DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and GYL1

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_013917.1	Gene:	GYL1 / 855230	SGDID:	S000004804	Length:	720	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	143/782 - (18%)
Similarity:	260/782 - (33%)	Gaps:	280/782 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EMPRRRLLLEWQP---NDSIMIADD-SQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATT 138
            |:||..  .:.||   :|.|.:.|: |..:||.                :|::...:|.   |||
Yeast    13 EVPRTP--HQTQPEKDSDRIALRDEISVPEGDE----------------KAYSDEKVEM---ATT 56

  Fly   139 RSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETSR 203
            .:.      .:..|.|....|::|     ||        |.:.:..|....:|::   ..::|..
Yeast    57 NAS------SNFGSNESAKDGESI-----GA--------FSNPHEALMQSKLREE---SQSKTIL 99

  Fly   204 SGGEVYAILTTENQKLKKTFAEL---------DIGQIKASQLPRESWLPNKLAGILGNIPDYVQP 259
            ...::...|.||..|:::....:         |..:..||.|  :|.||..||   ||..|  |.
Yeast   100 PSDDLSQQLETEESKVEEALKRITSPPLPPRADCIEESASAL--KSSLPPVLA---GNKND--QA 157

  Fly   260 PFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSR--GGSAEKSP---------- 312
            |..| |:..|..::         |.:.:.|.....:|..|...:.  |.|:..:|
Yeast   158 PLDR-PQLPPRQVV---------NAETLHLKAPHGNATPSKSPTSAVGNSSSSTPPTLPPRRIED 212

  Fly   313 ------------------------------ADSELETLN-AQDEKIVNN--LPDRQRVERGHPLT 344
                                          .|.:...|| .:|.|.:||  :|:.         .
Yeast   213 PLDLAAQKHFLASTFKRNMLFYKSEDNSIKCDLDKNILNLKEDSKKINNNEIPEE---------V 268

  Fly   345 ETQWL----EFQTPDGRISDSARIKELIFR--GGVVQSLRPEVWKFLLNYYLWSDTHVERIERRK 403
            .:.||    ::|  :..|:|   |:.|.|:  .|:..:.|..||: |::|             .|
Yeast   269 SSFWLKVIGDYQ--NILIND---IETLHFQLSRGIPAAYRLVVWQ-LVSY-------------AK 314

  Fly   404 QKSI----EYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQG 464
            .||.    |.|          .|:.|.|            ||:..:..|:......:..:..:..
Yeast   315 SKSFDPIYETY----------LTEMAPF------------DVQEFENQLKMMDEVPSEYVKRISN 357

  Fly   465 ILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFA--- 526
            :|..|::::.:..:...::.::..||::...|.:.|...|..|::.         |::..|.
Yeast   358 VLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVY---------GLRLLFLPSA 413

  Fly   527 --------QIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSE------DVL----- 572
                    :..||:|.....:.|:|......:..|...:....::::|.:|      |::
Yeast   414 SEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGI 478

  Fly   573 -KLWECLWTRLPCPNFHLL------------------------------------FSVAILDQET 600
             .:...|.|.|.....|||                                    ....:.|...
Yeast   479 DSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMM 543

  Fly   601 RVII--------DSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEP 657
            :|.|        .|:||      .::.|....:||......:.::|| |....|.||..|:..|.
Yeast   544 KVAITPKTMKKYSSEYE------EIHRLDNEKEVQYKSITEKNLHLQ-KHVRKLENDYTSLNREH 601

  Fly   658 LLPAAAGEEIDGGMVDEEPTYSDDGFD----ELVKELTPEEKVRQQAL-----------LEEACE 707
            :  ..|.|.:...:..|.....::|:.    :|.|:|..|:|  :|.|           |||..:
Yeast   602 V--TIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKK--KQVLGVYVPNDLKKDLEETMK 662

  Fly   708 RS 709
            ::
Yeast   663 KN 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	24/116 (21%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	43/293 (15%)
GYL1	NP_013917.1	COG5210	27..569	CDD:227535	114/664 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810