Protein Alignment Tbc1d15-17 and TBC1D17

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_078958.2
• Gene: TBC1D17 / 79735
• HGNCID: 25699
• Length: 648
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 225/712 - (31%)
• Similarity: 324/712 - (45%)
• Gaps: 123/712 - (17%)

  Fly    36 QGTG-NILFTHDGVLLKKASAEHIADLNT--SGSLSLVEYSRSIAEMPRRRLLLEWQP----NDS 93
            :|.| .::|...||.| ..||:...|.::  :|.:.:||....:        ||.|.|    .||
Human     2 EGAGYRVVFEKGGVYL-HTSAKKYQDRDSLIAGVIRVVEKDNDV--------LLHWAPVEEAGDS 57

  Fly    94 IMIADDSQD-------------------QGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTR 139
            ..|....:|                   :.|||::..:..:.     |.:..||..|||  ....
Human    58 TQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQL-----CHSEPTRGAEPS--CPQG 115

  Fly   140 SRVMRAQLEDLSSVEVRHRGQTIRF--MRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETS 202
            |......|.:|.|:.....|.:..:  :...|.|......|..|.....:|.:....|:   .:|
Human   116 SWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLL---ASS 177

  Fly   203 RSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQR--SP 265
            .....:|.:...::..|..:|..|.:....:|.:                :..::|.|:..  |.
Human   178 PQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNV----------------VSRFLQDPYSTTFSS 226

  Fly   266 KSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAE-KSPADSE----LETLNAQDE 325
            .||......|..|..|:                      |.::: ..|.|.|    .|.::..:
Human   227 FSRVTNFFRGALQPQPE----------------------GAASDLPPPPDDEPEPGFEVISCVE- 268

  Fly   326 KIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYL 390
                 |..|..||||.|:||.:|.....|:||:.....:|..||.||:..|||.|.|||||.|..
Human   269 -----LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328

  Fly   391 WSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEAN---FCGYRERKCQIEKDVKRTDRSLQFFA 452
            |..|..|.....::|:.||:.||.||.:::..||..   ..|||.   .||:||.||||:.:|:.
Human   329 WEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRS---LIERDVSRTDRTNKFYE 390

  Fly   453 GEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDID 517
            |.:||.|.||..||:||.||:|||||||||||||:|||.:..||||.||||.||||||..||:..
Human   391 GPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEES 455

  Fly   518 QAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRL 582
            |..||.|..::..|:...:..|.:::.|.||.::.|||||||:|:|||....|||:|||.|||.|
Human   456 QETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGL 520

  Fly   583 PCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLP 647
            |.||.|||.:.||||.|...::.|.:...|||||:|||:..:.|:..|..||.::.||.....||
Human   521 PGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELP 585

  Fly   648 NDIRSIIG-----EPLLPAAAGEEIDGGMVDEEPT---------YSDDGFDELVKELTPEEK 695
            ::::.|:|     ||..|:.....:........||         ..|...     |:.|||:
Human   586 HNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSL-----EILPEEE 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	120/231 (52%)
TBC1D17	NP_078958.2	PH_RBD	7..205	CDD:432305	43/216 (20%)
		Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040	218..309		28/118 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..259		5/40 (13%)
		TBC	307..542	CDD:214540	122/237 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..648		10/54 (19%)