DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d15-17 and TBC1D17

DIOPT Version :9

Sequence 1:NP_001259806.1 Gene:Tbc1d15-17 / 33184 FlyBaseID:FBgn0031233 Length:715 Species:Drosophila melanogaster
Sequence 2:NP_078958.2 Gene:TBC1D17 / 79735 HGNCID:25699 Length:648 Species:Homo sapiens


Alignment Length:712 Identity:225/712 - (31%)
Similarity:324/712 - (45%) Gaps:123/712 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 QGTG-NILFTHDGVLLKKASAEHIADLNT--SGSLSLVEYSRSIAEMPRRRLLLEWQP----NDS 93
            :|.| .::|...||.| ..||:...|.::  :|.:.:||....:        ||.|.|    .||
Human     2 EGAGYRVVFEKGGVYL-HTSAKKYQDRDSLIAGVIRVVEKDNDV--------LLHWAPVEEAGDS 57

  Fly    94 IMIADDSQD-------------------QGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTR 139
            ..|....:|                   :.|||::..:..:.     |.:..||..|||  ....
Human    58 TQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQL-----CHSEPTRGAEPS--CPQG 115

  Fly   140 SRVMRAQLEDLSSVEVRHRGQTIRF--MRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETS 202
            |......|.:|.|:.....|.:..:  :...|.|......|..|.....:|.:....|:   .:|
Human   116 SWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLL---ASS 177

  Fly   203 RSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQR--SP 265
            .....:|.:...::..|..:|..|.:....:|.:                :..::|.|:..  |.
Human   178 PQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNV----------------VSRFLQDPYSTTFSS 226

  Fly   266 KSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAE-KSPADSE----LETLNAQDE 325
            .||......|..|..|:                      |.::: ..|.|.|    .|.::..: 
Human   227 FSRVTNFFRGALQPQPE----------------------GAASDLPPPPDDEPEPGFEVISCVE- 268

  Fly   326 KIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYL 390
                 |..|..||||.|:||.:|.....|:||:.....:|..||.||:..|||.|.|||||.|..
Human   269 -----LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328

  Fly   391 WSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEAN---FCGYRERKCQIEKDVKRTDRSLQFFA 452
            |..|..|.....::|:.||:.||.||.:::..||..   ..|||.   .||:||.||||:.:|:.
Human   329 WEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRS---LIERDVSRTDRTNKFYE 390

  Fly   453 GEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDID 517
            |.:||.|.||..||:||.||:|||||||||||||:|||.:..||||.||||.||||||..||:..
Human   391 GPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEES 455

  Fly   518 QAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRL 582
            |..||.|..::..|:...:..|.:::.|.||.::.|||||||:|:|||....|||:|||.|||.|
Human   456 QETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGL 520

  Fly   583 PCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLP 647
            |.||.|||.:.||||.|...::.|.:...|||||:|||:..:.|:..|..||.::.||.....||
Human   521 PGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELP 585

  Fly   648 NDIRSIIG-----EPLLPAAAGEEIDGGMVDEEPT---------YSDDGFDELVKELTPEEK 695
            ::::.|:|     ||..|:.....:........||         ..|...     |:.|||:
Human   586 HNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSL-----EILPEEE 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d15-17NP_001259806.1 DUF3548 37..>191 CDD:192931 39/181 (22%)
TBC 369..598 CDD:214540 120/231 (52%)
TBC1D17NP_078958.2 DUF3548 5..218 CDD:192931 45/247 (18%)
Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040 218..309 28/118 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..259 5/40 (13%)
TBC 307..542 CDD:214540 122/237 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..648 10/54 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2116
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2574
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1495285at2759
OrthoFinder 1 1.000 - - FOG0002107
OrthoInspector 1 1.000 - - otm41532
orthoMCL 1 0.900 - - OOG6_101355
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2140
SonicParanoid 1 1.000 - - X1395
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.760

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