DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d9b

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001277689.1	Gene:	Tbc1d9b / 76795	MGIID:	1924045	Length:	1263	Species:	Mus musculus

Alignment Length:	863	Identity:	155/863 - (17%)
Similarity:	281/863 - (32%)	Gaps:	271/863 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGVF-NESQLSS---------VEEDVQNLPQQGTGNILFTHDGVLLKKASAEHIADLNTSGSLSL 69
            |.:| ||..:::         :.|:.:||..||      ..|....|:|..:............|
Mouse    98 LSIFDNEEDITTFVKGKIHGIIAEENKNLQPQG------DEDPGKFKEAELKMRKQFGMPEGEKL 156

  Fly    70 VEYSRS---IAEMPRR---------------------RLLLEW------QPNDSIMIAD----DS 100
            |.|...   ...:||:                     .|:::|      :.|.:::..:    |:
Mouse   157 VNYYSCNFWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDVTRLEKNATLLFPESIRVDT 221

  Fly   101 QDQ----------GD-WALVDRISG-RTRTTSECRAF-----NTRPIEPSGGATTRSRVM--RAQ 146
            :||          |: :.|:::::. ..|...:...|     ..|||.|....:...|.:  ||:
Mouse   222 RDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHKNISALKRDLDARAK 286

  Fly   147 LEDLSSV-----EVRHRGQTIRFMRKGANGVH--SEFFFQHG---------NADLFVRSMRDQHL 195
            .|...:.     :.|..|.|...:....|.:|  .:.|..:.         :|...:..:|:..:
Mouse   287 NECYRATFRLPKDERLDGHTGCTLWTPFNKLHIPGQMFISNNYICFASKEEDACRLIIPLREVTI 351

  Fly   196 IENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPP 260
            :|.|::|.......:|.|    |.|.||.        .:.|....:|..:::..|
Mouse   352 VEKADSSSVLPSPLSIST----KSKMTFL--------FANLKDRDFLVQRISDFL---------- 394

  Fly   261 FQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADS-------ELE 318
             |::|..:.|..|.|.:.:..|        .:..|..:....|...::..||..|       |:.
Mouse   395 -QKTPSKQTGSSIGGTKASVSD--------PAPESLPTPQEASEPPASPSSPLSSPPSFSTQEIP 450

  Fly   319 TLNAQDEKIV-NNLPDRQRVERG--HPLTETQW----LEFQTPDGR---ISDSARIKELIFRGGV 373
            |.:....|:. .|.|......:|  ..:.|..|    .|:    ||   :..:|:.:||:.: |:
Mouse   451 TTSQGLLKVFQKNSPMEDLGAKGAKEKMKEESWNIHFFEY----GRGMCMYRTAKTRELVLK-GI 510

  Fly   374 VQSLRPEVWKFLLNYYLWSD--THVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQ 436
            .:|||.|:|  ||....|::  ||........:||:..|::..:                    :
Mouse   511 PESLRGELW--LLFSGAWNEMVTHPGYYAELVEKSLGKYSLATE--------------------E 553

  Fly   437 IEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFW 501
            ||:|:.|:......|..|  ..:..|:.:|..|...|..:||.|.| :::..:|.:..:|.:.||
Mouse   554 IERDLHRSMPEHPAFQNE--LGIAALRRVLTAYAFRNPTIGYCQAM-NIVTSVLLLYGSEEEAFW 615

  Fly   502 CFVGFMELVFTNFD--------IDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWL 558
            ..|...|.:..::.        :|| |:   |.::.|.:    .|..:...............|.
Mouse   616 LLVALCERMLPDYYNTRVVGALVDQ-GI---FEELTRDV----LPRLSEKMQELGVISSISLSWF 672

  Fly   559 LVWYKRELNSEDVLKLWECLW--------------------------------TRL--------- 582
            |..:...:..|..:.:.:|.:                                |.|
Mouse   673 LTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANVEQLLDCNDEGEAMTVLGRYLDNVVN 737

  Fly   583 ------PCPNFHLLFS--------VAILD---------QETRVIIDSQYEFTEILKHVNELSGNI 624
                  |.|:.|.|.:        |.|.|         ...|.....|..|.:.||.:..|....
Mouse   738 KQSISPPIPHLHALLTSGDDPPVEVDIFDLLRVSYEKFSNLRADDIEQMRFKQRLKVIQSLEDTA 802

  Fly   625 ----------DVQKTLQVAEGIYLQLKGSETLP-----NDIRSIIGEPLLPAAAGEEIDGGMVDE 674
                      |:..:::..|.:|:..|......     |...::..:|.||......||...
Mouse   803 KRSVVRAIPGDIGFSIEELEDLYMVFKAKHLASQYWGGNRSAAVHRDPSLPYLEQYRIDASQ--- 864

  Fly   675 EPTYSDDGFDELVKELTP 692
                    |.||...|||
Mouse   865 --------FRELFASLTP 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	34/222 (15%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/302 (18%)
Tbc1d9b	NP_001277689.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	13/97 (13%)
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	19/106 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..449		10/59 (17%)
		TBC	506..716	CDD:214540	44/243 (18%)
		EFh	<856..907	CDD:298682	8/30 (27%)
		EFh	887..912	CDD:197492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900