DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D10A

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001191169.1	Gene:	TBC1D10A / 83874	HGNCID:	23609	Length:	515	Species:	Homo sapiens

Alignment Length:	466	Identity:	96/466 - (20%)
Similarity:	165/466 - (35%)	Gaps:	123/466 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 RSPKSRPGVLISGDRQT---SPDNYQIIGLSGSTNSACSSNG-------------QSRGGSAEKS 311
            |:|.:  |..:||.|::   .||......|| |..|...:||             .|:|  ||.:
Human    11 RAPAA--GESLSGTRESLAQGPDAATTDELS-SLGSDSEANGFAERRIDKFGFIVGSQG--AEGA 70

  Fly   312 PA-------DSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLE-FQTPDGRISDSARIKELI 368
            |.       :..||.|             |||        |::||: ....|..::...:...|.
Human    71 PCPLLHRLEEVPLEVL-------------RQR--------ESKWLDMLNNWDKWMAKKHKKIRLR 114

  Fly   369 FRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQK--SIEYYNMKAQWLAMTTTQEANFCGYR 431
            .:.|:..|||...|::|      |...| ::::...|  .::......:||.:
Human   115 CQKGIPPSLRGRAWQYL------SGGKV-KLQQNPGKFDELDMSPGDPKWLDV------------ 160

  Fly   432 ERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNE 496
                 ||:|:.|.....:.|..........|..:|..|.:|..:.||.|..:. :|.:|.:.:..
Human   161 -----IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAP-IAAVLLMHMPA 219

  Fly   497 VDTFWCFVGFMELVFTNF-----DIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFR 556
            ...|||.|...|.....:     :..|...:..|:.::::...|:    .::.....|.:.:...
Human   220 EQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAH----KHLSRQKIDPLLYMTE 280

  Fly   557 WLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAIL-------DQETRVIIDSQYEFTEIL 614
            |.:..:.|.|....||::|:..:    |....::|.|.::       ..|.......|||..|.|
Human   281 WFMCAFSRTLPWSSVLRVWDMFF----CEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERL 341

  Fly   615 KHVNELSGNIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDG---------- 669
            :   .||..| :|:...|.|.:        .||...|.|..|.|:.....:|..|
Human   342 R---SLSPKI-MQEAFLVQEVV--------ELPVTERQIEREHLIQLRRWQETRGELQCRSPPRL 394

  Fly   670 ----GMVDEEP 676
                .::|.||
Human   395 HGAKAILDAEP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	43/242 (18%)
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		12/37 (32%)
		TBC	117..320	CDD:214540	43/235 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..515		2/3 (67%)
		ZipA	<403..>502	CDD:331990	2/3 (67%)
		Binding to the PDZ domain of EBP50	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810