNFDIDQ------AGMKTQFAQIRRLIEFANAPLFN-YMRS 545
            |:|....||.::|...||.|:    |:.:.:      .|:.....|..||:|..:..|:| .:|.
Yeast   534 PLLINCENEAESFGLLVGLMK----NYGLRELFLPGMPGLMLMLYQFDRLLEEHSPSLYNRLIRE 594

  Fly   546 HDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAI----LDQETRVIIDS 606
            ..|..|| ..:|.|.::..:...|.||::::.::..    ...:|...|:    .::||.|
Yeast   595 GISSTMY-ATQWFLTFFAYKFPLEFVLRIFDIVFVE----GIEVLLKFAVNLMLKNEETLV---- 650

  Fly   607 QYEFTEILKHVNE------LSGNIDVQKTLQVAEGIYLQLKGSE--TLPNDIRSIIGE------- 656
            :..|.|:|..:.:      |.||.|....:|:........||::  |...::...:.:
Yeast   651 KLRFDELLDFLKDELFNYYLMGNQDDASVVQMGLSNGNSFKGNDDGTFSYNVDLFVHDAMTGVYI 715

  Fly   657 -PL-LPAAAGEEIDGGMVDEEPTYSDDGFDELVKELTPEEKVRQQALLEEA 705
             || |....||.::   :.|:....:|.::.|        :::...|..||
Yeast   716 TPLTLRRYRGEYVE---IHEKEQKKEDHYESL--------RIQNHQLQREA 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	28/171 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	54/239 (23%)
GYP5	NP_015075.1	COG5210	154..737	CDD:227535	129/648 (20%)
GYP5	NP_015075.1	SMC_prok_B	726..>891	CDD:274008	7/41 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810